Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases von Tabassum, Rubina, Ripatti, Samuli

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Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease von Folkersen, Lasse, Fauman, Eric, Sabater-Lleal, Maria, Strawbridge, Rona J, Frånberg, Mattias, Sennblad, Bengt, Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E, Rauramaa, Rainer, de Faire, Ulf, Smit, Andries J, Giral, Philippe, Kurl, Sudhir, Mannarino, Elmo, Enroth, Stefan, Johansson, Åsa, Enroth, Sofia Bosdotter, Gustafsson, Stefan, Lind, Lars, Lindgren, Cecilia, Morris, Andrew P, Giedraitis, Vilmantas, Silveira, Angela, Franco-Cereceda, Anders, Tremoli, Elena, Gyllensten, Ulf, Ingelsson, Erik, Brunak, Søren, Eriksson, Per, Ziemek, Daniel, Hamsten, Anders, Mälarstig, Anders

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Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies von Benner, Christian, Havulinna, Aki S., Järvelin, Marjo-Riitta, Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

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FINEMAP: efficient variable selection using summary data from genome-wide association studies von Benner, Christian, Spencer, Chris C A, Havulinna, Aki S, Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

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Genetics of 35 blood and urine biomarkers in the UK Biobank von Sinnott-Armstrong, Nasa, Tanigawa, Yosuke, Amar, David, Mars, Nina, Benner, Christian, Aguirre, Matthew, Venkataraman, Guhan Ram, Wainberg, Michael, Ollila, Hanna M., Kiiskinen, Tuomo, Havulinna, Aki S., Pirruccello, James P., Qian, Junyang, Shcherbina, Anna, Rodriguez, Fatima, Assimes, Themistocles L., Agarwala, Vineeta, Tibshirani, Robert, Hastie, Trevor, Ripatti, Samuli, Pritchard, Jonathan K., Daly, Mark J., Rivas, Manuel A.

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Significant sparse polygenic risk scores across 813 traits in UK Biobank von Tanigawa, Yosuke, Qian, Junyang, Venkataraman, Guhan, Justesen, Johanne Marie, Li, Ruilin, Tibshirani, Robert, Hastie, Trevor, Rivas, Manuel A

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Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps von Adeyemo, Adebowale, Balaconis, Mary K., Darnes, Deanna R., Fatumo, Segun, Granados Moreno, Palmira, Hodonsky, Chani J., Inouye, Michael, Kanai, Masahiro, Kato, Kazuto, Knoppers, Bartha M., Lewis, Anna C. F., Martin, Alicia R., McCarthy, Mark I., Meyer, Michelle N., Okada, Yukinori, Richards, J. Brent, Richter, Lucas, Ripatti, Samuli, Rotimi, Charles N., Sanderson, Saskia C., Sturm, Amy C., Verdugo, Ricardo A., Widen, Elisabeth, Willer, Cristen J., Wojcik, Genevieve L., Zhou, Alicia

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Systematic comparison of family history and polygenic risk across 24 common diseases von Mars, Nina, Lindbohm, Joni V., della Briotta Parolo, Pietro, Widén, Elisabeth, Kaprio, Jaakko, Palotie, Aarno, Ripatti, Samuli

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Regularized machine learning in the genetic prediction of complex traits von Okser, Sebastian, Pahikkala, Tapio, Airola, Antti, Salakoski, Tapio, Ripatti, Samuli, Aittokallio, Tero

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Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization von Millard, Louise A C, Davies, Neil M, Tilling, Kate, Gaunt, Tom R, Davey Smith, George

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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors von Ahola-Olli, Ari V., Würtz, Peter, Havulinna, Aki S., Aalto, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarne, Perola, Markus, Viikari, Jorma S., Jalkanen, Sirpa, Maksimow, Mikael, Salomaa, Veikko, Salmi, Marko, Kettunen, Johannes, Raitakari, Olli T.

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Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent von Buchwald, Jadwiga, Chenoweth, Meghan J., Palviainen, Teemu, Zhu, Gu, Benner, Christian, Gordon, Scott, Korhonen, Tellervo, Ripatti, Samuli, Madden, Pamela A. F., Lehtimäki, Terho, Raitakari, Olli T., Salomaa, Veikko, Rose, Richard J., George, Tony P., Lerman, Caryn, Pirinen, Matti, Martin, Nicholas G., Kaprio, Jaakko, Loukola, Anu, Tyndale, Rachel F.

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Genomic prediction of coronary heart disease von Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

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Genetic Risk Prediction and a 2-Stage Risk Screening Strategy for Coronary Heart Disease von Tikkanen, Emmi, Havulinna, Aki S., Palotie, Aarno, Salomaa, Veikko, Ripatti, Samuli

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Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data von Shi, Jianxin, Park, Ju-Hyun, Duan, Jubao, Berndt, Sonja T, Moy, Winton, Yu, Kai, Song, Lei, Wheeler, William, Hua, Xing, Silverman, Debra, Garcia-Closas, Montserrat, Hsiung, Chao Agnes, Figueroa, Jonine D, Cortessis, Victoria K, Malats, Núria, Karagas, Margaret R, Vineis, Paolo, Chang, I-Shou, Lin, Dongxin, Zhou, Baosen, Seow, Adeline, Matsuo, Keitaro, Hong, Yun-Chul, Caporaso, Neil E, Wolpin, Brian, Jacobs, Eric, Petersen, Gloria M, Klein, Alison P, Li, Donghui, Risch, Harvey, Sanders, Alan R, Hsu, Li, Schoen, Robert E, Brenner, Hermann, Stolzenberg-Solomon, Rachael, Gejman, Pablo, Lan, Qing, Rothman, Nathaniel, Amundadottir, Laufey T, Landi, Maria Teresa, Levinson, Douglas F, Chanock, Stephen J, Chatterjee, Nilanjan

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The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease von Moutsianas, Loukas, Agarwala, Vineeta, Fuchsberger, Christian, Flannick, Jason, Rivas, Manuel A, Gaulton, Kyle J, Albers, Patrick K, McVean, Gil, Boehnke, Michael, Altshuler, David, McCarthy, Mark I

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Genome-wide association analysis of plasma lipidome identifies 495 genetic associations von Ottensmann, Linda, Tabassum, Rubina, Ruotsalainen, Sanni E., Gerl, Mathias J., Klose, Christian, Widén, Elisabeth, Simons, Kai, Ripatti, Samuli, Pirinen, Matti

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Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland von Kerminen, Sini, Martin, Alicia R., Koskela, Jukka, Ruotsalainen, Sanni E., Havulinna, Aki S., Surakka, Ida, Palotie, Aarno, Perola, Markus, Salomaa, Veikko, Daly, Mark J., Ripatti, Samuli, Pirinen, Matti

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Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel von Mitt, Mario, Kals, Mart, Pärn, Kalle, Gabriel, Stacey B, Lander, Eric S, Palotie, Aarno, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit

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Clinical Prediction Model and Tool for Assessing Risk of Persistent Pain After Breast Cancer Surgery von Meretoja, Tuomo J, Andersen, Kenneth Geving, Bruce, Julie, Haasio, Lassi, Sipilä, Reetta, Scott, Neil W, Ripatti, Samuli, Kehlet, Henrik, Kalso, Eija

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