Role of glia in optic nerve von Yazdankhah, Meysam, Shang, Peng, Ghosh, Sayan, Hose, Stacey, Liu, Haitao, Weiss, Joseph, Fitting, Christopher S., Bhutto, Imran A., Zigler, J. Samuel, Qian, Jiang, Sahel, José-Alain, Sinha, Debasish, Stepicheva, Nadezda A.

Volltext

The role of lipocalin-2 in age-related macular degeneration (AMD) von Ghosh, Sayan, Stepicheva, Nadezda, Yazdankhah, Meysam, Shang, Peng, Watson, Alan M., Hose, Stacey, Liu, Haitao, Weiss, Joseph, Zigler, J. Samuel, Valapala, Mallika, Watkins, Simon C., Sinha, Debasish

Volltext

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium von Sinha, Debasish, Valapala, Mallika, Shang, Peng, Hose, Stacey, Grebe, Rhonda, Lutty, Gerard A., Zigler, J. Samuel, Kaarniranta, Kai, Handa, James T.

Volltext

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy von Liu, Haitao, Stepicheva, Nadezda A., Ghosh, Sayan, Shang, Peng, Chowdhury, Olivia, Daley, Rachel A., Yazdankhah, Meysam, Gupta, Urvi, Hose, Stacey L., Valapala, Mallika, Fitting, Christopher Scott, Strizhakova, Anastasia, Shan, Yang, Feenstra, Derrick, Sahel, José-Alain, Jayagopal, Ashwath, Handa, James T., Zigler, J. Samuel, Fort, Patrice E., Sodhi, Akrit, Sinha, Debasish

Volltext

Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy von Liu, Haitao, Ghosh, Sayan, Vaidya, Tanuja, Bammidi, Sridhar, Huang, Chao, Shang, Peng, Nair, Archana Padmanabhan, Chowdhury, Olivia, Stepicheva, Nadezda A, Strizhakova, Anastasia, Hose, Stacey, Mitrousis, Nikolaos, Gadde, Santosh Gopikrishna, Mb, Thirumalesh, Strassburger, Pamela, Widmer, Gabriella, Lad, Eleonora M, Fort, Patrice E, Sahel, José-Alain, Zigler, Jr, J Samuel, Sethu, Swaminathan, Westenskow, Peter D, Proia, Alan D, Sodhi, Akrit, Ghosh, Arkasubhra, Feenstra, Derrick, Sinha, Debasish

Volltext

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD von Gupta, Urvi, Ghosh, Sayan, Wallace, Callen T., Shang, Peng, Xin, Ying, Nair, Archana Padmanabhan, Yazdankhah, Meysam, Strizhakova, Anastasia, Ross, Mark A., Liu, Haitao, Hose, Stacey, Stepicheva, Nadezda A., Chowdhury, Olivia, Nemani, Mihir, Maddipatla, Vishnu, Grebe, Rhonda, Das, Manjula, Lathrop, Kira L., Sahel, José-Alain, Zigler, J. Samuel, Qian, Jiang, Ghosh, Arkasubhra, Sergeev, Yuri, Handa, James T., St. Croix, Claudette M., Sinha, Debasish

Volltext

Primary Cell Cultures from the Mouse Retinal Pigment Epithelium von Shang, Peng, Stepicheva, Nadezda A, Hose, Stacey, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration von Ghosh, Sayan, Shang, Peng, Terasaki, Hiroto, Stepicheva, Nadezda, Hose, Stacey, Yazdankhah, Meysam, Weiss, Joseph, Sakamoto, Taiji, Bhutto, Imran A, Xia, Shuli, Zigler, Jr, J Samuel, Kannan, Ram, Qian, Jiang, Handa, James T, Sinha, Debasish

Volltext

BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes von Yazdankhah, Meysam, Ghosh, Sayan, Shang, Peng, Stepicheva, Nadezda, Hose, Stacey, Liu, Haitao, Chamling, Xitiz, Tian, Shenghe, Sullivan, Mara L.G., Calderon, Michael Joseph, Fitting, Christopher S., Weiss, Joseph, Jayagopal, Ashwath, Handa, James T., Sahel, José-Alain, Zigler, J. Samuel, Kinchington, Paul R., Zack, Donald J., Sinha, Debasish

Volltext

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat von Zigler, J. Samuel Jr, Zhang, Cheng, Grebe, Rhonda, Sehrawat, Gitanjali, Hackler, Laszlo Jr, Adhya, Souvonik, Hose, Stacey, McLeod, D. Scott, Bhutto, Imran, Barbour, Walid, Parthasarathy, Geetha, Zack, Donald J, Sergeev, Yuri, Lutty, Gerard A, Handa, James T, Sinha, Debasish

Volltext

βA3/A1-crystallin: More than a lens protein von Zigler, J. Samuel, Sinha, Debasish

Volltext

A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems von Zigler, Jr, J Samuel, Hodgkinson, Colin A, Wright, Megan, Klise, Andrew, Sundin, Olof, Broman, Karl W, Hejtmancik, Fielding, Huang, Hao, Patek, Bonnie, Sergeev, Yuri, Hose, Stacey, Brayton, Cory, Xaiodong, Jiao, Vasquez, David, Maragakis, Nicholas, Mori, Susumu, Goldman, David, Hoke, Ahmet, Sinha, Debasish

Volltext

A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD von Shang, Peng, Stepicheva, Nadezda A., Liu, Haitao, Chowdhury, Olivia, Franks, Jonathan, Sun, Ming, Hose, Stacey, Ghosh, Sayan, Yazdankhah, Meysam, Strizhakova, Anastasia, Stolz, Donna Beer, Zigler, J. Samuel, Sinha, Debasish

Volltext

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells von Shang, Peng, Stepicheva, Nadezda, Teel, Kenneth, McCauley, Austin, Fitting, Christopher Scott, Hose, Stacey, Grebe, Rhonda, Yazdankhah, Meysam, Ghosh, Sayan, Liu, Haitao, Strizhakova, Anastasia, Weiss, Joseph, Bhutto, Imran A., Lutty, Gerard A., Jayagopal, Ashwath, Qian, Jiang, Sahel, José-Alain, Samuel Zigler, J., Handa, James T., Sergeev, Yuri, Rajala, Raju V. S., Watkins, Simon, Sinha, Debasish

Volltext

Mitophagy in Astrocytes Is Required for the Health of Optic Nerve von Yazdankhah, Meysam, Ghosh, Sayan, Liu, Haitao, Hose, Stacey, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext

Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy von Daley, Rachel, Maddipatla, Vishnu, Ghosh, Sayan, Chowdhury, Olivia, Hose, Stacey, Zigler, J. Samuel, Sinha, Debasish, Liu, Haitao

Volltext

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling von Shang, Peng, Valapala, Mallika, Grebe, Rhonda, Hose, Stacey, Ghosh, Sayan, Bhutto, Imran A., Handa, James T., Lutty, Gerard A., Lu, Lixia, Wan, Jun, Qian, Jiang, Sergeev, Yuri, Puertollano, Rosa, Zigler, J. Samuel, Xu, Guo‐Tong, Sinha, Debasish

Volltext

Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes von Valapala, Mallika, Hose, Stacey, Gongora, Celine, Dong, Lijin, Wawrousek, Eric F., Samuel Zigler, J., Sinha, Debasish

Volltext

Activating the AKT2–nuclear factor‐κB–lipocalin‐2 axis elicits an inflammatory response in age‐related macular degeneration von Ghosh, Sayan, Shang, Peng, Yazdankhah, Meysam, Bhutto, Imran, Hose, Stacey, Montezuma, Sandra R, Luo, Tianqi, Chattopadhyay, Sreya, Qian, Jiang, Lutty, Gerard A, Ferrington, Deborah A, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling von Valapala, Mallika, Wilson, Christine, Hose, Stacey, Bhutto, Imran A, Grebe, Rhonda, Dong, Aling, Greenbaum, Seth, Gu, Limin, Sengupta, Samhita, Cano, Marisol, Hackett, Sean, Xu, Guotong, Lutty, Gerard A, Dong, Lijin, Sergeev, Yuri, Handa, James T, Campochiaro, Peter, Wawrousek, Eric, Zigler, Jr, J Samuel, Sinha, Debasish

Volltext