The Implications of Clonal Genome Evolution for Cancer Medicine von Aparicio, Samuel, Caldas, Carlos

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Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene von d'Anglemont de Tassigny, Xavier, Fagg, Lisa A, Dixon, John P.C, Day, Kate, Leitch, Harry G, Hendrick, Alan G, Zahn, Dirk, Franceschini, Isabelle, Caraty, Alain, Carlton, Mark B.L, Aparicio, Samuel A.J.R, Colledge, William H

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation von Yap, Damian B., Chu, Justin, Berg, Tobias, Schapira, Matthieu, Cheng, S.-W. Grace, Moradian, Annie, Morin, Ryan D., Mungall, Andrew J., Meissner, Barbara, Boyle, Merrill, Marquez, Victor E., Marra, Marco A., Gascoyne, Randy D., Humphries, R. Keith, Arrowsmith, Cheryl H., Morin, Gregg B., Aparicio, Samuel A.J.R.

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Genome-driven integrated classification of breast cancer validated in over 7,500 samples von Ali, H Raza, Rueda, Oscar M, Chin, Suet-Feung, Curtis, Christina, Dunning, Mark J, Aparicio, Samuel Ajr, Caldas, Carlos

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Examining the utility of patient-derived xenograft mouse models von Aparicio, Samuel, Hidalgo, Manuel, Kung, Andrew L.

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The Life History of 21 Breast Cancers von Nik-Zainal, Serena, Van Loo, Peter, Wedge, David C., Alexandrov, Ludmil B., Greenman, Christopher D., Lau, King Wai, Raine, Keiran, Jones, David, Marshall, John, Ramakrishna, Manasa, Shlien, Adam, Cooke, Susanna L., Hinton, Jonathan, Menzies, Andrew, Stebbings, Lucy A., Leroy, Catherine, Jia, Mingming, Rance, Richard, Mudie, Laura J., Gamble, Stephen J., Stephens, Philip J., McLaren, Stuart, Tarpey, Patrick S., Papaemmanuil, Elli, Davies, Helen R., Varela, Ignacio, McBride, David J., Bignell, Graham R., Leung, Kenric, Butler, Adam P., Teague, Jon W., Martin, Sancha, Jönsson, Goran, Mariani, Odette, Boyault, Sandrine, Miron, Penelope, Fatima, Aquila, Langerød, Anita, Aparicio, Samuel A.J.R., Tutt, Andrew, Sieuwerts, Anieta M., Borg, Åke, Thomas, Gilles, Salomon, Anne Vincent, Richardson, Andrea L., Børresen-Dale, Anne-Lise, Futreal, P. Andrew, Stratton, Michael R., Campbell, Peter J.

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DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation von Batra, Rajbir Nath, Lifshitz, Aviezer, Vidakovic, Ana Tufegdzic, Chin, Suet-Feung, Sati-Batra, Ankita, Sammut, Stephen-John, Provenzano, Elena, Ali, H. Raza, Dariush, Ali, Bruna, Alejandra, Murphy, Leigh, Purushotham, Arnie, Ellis, Ian, Green, Andrew, Garrett-Bakelman, Francine E., Mason, Chris, Melnick, Ari, Aparicio, Samuel A. J. R., Rueda, Oscar M., Tanay, Amos, Caldas, Carlos

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Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups von Rueda, Oscar M., Sammut, Stephen-John, Seoane, Jose A., Chin, Suet-Feung, Caswell-Jin, Jennifer L., Callari, Maurizio, Batra, Rajbir, Pereira, Bernard, Bruna, Alejandra, Ali, H. Raza, Provenzano, Elena, Liu, Bin, Parisien, Michelle, Gillett, Cheryl, McKinney, Steven, Green, Andrew R., Murphy, Leigh, Purushotham, Arnie, Ellis, Ian O., Pharoah, Paul D., Rueda, Cristina, Aparicio, Samuel, Caldas, Carlos, Curtis, Christina

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Kisspeptin Directly Stimulates Gonadotropin-Releasing Hormone Release via G Protein-Coupled Receptor 54 von Messager, Sophie, Chatzidaki, Emmanouella E., Ma, Dan, Hendrick, Alan G., Zahn, Dirk, Dixon, John, Thresher, Rosemary R., Malinge, Isabelle, Lomet, Didier, Mark B. L. Carlton, Colledge, William H., Caraty, Alain, Samuel A. J. R. Aparicio, Brenner, Sydney

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Mutational Processes Molding the Genomes of 21 Breast Cancers von Nik-Zainal, Serena, Alexandrov, Ludmil B., Wedge, David C., Van Loo, Peter, Greenman, Christopher D., Raine, Keiran, Jones, David, Hinton, Jonathan, Marshall, John, Stebbings, Lucy A., Menzies, Andrew, Martin, Sancha, Leung, Kenric, Chen, Lina, Leroy, Catherine, Ramakrishna, Manasa, Rance, Richard, Lau, King Wai, Mudie, Laura J., Varela, Ignacio, McBride, David J., Bignell, Graham R., Cooke, Susanna L., Shlien, Adam, Gamble, John, Whitmore, Ian, Maddison, Mark, Tarpey, Patrick S., Davies, Helen R., Papaemmanuil, Elli, Stephens, Philip J., McLaren, Stuart, Butler, Adam P., Teague, Jon W., Jönsson, Göran, Garber, Judy E., Silver, Daniel, Miron, Penelope, Fatima, Aquila, Boyault, Sandrine, Langerød, Anita, Tutt, Andrew, Martens, John W.M., Aparicio, Samuel A.J.R., Borg, Åke, Salomon, Anne Vincent, Thomas, Gilles, Børresen-Dale, Anne-Lise, Richardson, Andrea L., Neuberger, Michael S., Futreal, P. Andrew, Campbell, Peter J., Stratton, Michael R.

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PyClone: statistical inference of clonal population structure in cancer von Roth, Andrew, Khattra, Jaswinder, Yap, Damian, Wan, Adrian, Laks, Emma, Biele, Justina, Ha, Gavin, Aparicio, Samuel, Bouchard-Côté, Alexandre, Shah, Sohrab P

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loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis von Vessey, John P, Macchi, Paolo, Stein, Joel M, Mikl, Martin, Hawker, Kelvin N, Vogelsang, Petra, Wieczorek, Krzysztof, Vendra, Georgia, Riefler, Julia, Tübing, Fabian, Aparicio, Samuel A.J, Abel, Ted, Kiebler, Michael A

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Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling von Zhang, Allen W., O’Flanagan, Ciara, Chavez, Elizabeth A., Lim, Jamie L. P., Ceglia, Nicholas, McPherson, Andrew, Wiens, Matt, Walters, Pascale, Chan, Tim, Hewitson, Brittany, Lai, Daniel, Mottok, Anja, Sarkozy, Clementine, Chong, Lauren, Aoki, Tomohiro, Wang, Xuehai, Weng, Andrew P, McAlpine, Jessica N., Aparicio, Samuel, Steidl, Christian, Campbell, Kieran R., Shah, Sohrab P.

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The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse von Waller-Evans, Helen, Prömel, Simone, Langenhan, Tobias, Dixon, John, Zahn, Dirk, Colledge, William H, Doran, Joanne, Carlton, Mark B L, Davies, Ben, Aparicio, Samuel A J R, Grosse, Johannes, Russ, Andreas P

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The GPR54 Gene as a Regulator of Puberty von Seminara, Stephanie B, Messager, Sophie, Chatzidaki, Emmanouella E, Thresher, Rosemary R, Acierno, James S, Shagoury, Jenna K, Bo-Abbas, Yousef, Kuohung, Wendy, Schwinof, Kristine M, Hendrick, Alan G, Zahn, Dirk, Dixon, John, Kaiser, Ursula B, Slaugenhaupt, Susan A, Gusella, James F, O'Rahilly, Stephen, Carlton, Mark B.L, Crowley, William F, Aparicio, Samuel A.J.R, Colledge, William H

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Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses von O'Flanagan, Ciara H, Campbell, Kieran R, Zhang, Allen W, Kabeer, Farhia, Lim, Jamie L P, Biele, Justina, Eirew, Peter, Lai, Daniel, McPherson, Andrew, Kong, Esther, Bates, Cherie, Borkowski, Kelly, Wiens, Matt, Hewitson, Brittany, Hopkins, James, Pham, Jenifer, Ceglia, Nicholas, Moore, Richard, Mungall, Andrew J, McAlpine, Jessica N, Shah, Sohrab P, Aparicio, Samuel

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Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution von Eirew, Peter, Steif, Adi, Khattra, Jaswinder, Ha, Gavin, Yap, Damian, Farahani, Hossein, Gelmon, Karen, Chia, Stephen, Mar, Colin, Wan, Adrian, Laks, Emma, Biele, Justina, Shumansky, Karey, Rosner, Jamie, McPherson, Andrew, Nielsen, Cydney, Roth, Andrew J. L., Lefebvre, Calvin, Bashashati, Ali, de Souza, Camila, Siu, Celia, Aniba, Radhouane, Brimhall, Jazmine, Oloumi, Arusha, Osako, Tomo, Bruna, Alejandra, Sandoval, Jose L., Algara, Teresa, Greenwood, Wendy, Leung, Kaston, Cheng, Hongwei, Xue, Hui, Wang, Yuzhuo, Lin, Dong, Mungall, Andrew J., Moore, Richard, Zhao, Yongjun, Lorette, Julie, Nguyen, Long, Huntsman, David, Eaves, Connie J., Hansen, Carl, Marra, Marco A., Caldas, Carlos, Shah, Sohrab P., Aparicio, Samuel

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Multi-Omic Analysis of CIC's Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity von Takemon, Yuka, LeBlanc, Véronique G, Song, Jungeun, Chan, Susanna Y, Lee, Stephen Dongsoo, Trinh, Diane L, Ahmad, Shiekh Tanveer, Brothers, William R, Corbett, Richard D, Gagliardi, Alessia, Moradian, Annie, Cairncross, J Gregory, Yip, Stephen, Aparicio, Samuel A J R, Chan, Jennifer A, Hughes, Christopher S, Morin, Gregg B, Gorski, Sharon M, Chittaranjan, Suganthi, Marra, Marco A

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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours von Xu, Hong, Di Antonio, Marco, McKinney, Steven, Mathew, Veena, Ho, Brandon, O’Neil, Nigel J., Santos, Nancy Dos, Silvester, Jennifer, Wei, Vivien, Garcia, Jessica, Kabeer, Farhia, Lai, Daniel, Soriano, Priscilla, Banáth, Judit, Chiu, Derek S., Yap, Damian, Le, Daniel D., Ye, Frank B., Zhang, Anni, Thu, Kelsie, Soong, John, Lin, Shu-chuan, Tsai, Angela Hsin Chin, Osako, Tomo, Algara, Teresa, Saunders, Darren N., Wong, Jason, Xian, Jian, Bally, Marcel B., Brenton, James D., Brown, Grant W., Shah, Sohrab P., Cescon, David, Mak, Tak W., Caldas, Carlos, Stirling, Peter C., Hieter, Phil, Balasubramanian, Shankar, Aparicio, Samuel

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High-throughput microfluidic single-cell RT-qPCR von White, Adam K, VanInsberghe, Michael, Petriv, Oleh I, Hamidi, Mani, Sikorski, Darek, Marra, Marco A, Piret, James, Aparicio, Samuel, Hansen, Carl L

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