MTH1 as a Chemotherapeutic Target: The Elephant in the Room von Samaranayake, Govindi J, Huynh, Mai, Rai, Priyamvada

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Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer von Samaranayake, Govindi J., Troccoli, Clara I., Huynh, Mai, Lyles, Rolando D. Z., Kage, Karen, Win, Andrew, Lakshmanan, Vishalakshi, Kwon, Deukwoo, Ban, Yuguang, Chen, Steven Xi, Zarco, Enrique Rodriguez, Jorda, Merce, Burnstein, Kerry L., Rai, Priyamvada

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OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1 von Zhang, Ling, Misiara, Laura, Samaranayake, Govindi J., Sharma, Nisha, Nguyen, Dao M., Tahara, Yu-Ki, Kool, Eric T., Rai, Priyamvada

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The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors von Samaranayake, Govindi J, Troccoli, Clara I, Zhang, Ling, Huynh, Mai, Jayaraj, Christina J, Ji, Debin, McPherson, Lisa, Onishi, Yoshiyuki, Nguyen, Dao M, Robbins, David J, Karbaschi, Mahsa, Cooke, Marcus S, Barrientos, Antonio, Kool, Eric T, Rai, Priyamvada

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Comparison of choroidal and retinal endothelial cells: Characteristics and response to VEGF isoforms and anti-VEGF treatments von Stewart, Elizabeth A., Samaranayake, Govindi J., Browning, Andrew C., Hopkinson, Andrew, Amoaku, Winfried M.

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Comparative gene expression profiling of human umbilical vein endothelial cells and ocular vascular endothelial cells von Browning, Andrew C, Halligan, Eugene P, Stewart, Elizabeth A, Swan, Daniel C, Dove, Rosamund, Samaranayake, Govindi J, Amoaku, Winfried M

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HGF and VEGF-A and Their Receptors Show Expression and Angiogenic Effects on Human Choroidal Endothelial Cells: Implications for Treatments of Neovascular Age-Related Macular Degen... von Stewart, Elizabeth A., Allen, Claire L., Samaranayake, Govindi J., Stubington, Thomas, Akhtar, Rukhsar, Branch, Matthew J., Amoaku, Winfried M.

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Abstract 2076: Low OGG1 protects against the DNA damage induced by MTH1 inhibition von Lincheta, Laura Misiara, Zhang, Ling, Samaranayake, Govindi, Sharma, Nisha, Nguyen, Dao, Tahara, Yu-Ki, Kool, Eric, Rai, Priyamvada

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Cellular 8-oxodGTPase activity as a novel target in KRAS-driven pancreatic cancer von Mateo-Victoriano, Beatriz, Zhang, Ling, Samaranayake, Govindi, Due, Cassie, Troccoli, Clara, Zaias, Julia, Nagathihalli, Nagaraj, Mohsen, Michael, Kool, Eric, Rai, Priyamvada

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Abstract 888: Exploring the signaling and activity interactome between oncogenic RAS and the nucleotide pool-detoxifying enzyme MTH1 von Samaranayake, Govindi J., Troccoli, Clara I., Jayaraj, Christina, Durden, Brittany C., Nagathihalli, Nagaraj, Merchant, Nipun, Rai, Priyamvada

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Abstract A38: MTH1 Inhibition as an effective tumor-suppressive strategy in RAS-driven cancer von Samaranayake, Govindi Jayanika, Troccoli, Clara Issabella, Cunningham, Tyler Andrew, Rai, Priyamvada

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The ROS duality in castration-resistant prostate cancer emergence and progression von Troccoli, Clara, Lyles, Rolando, Samaranayake, Govindi, Huynh, Mai, Kwon, Deukwoo, Ban, Yuguang, Chen, Steven, Jorda, Merce, Sharma, Nikita, Banerjee, Sulagna, Burnstein, Kerry, Rai, Priyamvada

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Abstract 5473: Towards a better understanding of MTH1 as a therapeutic target in RAS-driven cancer von Samaranayake, Govindi J., Troccoli, Clara I., Huynh, Mai Q., Win, Andrew, Ji, Debin, Kool, Eric T., Rai, Priyamvada

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Abstract B032: Inappropriate AR reactivation-induced redox stress as a novel therapeutic target in castration-resistant prostate cancer von Samaranayake, Govindi J., Troccoli, Clara I., Huynh, Mai Q., Lyles, Rolando D.Z., Kwon, Deukwoo, Ban, Yuguang, Chen, Steven Xi, Jorda, Merce, Burnstein, Kerry, Rai, Priyamvada

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145 - MTH1: A Novel Combatant of Oncogenic Oxidative Stress von Rai, Priyamvada, Samaranayake, Govindi Jaya, Soares, Renata Machado, de las Pozas, Alicia

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MTH1: A Novel Combatant of Oncogenic Oxidative Stress von Rai, Priyamvada, Samaranayake, Govindi Jaya, Soares, Renata Machado, de las Pozas, Alicia

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Abstract 5479: Redox stress as a therapeutic Achilles heel in castration-resistant prostate cancer von Troccoli, Clara I., Samaranayake, Govindi J., Huynh, Mai Q., Kage, Karen, Kwon, Deukwoo, Ban, Yuguang, Chen, Xi S., Zarco, Enrique R., Jorda, Merce, Burnstein, Kerry L., Rai, Priyamvada

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Abstract 4790: Oxidation in the nucleotide pool as a novel targetable vulnerability in pancreatic ductal adenocarcinoma von Mateo-Victoriano, Beatriz, Zhang, Ling, Samaranayake, Govindi J., Due, Cassie, Troccoli, Clara, Zaias, Julia, Nagathihalli, Nagaraj, VanSaun, Michael, Mohsen, Michael G., Kool, Eric T., Rai, Priyamvada

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Abstract B091: The mammalian 8-oxodGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma von Mateo-Victoriano, Beatriz, Zhang, Ling, Samaranayake, Govindi J., Mcgaughey, Vanessa, Due, Cassie, Troccoli, Clara, Mohsen, Michael G., Nagathihalli, Nagaraj S., McDonald, Oliver G., VanSaun, Michael, Kool, Eric T., Rai, Priyamvada

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