Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) von Germann, Ursula A, Furey, Brinley F, Markland, William, Hoover, Russell R, Aronov, Alex M, Roix, Jeffrey J, Hale, Michael, Boucher, Diane M, Sorrell, David A, Martinez-Botella, Gabriel, Fitzgibbon, Matthew, Shapiro, Paul, Wick, Michael J, Samadani, Ramin, Meshaw, Kathryn, Groover, Anna, DeCrescenzo, Gary, Namchuk, Mark, Emery, Caroline M, Saha, Saurabh, Welsch, Dean J

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Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity von Shah, Nirav G, Tulapurkar, Mohan E, Ramarathnam, Aparna, Brophy, Amanda, Martinez, 3rd, Ramon, Hom, Kellie, Hodges, Theresa, Samadani, Ramin, Singh, Ishwar S, MacKerell, Jr, Alexander D, Shapiro, Paul, Hasday, Jeffrey D

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Printing reflectance functions von Malzbender, Tom, Samadani, Ramin, Scher, Steven, Crume, Adam, Dunn, Douglas, Davis, James

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CD73 Inhibitor Oleclumab Plus Osimertinib in Previously Treated Patients With Advanced T790M-Negative EGFR-Mutated NSCLC: A Brief Report von Kim, Dong-Wan, Kim, Sang-We, Camidge, D. Ross, Shu, Catherine A., Marrone, Kristen A., Le, Xiuning, Blakely, Collin M., Park, Keunchil, Chang, Gee-Chen, Patel, Sandip Pravin, Kar, Gozde, Cooper, Zachary A., Samadani, Ramin, Pluta, Michael, Kumar, Rakesh, Ramalingam, Suresh

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Importance of Domain Closure for the Autoactivation of ERK2 von Barr, Daniel, Oashi, Taiji, Burkhard, Kimberly, Lucius, Sarah, Samadani, Ramin, Zhang, Jun, Shapiro, Paul, MacKerell, Alexander D, van der Vaart, Arjan

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No-Reference Blur Assessment of Digital Pictures Based on Multifeature Classifiers von Ciancio, A, da Costa, André Luiz N Targino, da Silva, Eduardo A B, Said, Amir, Samadani, Ramin, Obrador, Pere

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Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress von Martinez, Ramon, Huang, Weiliang, Samadani, Ramin, Mackowiak, Bryan, Centola, Garrick, Chen, Lijia, Conlon, Ivie L., Hom, Kellie, Kane, Maureen A., Fletcher, Steven, Shapiro, Paul

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Abstract CT163: CD73 inhibitor oleclumab plus osimertinib for advanced EGFRm NSCLC: First report of a Phase 1b/2 study von Kim, Dong-Wan, Kim, Sang-We, Camidge, D. Ross, Rizvi, Naiyer A., Marrone, Kristen A., Le, Xiuning, Blakely, Collin, Park, Keunchil, Chang, Gee-Chen, Patel, Sandip Pravin, Cooper, Zachary A., Kumar, Rakesh, Samadani, Ramin, McCombs, Rebecca, Pluta, Michael, Wu, Kevin Yufeng, Ramalingam, Suresh

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Exosomal Proteome Profiling: A Potential Multi-Marker Cellular Phenotyping Tool to Characterize Hypoxia-Induced Radiation Resistance in Breast Cancer von Thomas, Stefani N, Liao, Zhongping, Clark, David, Chen, Yangyi, Samadani, Ramin, Mao, Li, Ann, David K, Baulch, Janet E, Shapiro, Paul, Yang, Austin J

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Stereo Matching and View Interpolation Based on Image Domain Triangulation von Fickel, Guilherme Pinto, Jung, Claudio R., Malzbender, Tom, Samadani, Ramin, Culbertson, Bruce

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Distributed Image Coding for Digital Image Recovery From the Print-Scan Channel von Samadani, R., Mukherjee, D.

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Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf von Samadani, Ramin, Zhang, Jun, Brophy, Amanda, Oashi, Taiji, Priyakumar, U Deva, Raman, E Prabhu, St John, Franz J, Jung, Kwan-Young, Fletcher, Steven, Pozharski, Edwin, MacKerell, Jr, Alexander D, Shapiro, Paul

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Mechanistic Study of a Novel Thienyl Napthalenesulfonate Molecule that Selectively Inhibits Melanoma Cells with Constitutively‐Active ERK1/2 von Martinez, Ramon, Huang, Weiliang, Centola, Garrick, Samadani, Ramin, Chen, Lijia, Scheenstra, Jacob, Fletcher, Steven, Kane, Maureen, Mackerell, Alexander, Shapiro, Paul

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A finite mixtures algorithm for finding proportions in SAR images von Samadani, R.

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Abstract 3705: Overcoming drug resistance in BRaf mutated melanoma cells von Samadani, Ramin, Zhang, Jun, Mackerell, Alexander, Fletcher, Steven, Shapiro, Paul

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Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containin... von Jung, Kwan-Young, Samadani, Ramin, Chauhan, Jay, Nevels, Kerrick, Yap, Jeremy L, Zhang, Jun, Worlikar, Shilpa, Lanning, Maryanna E, Chen, Lijia, Ensey, Mary, Shukla, Sagar, Salmo, Rosene, Heinzl, Geoffrey, Gordon, Caryn, Dukes, Troy, MacKerell, Jr, Alexander D, Shapiro, Paul, Fletcher, Steven

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Abstract OT3-22-01: First-in-human global multi-center study of RLY-2608, a pan mutant and isoform selective PI3Kα inhibitor, as a single agent in advanced solid tumor patients and... von Varkaris, Andreas, Hamilton, Erika, Henry, Jason, Spira, Alexander I., Schram, Alison M., McGuinness, Julia E., Tan, Gege, Li, Xiaoyan, Hunter, Tamieka, Samadani, Ramin, Timm, Alison, Karanovic, Djuro, Subbiah, Vivek, Perez, Cesar A.

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Overcoming Drug‐Induced Resistance in BRaf Mutated Melanoma Cells von Samadani, Ramin, Jung, Kwan‐Young, Zhang, Jun, MacKerell, Alexander, Fletcher, Steven, Shapiro, Paul

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Abstract 4554: A docking domain directed inhibitor targeting ERK regulated F-site substrates von Zhang, Jun, Oashi, Taiji, Samadani, Ramin, Nevels, Kerrick, Burkhard, Kimberly, Priyakumar, Deva, Raman, Prabhu, Fletcher, Steven, Pozharsky, Edvin, Shapiro, Paul, MacKerell, Alexander

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Image Thumbnails That Represent Blur and Noise von Samadani, R., Mauer, T.A., Berfanger, D.M., Clark, J.H.

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