4- exo- dig and 5- exo- dig Cyclocarbopalladations: an expeditious solution toward molecular complexity? von Bour, Christophe, Blond, Gaëlle, Salem, Bahaâ, Suffert, Jean

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Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 von Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal

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A New Pd-Catalyzed Cascade Reaction for the Synthesis of Strained Aromatic Polycycles von Blond, Gaëlle, Bour, Christophe, Salem, Bahaâ, Suffert, Jean

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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors von Vulpetti, Anna, Randl, Stefan, Rüdisser, Simon, Ostermann, Nils, Erbel, Paul, Mac Sweeney, Aengus, Zoller, Thomas, Salem, Bahaa, Gerhartz, Bernd, Cumin, Frederic, Hommel, Ulrich, Dalvit, Claudio, Lorthiois, Edwige, Maibaum, Jürgen

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Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes von Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal

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A 4-exo-dig Cyclocarbopalladation/8π Electrocyclization Cascade: Expeditious Access to the Tricyclic Core Structures of the Ophiobolins and Aleurodiscal von Salem, Bahaâ, Suffert, Jean

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Comparison Between Fast-Track and Conventional Anesthesia for Children Undergoing Closure of Ventricular Septal Defects: A Systematic Review and Meta-Analysis von Nasif, Mohamad Nour, Alibrahim, Hidar, Hassan, Noheir Ashraf Ibrahem Fathy, Dashan, Sedra, Haj Saleh, Heba, Jabban, Yazan Khair Eldien, Soliman, Rami, Mohamed, Waleed Farouk, Gabr, Ihab Gebaly Mohammed, Osman, Ahmed Bahaa Salem Ali, Nader, Simon, AbuShady, Reham, Boktor, Ashraf N B, Nair, Nivedita, Alhanafy, Marwa Mohamed, Rashid, Asrar

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A 4-exo-dig cyclocarbopalladation/8pi electrocyclization cascade: expeditious access to the tricyclic core structures of the ophiobolins and aleurodiscal von Salem, Bahaâ, Suffert, Jean

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Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence von Furet, Pascal, Salem, Bahaa, Mesrouze, Yannick, Schmelzle, Tobias, Lewis, Ian, Kallen, Joerg, Chène, Patrick

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Cyclocarbopalladation:  5-Exo-dig Cyclization versus Direct Stille Cross-Coupling Reaction. The Influence of the α,β-Propargylic Substitution von Salem, Bahaâ, Delort, Estelle, Klotz, Philippe, Suffert, Jean

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Cyclocarbopalladation:  Formation of Bicyclic 1,2-Cyclobutanediols through a Rare 4-exo-dig Cyclization von Salem, Bahaâ, Klotz, Philippe, Suffert, Jean

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The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition von Furet, Pascal, Bordas, Vincent, Le Douget, Mickaël, Salem, Bahaa, Mesrouze, Yannick, Imbach‐Weese, Patricia, Sellner, Holger, Voegtle, Markus, Soldermann, Nicolas, Chapeau, Emilie, Wartmann, Markus, Scheufler, Clemens, Fernandez, Cesar, Kallen, Joerg, Guagnano, Vito, Chène, Patrick, Schmelzle, Tobias

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Small-molecule WNK inhibition regulates cardiovascular and renal function von Yamada, Ken, Park, Hyi-Man, Rigel, Dean F, DiPetrillo, Keith, Whalen, Erin J, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara Emily, Burdick, Debra A, Caplan, Shari L, Capparelli, Michael P, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waan-Jeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar K, Kohls, Darcy, Kunjathoor, Vidya, LaSala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal J, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka H, Trakshel, Gary M, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer B, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko I, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji-Hu, Zheng, Gang, Monovich, Lauren

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Cascade Cyclization via a 4-exo-dig-Cyclocarbopalladation for an Easy Access to New Polycyclic Structures von Salem, Bahaâ, Klotz, Philippe, Suffert, Jean

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Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022) von Furet, Pascal, Bordas, Vincent, Le Douget, Mickaël, Salem, Bahaa, Mesrouze, Yannick, Imbach‐Weese, Patricia, Sellner, Holger, Voegtle, Markus, Soldermann, Nicolas, Chapeau, Emilie, Wartmann, Markus, Scheufler, Clemens, Fernandez, Cesar, Kallen, Joerg, Guagnano, Vito, Chène, Patrick, Schmelzle, Tobias

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Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors von Sellner, Holger, Chapeau, Emilie, Furet, Pascal, Voegtle, Markus, Salem, Bahaa, Le Douget, Mickaël, Bordas, Vincent, Groell, Jean‐Marc, Le Goff, Anne‐Laure, Rouzet, Christine, Wietlisbach, Thomas, Zimmermann, Thomas, McKenna, Joseph, Brocklehurst, Cara E., Chène, Patrick, Wartmann, Markus, Scheufler, Clemens, Kallen, Joerg, Williams, Gareth, Harlfinger, Stephanie, Traebert, Martin, Dumotier, Bérengère M., Schmelzle, Tobias, Soldermann, Nicolas

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A 4-exo-dig Cyclocarbopalladation/8π Electrocyclization Cascade: Expeditious Access to the Tricyclic Core Structures of the Ophiobolins and Aleurodiscal von Salem, Bahaâ, Suffert, Jean

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Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019) von Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal

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ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myel... von Wylie, Andrew, Schoepfer, Joseph, Berellini, Giuliano, Cai, Hongbo, Caravatti, Giorgio, Cotesta, Simona, Dodd, Stephanie, Donovan, Jerry, Erb, Bernhard, Furet, Pascal, Gangal, Geeti, Grotzfeld, Robert, Hassan, Quamrul, Hood, Tami, Iyer, Varsha, Jacob, Sandra, Jahnke, Wolfgang, Lombardo, Franco, Loo, Alice, Manley, Paul W., Marzinzik, Andreas, Palmer, Michael, Pelle, Xavier, Salem, Bahaa, Sharma, Sreenath, Thohan, Sanjeev, Zhu, Suzanne, Keen, Nicholas, Petruzzelli, Lilli, Vanasse, K. Gary, Sellers, William R

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Cascade Cyclization:  Carbopalladative Cyclization Followed by Electrocyclic Closure as a Route to Complex Polycycles von Suffert, Jean, Salem, Bahâa, Klotz, Philippe

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