Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity von Miao, Xiusheng, Dear, Gordon J., Beaumont, Claire, Vitulli, Giovanni, Collins, Gary, Gorycki, Peter D., Harrell, Andrew W., Sakatis, Melanie Z.

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Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury von Schofield, Christopher A, Walker, Tracy M, Taylor, Maxine A, Patel, Metul, Vlachou, Denise F, Macina, Justyna M, Vidgeon-Hart, Martin P, Williams, Ann, McGill, Paul J, Newman, Carla F, Sakatis, Melanie Z

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Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds von Ogese, Monday O, Watkinson, Joel, Lister, Adam, Faulkner, Lee, Gibson, Andrew, Hillegas, Aimee, Sakatis, Melanie Z, Park, Brian Kevin, Naisbitt, Dean J

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A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment von Ogese, Monday O, Lister, Adam, Farrell, Liam, Gardner, Joshua, Kafu, Laila, Ali, Serat-E, Gibson, Andrew, Hillegas, Aimee, Meng, Xiaoli, Pirmohamed, Munir, Williams, Geoffrey S, Sakatis, Melanie Z, Naisbitt, Dean J

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Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds von Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E

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Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development von Tomlinson, Lindsay, Ramsden, Diane, Leite, Sofia Batista, Beken, Sonja, Bonzo, Jessica A., Brown, Paul, Candarlioglu, Pelin L., Chan, Tom S., Chen, Eugene, Choi, Colin K., David, Rhiannon, Delrue, Nathalie, Devine, Patrick J., Ford, Kevin, Garcia, Martha Iveth, Gosset, James R., Hewitt, Philip, Homan, Kimberly, Irrechukwu, Onyi, Kopec, Anna K., Liras, Jennifer L., Mandlekar, Sandhya, Raczynski, Arek, Sadrieh, Nakissa, Sakatis, Melanie Z., Siegel, Jeffrey, Sung, Kyung, Sunyovszki, Ilona, Van Vleet, Terry R., Ekert, Jason E., Hardwick, Rhiannon N.

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The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors von Sparey, Tim, Abeywickrema, Pravien, Almond, Sarah, Brandon, Nick, Byrne, Noel, Campbell, Alister, Hutson, Pete H., Jacobson, Marlene, Jones, Brian, Munshi, Sanjeev, Pascarella, Danette, Pike, Andrew, Prasad, G. Sridhar, Sachs, Nancy, Sakatis, Melanie, Sardana, Vinod, Venkatraman, Shankar, Young, Mary Beth

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An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development von Reese, Melinda, Sakatis, Melanie, Ambroso, Jeffrey, Harrell, Andrew, Yang, Eric, Chen, Liangfu, Taylor, Maxine, Baines, Ian, Zhu, Lei, Ayrton, Andy, Clarke, Stephen

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A quantitative high-throughput trapping assay as a measurement of potential for bioactivation von Meneses-Lorente, Georgina, Sakatis, Melanie Zea, Schulz-Utermoehl, Timothy, Nardi, Claudio De, Watt, Alan P.

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3D human tissue models and microphysiological systems for HIV and related comorbidities von Yin, Dwight E., Palin, Amy C., Lombo, Tania B., Mahon, Robert N., Poon, Betty, Wu, Da-Yu, Atala, Anthony, Brooks, Kristina M., Chen, Shuibing, Coyne, Carolyn B., D’Souza, M. Patricia, Fackler, Oliver T., Furler O’Brien, Robert L., Garcia-de-Alba, Carolina, Jean-Philippe, Patrick, Karn, Jonathan, Majji, Sai, Muotri, Alysson R., Ozulumba, Tochukwu, Sakatis, Melanie Z., Schlesinger, Larry S., Singh, Anjali, Spiegel, Hans M.L., Struble, Evi, Sung, Kyung, Tagle, Danilo A., Thacker, Vivek V., Tidball, Andrew M., Varthakavi, Vasundhara, Vunjak-Novakovic, Gordana, Wagar, Lisa E., Yeung, Catherine K., Ndhlovu, Lishomwa C., Ott, Melanie

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