Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner von Honda, Hiroe, Nagai, Yoshinori, Matsunaga, Takayuki, Saitoh, Shin‐ichiro, Akashi‐Takamura, Sachiko, Hayashi, Hiroaki, Fujii, Isao, Miyake, Kensuke, Muraguchi, Atsushi, Takatsu, Kiyoshi

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Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos von Oka, Miho, Hashimoto, Keisuke, Yamaguchi, Yoshifumi, Saitoh, Shin-Ichiro, Sugiura, Yuki, Motoi, Yuji, Honda, Kurara, Kikko, Yorifumi, Ohata, Shinya, Suematsu, Makoto, Miura, Masayuki, Miyake, Kensuke, Katada, Toshiaki, Kontani, Kenji

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Association of SIGNR1 with TLR4–MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria von Nagaoka, Koji, Takahara, Kazuhiko, Tanaka, Kay, Yoshida, Hideo, Steinman, Ralph M., Saitoh, Shin-ichiro, Akashi-Takamura, Sachiko, Miyake, Kensuke, Kang, Young Sun, Park, Chae Gyu, Inaba, Kayo

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Identification of a Novel Transmembrane Semaphorin Expressed on Lymphocytes von Furuyama, Tatsuo, Inagaki, Shinobu, Kosugi, Atsushi, Noda, Satoshi, Saitoh, Shin-ichiro, Ogata, Masato, Iwahashi, Yoshiko, Miyazaki, Nobuo, Hamaoka, Toshiyuki, Tohyama, Masaya

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Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll‐like receptor 4 (TLR4)‐MD‐2 and ligand‐induced TLR4 oligomerization von Saitoh, Shin‐ichiroh, Akashi, Sachiko, Yamada, Takenao, Tanimura, Natsuko, Kobayashi, Makiko, Konno, Kazunori, Matsumoto, Fumi, Fukase, Koichi, Kusumoto, Shoichi, Nagai, Yoshinori, Kusumoto, Yutaka, Kosugi, Atsushi, Miyake, Kensuke

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The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling von Tanaka, Hiroshi, Takebayashi, Shin-ichiro, Sakamoto, Akihisa, Igata, Tomoka, Nakatsu, Yuko, Saitoh, Noriko, Hino, Shinjiro, Nakao, Mitsuyoshi

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Impact of blood glucose abnormalities on outcomes and disease severity in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis von Kushimoto, Shigeki, Abe, Toshikazu, Ogura, Hiroshi, Shiraishi, Atsushi, Saitoh, Daizoh, Fujishima, Seitaro, Mayumi, Toshihiko, Hifumi, Toru, Shiino, Yasukazu, Nakada, Taka-Aki, Tarui, Takehiko, Otomo, Yasuhiro, Okamoto, Kohji, Umemura, Yutaka, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-Ichiro, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Hagiwara, Akiyoshi, Yamakawa, Kazuma, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Fujimi, Satoshi, Gando, Satoshi

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Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation von Omori, Satoshi, Tsugita, Misato, Hoshikawa, Yasuto, Morita, Masanobu, Ito, Fumiya, Yamaguchi, Shin-Ichiro, Xie, Qilin, Noyori, Osamu, Yamaguchi, Tomoya, Takada, Ayato, Saitoh, Tatsuya, Toyokuni, Shinya, Akiba, Hisaya, Nagata, Shigekazu, Kinoshita, Kengo, Nakayama, Masafumi

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Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients von Wada, Takeshi, Shiraishi, Atsushi, Gando, Satoshi, Yamakawa, Kazuma, Fujishima, Seitaro, Saitoh, Daizoh, Kushimoto, Shigeki, Ogura, Hiroshi, Abe, Toshikazu, Mayumi, Toshihiko, Sasaki, Junichi, Kotani, Joji, Takeyama, Naoshi, Tsuruta, Ryosuke, Takuma, Kiyotsugu, Yamashita, Norio, Shiraishi, Shin-ichiro, Ikeda, Hiroto, Shiino, Yasukazu, Tarui, Takehiko, Nakada, Taka-aki, Hifumi, Toru, Okamoto, Kohji, Sakamoto, Yuichiro, Hagiwara, Akiyoshi, Masuno, Tomohiko, Ueyama, Masashi, Fujimi, Satoshi, Umemura, Yutaka, Otomo, Yasuhiro

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Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis von Furuichi, Tatsuya, Kanemoto, Soshi, Okabe, Masaru, Saitoh, Masahiro, Ikegawa, Shiro, Saito, Atsushi, Yoneda, Toshiyuki, Hino, Shin-ichiro, Nishimura, Riko, Ikawa, Masahito, Murakami, Tomohiko, Kondo, Shinichi, Imaizumi, Kazunori

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Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan von Umemura, Yutaka, Abe, Toshikazu, Ogura, Hiroshi, Fujishima, Seitato, Kushimoto, Shigeki, Shiraishi, Atsushi, Saitoh, Daizoh, Mayumi, Toshihiko, Otomo, Yasuhiro, Hifumi, Toru, Hagiwara, Akiyoshi, Takuma, Kiyotsugu, Yamakawa, Kazuma, Shiino, Yasukazu, Nakada, Taka-Aki, Tarui, Takehiko, Okamoto, Kohji, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-Ichiro, Tsuruta, Ryosuke, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Gando, Satoshi

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Effects of tranexamic acid on coagulofibrinolytic markers during the early stage of severe trauma: A propensity score–matched analysis von Gando, Satoshi, Shiraishi, Atsushi, Wada, Takeshi, Yamakawa, Kazuma, Fujishima, Seitaro, Saitoh, Daizoh, Kushimoto, Shigeki, Ogura, Hiroshi, Abe, Toshikazu, Mayumi, Toshihiko, Sasaki, Junichi, Kotani, Joji, Takeyama, Naoshi, Tsuruta, Ryosuke, Takuma, Kiyotsugu, Shiraishi, Shin-ichiro, Shiino, Yasukazu, Nakada, Taka-aki, Okamoto, Kohji, Sakamoto, Yuichiro, Hagiwara, Akiyoshi, Fujimi, Satoshi, Umemura, Yutaka, Otomo, Yasuhiro

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Current spectrum of causative pathogens in sepsis: A prospective nationwide cohort study in Japan von Umemura, Yutaka, Ogura, Hiroshi, Takuma, Kiyotsugu, Fujishima, Seitato, Abe, Toshikazu, Kushimoto, Shigeki, Hifumi, Toru, Hagiwara, Akiyoshi, Shiraishi, Atsushi, Otomo, Yasuhiro, Saitoh, Daizoh, Mayumi, Toshihiko, Yamakawa, Kazuma, Shiino, Yasukazu, Nakada, Taka-aki, Tarui, Takehiko, Okamoto, Kohji, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-ichiro, Tsuruta, Ryosuke, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Gando, Satoshi

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A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis von Gando, Satoshi, Saitoh, Daizoh, Ogura, Hiroshi, Fujishima, Seitaro, Mayumi, Toshihiko, Araki, Tsunetoshi, Ikeda, Hiroto, Kotani, Joji, Kushimoto, Shigeki, Miki, Yasuo, Shiraishi, Shin-ichiro, Suzuki, Koichiro, Suzuki, Yasushi, Takeyama, Naoshi, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Yamaguchi, Yoshihiro, Yamashita, Norio, Aikawa, Naoki

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The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome von Gando, Satoshi, Fujishima, Seitaro, Saitoh, Daizoh, Shiraishi, Atsushi, Yamakawa, Kazuma, Kushimoto, Shigeki, Ogura, Hiroshi, Abe, Toshikazu, Mayumi, Toshihiko, Sasaki, Junichi, Kotani, Joji, Takeyama, Naoshi, Tsuruta, Ryosuke, Takuma, Kiyotsugu, Yamashita, Norio, Shiraishi, Shin-ichiro, Ikeda, Hiroto, Shiino, Yasukazu, Tarui, Takehiko, Nakada, Taka-aki, Hifumi, Toru, Otomo, Yasuhiro, Okamoto, Kohji, Sakamoto, Yuichiro, Hagiwara, Akiyoshi, Masuno, Tomohiko, Ueyama, Masashi, Fujimi, Satoshi, Umemura, Yutaka

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Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study von Abe, Toshikazu, Ogura, Hiroshi, Shiraishi, Atsushi, Kushimoto, Shigeki, Saitoh, Daizoh, Fujishima, Seitaro, Mayumi, Toshihiko, Shiino, Yasukazu, Nakada, Taka-Aki, Tarui, Takehiko, Hifumi, Toru, Otomo, Yasuhiro, Okamoto, Kohji, Umemura, Yutaka, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-Ichiro, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Hagiwara, Akiyoshi, Yamakawa, Kazuma, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Fujimi, Satoshi, Gando, Satoshi

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Flexible Coordination Polymers Composed of Luminescent Ruthenium(II) Metalloligands: Importance of the Position of the Coordination Site in Metalloligands von Kobayashi, Atsushi, Ohba, Tadashi, Saitoh, Erika, Suzuki, Yui, Noro, Shin-ichiro, Chang, Ho-Chol, Kato, Masako

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Role of disseminated intravascular coagulation in severe sepsis von Gando, Satoshi, Shiraishi, Atsushi, Yamakawa, Kazuma, Ogura, Hiroshi, Saitoh, Daizoh, Fujishima, Seitaro, Mayumi, Toshihiko, Kushimoto, Shigeki, Abe, Toshikazu, Shiino, Yasukazu, Nakada, Taka-aki, Tarui, Takehiko, Hifumi, Toru, Otomo, Yasuhiro, Okamoto, Kohji, Umemura, Yutaka, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-ichiro, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Hagiwara, Akiyoshi, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Fujimi, Satoshi, Tasaki, Osamu, Mizobata, Yasumitsu, Funakoshi, Hiraku, Okuyama, Toshiro, Yamashita, Iwao, Kanai, Toshio, Yamada, Yasuo, Aibiki, Mayuki, Sato, Keiji, Yamashita, Susumu, Yamashita, Susumu, Yoshida, Kenichi, Kasaoka, Shunji, Kon, Akihide, Rinka, Hiroshi, Kato, Hiroshi, Okudera, Hiroshi, Narimatsu, Eichi, Fujiwara, Toshifumi, Sugita, Manabu, Shichinohe, Yasuo, Nakae, Hajime, Iiduka, Ryouji, Murata, Yuji, Nakamura, Mitsunobu, Sato, Yoshitake, Ishikura, Hiroyasu, Myojo, Yasuhiro, Tsujita, Yasuyuki, Kinoshita, Kosaku, Yamaguchi, Hiroyuki, Sakurai, Toshihiro, Miyatake, Satoru, Saotome, Takao, Yasuda, Susumu, Abe, Toshikazu, Ogura, Hiroshi, Umemura, Yutaka, Shiraishi, Atsushi, Kushimoto, Shigeki, Saitoh, Daizoh, Fujishima, Seitaro, Sasaki, Junichi, Mayumi, Toshihiko, Shiino, Yasukazu, Nakada, Taka-aki, Tarui, Takehiko, Hifumi, Toru, Otomo, Yasuhiro, Kotani, Joji, Sakamoto, Yuichiro, Shiraishi, Shin-ichiro, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Hagiwara, Akiyoshi, Yamakawa, Kazuma, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Mizushima, Yasuaki, Gando, Satoshi

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Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis von Wada, Takeshi, Yamakawa, Kazuma, Kabata, Daijiro, Abe, Toshikazu, Ogura, Hiroshi, Shiraishi, Atsushi, Saitoh, Daizoh, Kushimoto, Shigeki, Fujishima, Seitaro, Mayumi, Toshihiko, Hifumi, Toru, Shiino, Yasukazu, Nakada, Taka-aki, Tarui, Takehiko, Otomo, Yasuhiro, Okamoto, Kohji, Umemura, Yutaka, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-ichiro, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Hagiwara, Akiyoshi, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Fujimi, Satoshi, Gando, Satoshi

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The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis von Kushimoto, Shigeki, Gando, Satoshi, Saitoh, Daizoh, Mayumi, Toshihiko, Ogura, Hiroshi, Fujishima, Seitaro, Araki, Tsunetoshi, Ikeda, Hiroto, Kotani, Joji, Miki, Yasuo, Shiraishi, Shin-ichiro, Suzuki, Koichiro, Suzuki, Yasushi, Takeyama, Naoshi, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Yamaguchi, Yoshihiro, Yamashita, Norio, Aikawa, Naoki

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