Antagonists show GTP‐sensitive high‐affinity binding to the sigma‐1 receptor von Brimson, JM, Brown, CA, Safrany, ST

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Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates von Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C, Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan MF

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Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo von SPRUCE, Barbara A, CAMPBELL, Lorna A, MCLEAN, Doris, LESLIE, Nick R, SAFRANY, Stephen T, FERGUSON, Michelle J, PETERS, John A, PRESCOTT, Alan R, BOX, Gary, HAYES, Angela, NUTLEY, Bernard, RAYNAUD, Florence, MCTAVISH, Niall, DOWNES, C. Peter, LAMBERT, Jeremy J, THOMPSON, Alastair M, ECCLES, Suzanne, COOPER, Michelle A, APPLEYARD, M. Virginia L, O'NEILL, Mary, HOWIE, Jacqueline, SAMSON, Jayne, WATT, Stephen, MURRAY, Karen

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A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase von Safrany, Stephen T., Caffrey, James J., Yang, Xiaonian, Bembenek, Michael E., Moyer, Mary B., Burkhart, William A., Shears, Stephen B.

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Protocols for Regulation and Study of Diphosphoinositol Polyphosphates von Safrany, S T

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Nudix Hydrolases That Degrade Dinucleoside and Diphosphoinositol Polyphosphates Also Have 5-Phosphoribosyl 1-Pyrophosphate (PRPP) Pyrophosphatase Activity That Generates the Glycol... von Fisher, David I., Safrany, Stephen T., Strike, Peter, McLennan, Alexander G., Cartwright, Jared L.

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diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overl... von Safrany, S.T, Ingram, S.W, Cartwright, J.L, Falck, J.R, McLennan, A.G, Barness, L.D, Shears, S.B

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Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family von Caffrey, J J, Safrany, S T, Yang, X, Shears, S B

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The g5R (D250) Gene of African Swine Fever Virus Encodes a Nudix Hydrolase That Preferentially Degrades Diphosphoinositol Polyphosphates von Cartwright, Jared L, Safrany, Stephen T, Dixon, Linda K, Darzynkiewicz, Edward, Stepinski, Janusz, Burke, Richard, McLennan, Alexander G

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Site-directed Mutagenesis of Diphosphoinositol Polyphosphate Phosphohydrolase, a Dual Specificity NUDT Enzyme That Attacks Diadenosine Polyphosphates and Diphosphoinositol Polyphos... von Yang, X, Safrany, S T, Shears, S B

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Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase von Craxton, A, Caffrey, J J, Burkhart, W, Safrany, S T, Shears, S B

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Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells von Albert, C, Safrany, S T, Bembenek, M E, Reddy, K M, Reddy, K, Falck, J, Bröcker, M, Shears, S B, Mayr, G W

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Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5 double prime -P super(1),P super... von Ingram, S W, Safrany, ST, Barnes, L D

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Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research? von Safrany, S. T., Caffrey, J. J., Yang, X., Shears, S. B.

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PTEN M-CBR3, a Versatile and Selective Regulator of Inositol 1,3,4,5,6- Pentakisphosphate (Ins(1,3,4,5,6)P sub(5)): Evidence for Ins(1,3,4,5,6)P sub(5) as a proliferative signal von Orchiston, E A, Bennett, D, Leslie, N R, Clarke, R G, Winward, L, Downes, C P, Safrany, ST

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The g5R (D250) Gene of African Swine Fever Virus Encodes a Nudix Hydrolase That Preferentially Degrades Diphosphoinositol Polyphosphates von Cartwright, Jared L., Safrany, Stephen T., Dixon, Linda K., Darzynkiewicz, Edward, Stepinski, Janusz, Burke, Richard, McLennan, Alexander G.

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Identification of partial agonists with low intrinsic activity at the inositol-1,4,5-trisphosphate receptor von SAFRANY, S. T, WILCOX, R. A, LIU, C, DUBREUIL, D, POTTER, B. V. L, NAHORSKI, S. R

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A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells von Safrany, S T, Nahorski, S R

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Interaction of synthetic D-6-deoxy- myo-inositol 1,4,5-trisphosphate with the Ca 2+-releasing D- myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase... von Safrany, S.T., Wojcikiewicz, R.J.H., Strupish, J., Nahorski, S.R., Dubreuil, D., Cleophax, J., Gero, S.D., Potter, B.V.L.

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Synthetic phosphorothioate-containing analogues of inositol 1,4,5-trisphosphate mobilize intracellular Ca2+ stores and interact differentially with inositol 1,4,5-trisphosphate 5-p... von Safrany, S T, Wojcikiewicz, R J, Strupish, J, McBain, J, Cooke, A M, Potter, B V, Nahorski, S R

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