Antagonists show GTP‐sensitive high‐affinity binding to the sigma‐1 receptor von Brimson, JM, Brown, CA, Safrany, ST

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Are fluoxetine’s effects due to sigma-1 receptor agonism? von Safrany, S.T., Brimson, J.M.

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A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase von Safrany, Stephen T., Caffrey, James J., Yang, Xiaonian, Bembenek, Michael E., Moyer, Mary B., Burkhart, William A., Shears, Stephen B.

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Protocols for Regulation and Study of Diphosphoinositol Polyphosphates von Safrany, S T

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Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research? von Safrany, S. T., Caffrey, J. J., Yang, X., Shears, S. B.

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Identification of partial agonists with low intrinsic activity at the inositol-1,4,5-trisphosphate receptor von SAFRANY, S. T, WILCOX, R. A, LIU, C, DUBREUIL, D, POTTER, B. V. L, NAHORSKI, S. R

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diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overl... von Safrany, S.T, Ingram, S.W, Cartwright, J.L, Falck, J.R, McLennan, A.G, Barness, L.D, Shears, S.B

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Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family von Caffrey, J J, Safrany, S T, Yang, X, Shears, S B

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Site-directed Mutagenesis of Diphosphoinositol Polyphosphate Phosphohydrolase, a Dual Specificity NUDT Enzyme That Attacks Diadenosine Polyphosphates and Diphosphoinositol Polyphos... von Yang, X, Safrany, S T, Shears, S B

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Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase von Craxton, A, Caffrey, J J, Burkhart, W, Safrany, S T, Shears, S B

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Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells von Albert, C, Safrany, S T, Bembenek, M E, Reddy, K M, Reddy, K, Falck, J, Bröcker, M, Shears, S B, Mayr, G W

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Synthetic phosphorothioate-containing analogues of inositol 1,4,5-trisphosphate mobilize intracellular Ca2+ stores and interact differentially with inositol 1,4,5-trisphosphate 5-p... von Safrany, S T, Wojcikiewicz, R J, Strupish, J, McBain, J, Cooke, A M, Potter, B V, Nahorski, S R

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Deoxygenated inositol 1,4,5-trisphosphate analogs and their interaction with metabolic enzymes. (1R,2R,4R)-Cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphat... von Kozikowski, Alan P, Ognyanov, Vassil I, Chen, Chinpiao, Fauq, Abdul H, Safrany, Stephen T, Wilcox, Robert A, Nahorski, Stefan R

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Muscarinic receptors, phosphoinositide metabolism and intracellular calcium in neuronal cells von Lambert, David G., Wojcikiewicz, Richard J.H., Safrany, Stephen T., Whitham, Emma M., Nahorski, Stefan R.

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Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? von Strupish, J, Wojcikiewicz, R J, Challiss, R A, Safrany, S T, Willcocks, A L, Potter, B V, Nahorski, S R

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Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates von Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C, Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan MF

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Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo von SPRUCE, Barbara A, CAMPBELL, Lorna A, MCLEAN, Doris, LESLIE, Nick R, SAFRANY, Stephen T, FERGUSON, Michelle J, PETERS, John A, PRESCOTT, Alan R, BOX, Gary, HAYES, Angela, NUTLEY, Bernard, RAYNAUD, Florence, MCTAVISH, Niall, DOWNES, C. Peter, LAMBERT, Jeremy J, THOMPSON, Alastair M, ECCLES, Suzanne, COOPER, Michelle A, APPLEYARD, M. Virginia L, O'NEILL, Mary, HOWIE, Jacqueline, SAMSON, Jayne, WATT, Stephen, MURRAY, Karen

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A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells von Safrany, S T, Nahorski, S R

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Sigma Receptors

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Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: Identification... von Safrany, Stephen T., Sawyer, Deborah A., Nahorski, Stefan R., Potter, Barry V.L.

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