Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets von Mathur, L., Szalai, B., Du, N. H., Utharala, R., Ballinger, M., Landry, J. J. M., Ryckelynck, M., Benes, V., Saez-Rodriguez, J., Merten, C. A.

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Dissecting the puzzle of life: modularization of signal transduction networks von Saez-Rodriguez, J., Kremling, A., Gilles, E.D.

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Systems biology—An engineering perspective von Kremling, A., Saez-Rodriguez, J.

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Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition von Mateo, F, Arenas, E J, Aguilar, H, Serra-Musach, J, de Garibay, G Ruiz, Boni, J, Maicas, M, Du, S, Iorio, F, Herranz-Ors, C, Islam, A, Prado, X, Llorente, A, Petit, A, Vidal, A, Català, I, Soler, T, Venturas, G, Rojo-Sebastian, A, Serra, H, Cuadras, D, Blanco, I, Lozano, J, Canals, F, Sieuwerts, A M, de Weerd, V, Look, M P, Puertas, S, García, N, Perkins, A S, Bonifaci, N, Skowron, M, Gómez-Baldó, L, Hernández, V, Martínez-Aranda, A, Martínez-Iniesta, M, Serrat, X, Cerón, J, Brunet, J, Barretina, M P, Gil, M, Falo, C, Fernández, A, Morilla, I, Pernas, S, Plà, M J, Andreu, X, Seguí, M A, Ballester, R, Castellà, E, Nellist, M, Morales, S, Valls, J, Velasco, A, Matias-Guiu, X, Figueras, A, Sánchez-Mut, J V, Sánchez-Céspedes, M, Cordero, A, Gómez-Miragaya, J, Palomero, L, Gómez, A, Gajewski, T F, Cohen, E E W, Jesiotr, M, Bodnar, L, Quintela-Fandino, M, López-Bigas, N, Valdés-Mas, R, Puente, X S, Viñals, F, Casanovas, O, Graupera, M, Hernández-Losa, J, Ramón y Cajal, S, García-Alonso, L, Saez-Rodriguez, J, Esteller, M, Sierra, A, Martín-Martín, N, Matheu, A, Carracedo, A, González-Suárez, E, Nanjundan, M, Cortés, J, Lázaro, C, Odero, M D, Martens, J W M, Moreno-Bueno, G, Barcellos-Hoff, M H, Villanueva, A, Gomis, R R, Pujana, M A

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A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models von Ryll, A., Bucher, J., Bonin, A., Bongard, S., Gonçalves, E., Saez-Rodriguez, J., Niklas, J., Klamt, S.

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Logic modelling of toxicology pathways von Gabor, A, Saez-Rodriguez, J.

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S887 DISSECTING THE ROLE OF CXCL4 IN PRIMARY MYELOFIBROSIS von Gleitz, H., Dugourd, A., Leimkühler, N., Snoeren, I., Fuchs, S., Banjanin, B., Pritchard, J., Hoogenboezem, R., Bindels, E., Saez‐Rodriguez, J., Kramann, R., Schneider, R.

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Dynamic transcription factor activity and networks during ErbB2 breast oncogenesis and targeted therapy von Weiss, M S, Peñalver Bernabé, B, Shin, S, Asztalos, S, Dubbury, S J, Mui, M D, Bellis, A D, Bluver, D, Tonetti, D A, Saez-Rodriguez, J, Broadbelt, L J, Jeruss, J S, Shea, L D

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SPOT-012 Large-scale CRISPR screening to identify actionable cancer drug targets von Behan, F, Iorio, F, Stronach, E, Beaver, C, Santos, R Moita, Saez-Rodriguez, J, Yusa, K, Garnett, M

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34 Gene fusions in 1,015 human cancer cell lines: integrating large-scale genomic data, high-throughput drug and CRISPR/Cas9 screens to assess functional relevance and therapeutic... von Chen, E, Picco, G, Garcia-Alonso, L, Bignell, G, Behan, F, Matchan, A, Iorio, F, Stronach, E, Saez-Rodriguez, J, Garnett, M

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Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system von Schäfer, Philipp Sven Lars, Dimitrov, Daniel, Villablanca, Eduardo J., Saez-Rodriguez, Julio

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A methodology for the structural and functional analysis of signaling and regulatory networks von Klamt, Steffen, Saez-Rodriguez, Julio, Lindquist, Jonathan A, Simeoni, Luca, Gilles, Ernst D

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A meta-analysis of the transcriptional landscape of end stage heart failure with reduced ejection fraction von Lanzer, J, Ramirez-Flores, R, Schultz, J.H, Levinson, R, Saez-Rodriguez, J

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P-319 Opposite functional alterations between aged endometria and that of women with uterine disorders offer plausible explanations to the increased incidence of uterine disorders... von Devesa Peiro, A, Sebastian-Leon, P, Garcia-Garcia, F, Pellicer, A, Saez-Rodriguez, J, Diaz-Gimeno, P

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Partial myeloid inhibition of key glycolytic enzyme PFKFB3 increases hepatic steatosis and inflammation, but does not affect atherosclerosis von Tillie, R., De Bruijn, J., Dobie, R., Perales-Patón, J., Van Kuijk, K., Gijbels, M., Temmerman, L., Ghosheh, Y., Goossens, G., Carmeliet, P., Ley, K., Henderson, N., Saez-Rodriguez, J., Wouters, K., Sluimer, J.

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S-25-02 Gene co-expression network analysis of toxicogenomic data linked to histopathology provides quantitative mode-of-action assessment and prediction of drug-induced organ toxi... von Kunnen, S.J., Callegaro, G., Wijaya, L.S., Trairatphisan, P., Mollon, J., Grosdidier, S., Webster, Y.W., Saez-Rodriguez, J., Stevens, J.L., van de Water, B.

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Deficiency of myeloid prolyl hydroxylase domain proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling von Sluimer, J, Van Kuijk, K, Demandt, J A F, Perales-Paton, J, Kuppe, C, Jin, H, Matic, L, Mees, B, Hedin, U, Biessen, E A L, Carmeliet, P, Baker, A H, Kramann, R K, Schurgers, L J, Saez-Rodriguez, J

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P020 Mapping the changing intercellular communication and its downstream effect in Ulcerative Colitis von Potari-gul, L, Modos, D, Turei, D, Valdeolivas, A, Madgwick, M, Saez-Rodriguez, J, Korcsmaros, T

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Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling von Van Kuijk, K., Demandt, J.A., Perales-Paton, J., Theelen, T., Marsch, E., De Bruijn, J., Kuppe, C., Mees, B., Gijbels, M.J.J., Matic, L., Hedin, U., Biessen, E., Kramann, R., Carmeliet, P., Schurgers, L.J., Saez-Rodriguez, J., Sluimer, J.

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Transcription Factor Activity Inference in Systemic Lupus Erythematosus von Lopez-Dominguez, Raul, Toro-Dominguez, Daniel, Martorell-Marugan, Jordi, Garcia-Moreno, Adrian, Holland, Christian H, Saez-Rodriguez, Julio, Goldman, Daniel, Petri, Michelle A, Alarcon-Riquelme, Marta E, Carmona-Saez, Pedro

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