Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction von Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.

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Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein von Ketcham, John M., Harwood, Stephen J., Aranda, Ruth, Aloiau, Athenea N., Bobek, Briana M., Briere, David M., Burns, Aaron C., Caddell Haatveit, Kersti, Calinisan, Andrew, Clarine, Jeffery, Elliott, Adam, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jones, Benjamin, Kuehler, Jon, Lawson, J. David, Nguyen, Natalie, Parker, Cody, Pearson, Kelly E., Rahbaek, Lisa, Saechao, Barbara, Wang, Xiaolun, Waters, Anna, Waters, Laura, Watkins, Ashlee H., Olson, Peter, Smith, Christopher R., Christensen, James G., Marx, Matthew A.

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Abstract ND02: MRTX0902: A SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers von Ketcham, John M., Khare, Shilpi, Sudhakar, Niranjan, Briere, David M., Yan, Larry, Laguer, Jade, Vegar, Laura, Vanderpool, Darin, Hallin, Jill, Hargis, Lauren, Bowcut, Vickie, Lawson, David, Gunn, Robin J., Ivetac, Anthony, Thomas, Nicole C., Saechao, Barbara, Nguyen, Natalie, Clarine, Jeffrey, Rahbaek, Lisa, Smith, Christopher R., Burns, Aaron C., Marx, Matthew A., Christensen, James G., Olson, Peter, Haling, Jacob R.

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Methionine salvage and S-adenosylmethionine: essential links between sulfur, ethylene and polyamine biosynthesis von Sauter, Margret, Moffatt, Barbara, Saechao, Maye Chin, Hell, Rüdiger, Wirtz, Markus

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