Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity von Westcott, Peter M. K., Muyas, Francesc, Hauck, Haley, Smith, Olivia C., Sacks, Nathan J., Ely, Zackery A., Jaeger, Alex M., Rideout, William M., Zhang, Daniel, Bhutkar, Arjun, Beytagh, Mary C., Canner, David A., Jaramillo, Grissel C., Bronson, Roderick T., Naranjo, Santiago, Jin, Abbey, Patten, J. J., Cruz, Amanda M., Shanahan, Sean-Luc, Cortes-Ciriano, Isidro, Jacks, Tyler

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Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer von Westcott, Peter M K, Sacks, Nathan J, Schenkel, Jason M, Ely, Zackery A, Smith, Olivia, Hauck, Haley, Jaeger, Alex M, Zhang, Daniel, Backlund, Coralie M, Beytagh, Mary C, Patten, J J, Elbashir, Ryan, Eng, George, Irvine, Darrell J, Yilmaz, Omer H, Jacks, Tyler

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Abstract 3447: T cell antigen expression levels govern progression and therapy response in a novel model of colon cancer von Westcott, Peter Maxwell Kienitz, Sacks, Nathan J., Smith, Olivia, Schenkel, Jason, Ely, Zackery, Zhang, Daniel, Beytagh, Mary Clare, Hwang, William, Eng, George, Roper, Jatin, Yilmaz, Omer, Jacks, Tyler

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Abstract P023: Mismatch repair deficiency is not sufficient to increase tumor immunogenicity von Westcott, Peter M. K., Remolar, Francesc M., Smith, Olivia, Hauck, Haley, Sacks, Nathan J., Ely, Zackery A., Jaeger, Alex M., Rideout, William M., Bhutkar, Arjun, Zhang, Daniel, Beytagh, Mary C., Bronson, Roderick T., Canner, David A., Naranjo, Santiago, Jin, Abbey, Patten, J. J., Cruz, Amanda M., Cortes-Ciriano, Isidro, Jacks, Tyler

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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials von Mega, Jessica L, Dr, Stitziel, Nathan O, Dr, Smith, J Gustav, MD, Chasman, Daniel I, PhD, Caulfield, Mark J, Prof, Devlin, James J, PhD, Nordio, Francesco, PhD, Hyde, Craig L, PhD, Cannon, Christopher P, Prof, Sacks, Frank M, Prof, Poulter, Neil R, Prof, Sever, Peter S, Prof, Ridker, Paul M, Prof, Braunwald, Eugene, Prof, Melander, Olle, Prof, Kathiresan, Sekar, MD, Sabatine, Marc S, Prof

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Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection von Peters, Nathan C, Pagán, Antonio J, Lawyer, Phillip G, Hand, Timothy W, Henrique Roma, Eric, Stamper, Lisa W, Romano, Audrey, Sacks, David L

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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design von Rokita, Jo Lynne, Rathi, Komal S., Cardenas, Maria F., Upton, Kristen A., Jayaseelan, Joy, Cross, Katherine L., Pfeil, Jacob, Egolf, Laura E., Way, Gregory P., Farrel, Alvin, Kendsersky, Nathan M., Patel, Khushbu, Gaonkar, Krutika S., Modi, Apexa, Berko, Esther R., Lopez, Gonzalo, Vaksman, Zalman, Mayoh, Chelsea, Nance, Jonas, McCoy, Kristyn, Haber, Michelle, Evans, Kathryn, McCalmont, Hannah, Bendak, Katerina, Böhm, Julia W., Marshall, Glenn M., Tyrrell, Vanessa, Kalletla, Karthik, Braun, Frank K., Qi, Lin, Du, Yunchen, Zhang, Huiyuan, Lindsay, Holly B., Zhao, Sibo, Shu, Jack, Baxter, Patricia, Morton, Christopher, Kurmashev, Dias, Zheng, Siyuan, Chen, Yidong, Bowen, Jay, Bryan, Anthony C., Leraas, Kristen M., Coppens, Sara E., Doddapaneni, HarshaVardhan, Momin, Zeineen, Zhang, Wendong, Sacks, Gregory I., Hart, Lori S., Krytska, Kateryna, Mosse, Yael P., Gatto, Gregory J., Sanchez, Yolanda, Greene, Casey S., Diskin, Sharon J., Vaske, Olena Morozova, Haussler, David, Gastier-Foster, Julie M., Kolb, E. Anders, Gorlick, Richard, Li, Xiao-Nan, Reynolds, C. Patrick, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B., Raman, Pichai, Wheeler, David A., Maris, John M.

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Removal of interscapular brown adipose tissue increases aortic stiffness despite normal systemic glucose metabolism in mice von Grunewald, Zachary I, Winn, Nathan C, Gastecki, Michelle L, Woodford, Makenzie L, Ball, James R, Hansen, Sarah A, Sacks, Harold S, Vieira-Potter, Victoria J, Padilla, Jaume

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Recruitment and remodeling of peridroplet mitochondria in human adipose tissue von Acín-Perez, Rebeca, Petcherski, Anton, Veliova, Michaela, Benador, Ilan Y., Assali, Essam A., Colleluori, Georgia, Cinti, Saverio, Brownstein, Alexandra J., Baghdasarian, Siyouneh, Livhits, Masha J., Yeh, Michael W., Krishnan, Karthickeyan Chella, Vergnes, Laurent, Winn, Nathan C., Padilla, Jaume, Liesa, Marc, Sacks, Harold S., Shirihai, Orian S.

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Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice von Winn, Nathan C, Vieira-Potter, Victoria J, Gastecki, Michelle L, Welly, Rebecca J, Scroggins, Rebecca J, Zidon, Terese M, Gaines, T'Keaya L, Woodford, Makenzie L, Karasseva, Natalia G, Kanaley, Jill A, Sacks, Harold S, Padilla, Jaume

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NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis von Carneiro, Matheus B H, Roma, Eric H, Ranson, Adam J, Doria, Nicole A, Debrabant, Alain, Sacks, David L, Vieira, Leda Q, Peters, Nathan C

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Site-dependent recruitment of inflammatory cells determines the effective dose of Leishmania major von Ribeiro-Gomes, Flavia L, Roma, Eric Henrique, Carneiro, Matheus B H, Doria, Nicole A, Sacks, David L, Peters, Nathan C

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Generalist dispersal and gene flow of an endangered keystone specialist (Dipodomys ingens) von Alexander, Nathan B., Statham, Mark J., Sacks, Benjamin N., Bean, William T.

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A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice von Winn, Nathan C, Acin-Perez, Rebeca, Woodford, Makenzie L, Hansen, Sarah A, Haney, Megan M, Ayedun, Lolade A, Rector, R Scott, Vieira-Potter, Victoria J, Shirihai, Orian S, Sacks, Harold S, Kanaley, Jill A, Padilla, Jaume

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Increased susceptibility to OVX-associated metabolic dysfunction in UCP1-null mice von Clookey, Stephanie L, Welly, Rebecca J, Zidon, Terese M, Gastecki, Michelle L, Woodford, Makenzie L, Grunewald, Zachary I, Winn, Nathan C, Eaton, Dusti, Karasseva, Natalia G, Sacks, Harold S, Padilla, Jaume, Vieira-Potter, Victoria J

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Epigenomic profiling of neuroblastoma cell lines von Upton, Kristen, Modi, Apexa, Patel, Khushbu, Kendsersky, Nathan M., Conkrite, Karina L., Sussman, Robyn T., Way, Gregory P., Adams, Rebecca N., Sacks, Gregory I., Fortina, Paolo, Diskin, Sharon J., Maris, John M., Rokita, Jo Lynne

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Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction von Winn, Nathan C, Grunewald, Zachary I, Gastecki, Michelle L, Woodford, Makenzie L, Welly, Rebecca J, Clookey, Stephanie L, Ball, James R, Gaines, T'Keaya L, Karasseva, Natalia G, Kanaley, Jill A, Sacks, Harold S, Vieira-Potter, Victoria J, Padilla, Jaume

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Historical Population Size Change and Differentiation of Relict Populations of the Endangered Giant Kangaroo Rat von Statham, Mark J, Bean, William T, Alexander, Nathan, Westphal, Michael F, Sacks, Benjamin N

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Cryogenic thermonuclear fuel implosions on the National Ignition Facility von Glenzer, S. H., MacKinnon, A. J., Kline, J. L., Grim, G., Alger, E. T., Berger, R. L., Bernstein, L. A., Betti, R., Bradley, D. K., Burkhart, S. C., Burr, R., Caggiano, J. A., Castro, C., Casey, D. T., Choate, C., Clark, D. S., Cerjan, C. J., Collins, G. W., Dewald, E. L., DiNicola, P., DiNicola, J. M., Dixit, S., Dzenitis, E., Eckart, M., Erbert, G., Frank, M., Frenje, L. J. A., Friedrich, S., Casey, D. T., Gatu Johnson, M., Gibson, C., Giraldez, E., Glebov, V., Glenn, S., Guler, N., Haan, S. W., Haid, B. J., Hammel, B. A., Hamza, A. V., Haynam, C. A., Hermann, H. W., Hicks, D. G., Hinkel, D. E., Holder, J. P., Holunda, D. M., Horner, J. B., Hsing, W. W., Huang, H., Izumi, N., Jackson, M., Jones, O. S., Kauffman, R., Kilkenny, J. D., Kirkwood, R. K., Klingmann, J., Kohut, T., Knauer, J. P., Koch, J. A., Kozioziemki, B., Kritcher, A. L., La Fortune, K., LaTray, D., Lindl, J. D., Ma, T., MacPhee, A. G., Malsbury, T. N., Mapoles, E., Marshall, C. D., Meezan, N. B., Michel, P., Moody, J. D., Moore, A. S., Moran, M., Moreno, K. A., Munro, D. H., Nikroo, A., Pak, A. E., Parham, T., Rinderknecht, H., Regan, S. P., Robey, H. F., Rosen, M. D., Sacks, R., Saunders, R., Sater, J., Séguin, F. H., Stoeffl, W., Suter, L. J., Tommasini, R., Town, R. P. J., Walters, C., Weaver, S., Wegner, P. J., Whitman, P. K., Widmayer, C. C., Wilson, D. C., Van Wonterghem, B., Atherton, L. J., Edwards, M. J., Moses, E. I.

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Tracking antigen‐specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice von Pagán, Antonio J., Peters, Nathan C., Debrabant, Alain, Ribeiro‐Gomes, Flavia, Pepper, Marion, Karp, Christopher L., Jenkins, Marc K., Sacks, David L.

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