High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer's Disease in Human Cerebrospinal Fluid von Hendrickson, Ronald C, Lee, Anita Y H, Song, Qinghua, Liaw, Andy, Wiener, Matt, Paweletz, Cloud P, Seeburger, Jeffrey L, Li, Jenny, Meng, Fanyu, Deyanova, Ekaterina G, Mazur, Matthew T, Settlage, Robert E, Zhao, Xuemei, Southwick, Katie, Du, Yi, Holder, Dan, Sachs, Jeffrey R, Laterza, Omar F, Dallob, Aimee, Chappell, Derek L, Snyder, Karen, Modur, Vijay, King, Elizabeth, Joachim, Catharine, Bondarenko, Andrey Y, Shearman, Mark, Soper, Keith A, Smith, A David, Potter, William Z, Koblan, Ken S, Sachs, Alan B, Yates, Nathan A

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Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment von Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura

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Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E von Gross, John D., Moerke, Nathan J., von der Haar, Tobias, Lugovskoy, Alexey A., Sachs, Alan B., McCarthy, John E.G., Wagner, Gerhard

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Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses von Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura

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Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes von Sachs, Alan B, Sarnow, Peter, Hentze, Matthias W

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siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids[S] von Tadin-Strapps, Marija, Peterson, Laurence B., Cumiskey, Anne-Marie, Rosa, Raymond L., Mendoza, Vivienne Halili, Castro-Perez, Jose, Puig, Oscar, Zhang, Liwen, Strapps, Walter R., Yendluri, Satyasri, Andrews, Lori, Pickering, Victoria, Rice, Julie, Luo, Lily, Chen, Zhu, Tep, Samnang, Ason, Brandon, Somers, Elizabeth Polizzi, Sachs, Alan B., Bartz, Steven R., Tian, Jenny, Chin, Jayne, Hubbard, Brian K., Wong, Kenny K., Mitnaul, Lyndon J.

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Glucose depletion rapidly inhibits translation initiation in yeast von Ashe, M P, De Long, S K, Sachs, A B

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MicroRNA-like off-target transcript regulation by siRNAs is species specific von Burchard, Julja, Jackson, Aimee L, Malkov, Vladislav, Needham, Rachel H V, Tan, Yejun, Bartz, Steven R, Dai, Hongyue, Sachs, Alan B, Linsley, Peter S

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Quantitative evaluation of siRNA delivery in vivo von Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F

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RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice von Wei, Jie, Jones, Jeffrey, Kang, Jing, Card, Ananda, Krimm, Michael, Hancock, Paula, Pei, Yi, Ason, Brandon, Payson, Elmer, Dubinina, Natalya, Cancilla, Mark, Stroh, Mark, Burchard, Julja, Sachs, Alan B, Hochman, Jerome H, Flanagan, W Michael, Kuklin, Nelly A

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Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S] von Ason, Brandon, Tep, Samnang, Davis, Jr. Harry R., Xu, Yiming, Tetzloff, Glen, Galinski, Beverly, Soriano, Ferdie, Dubinina, Natalya, Zhu, Lei, Stefanni, Alice, Wong, Kenny K., Tadin-Strapps, Marija, Bartz, Steven R., Hubbard, Brian, Ranalletta, Mollie, Sachs, Alan B., Flanagan, W. Michael, Strack, Alison, Kuklin, Nelly A.

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LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease von Majercak, John, Ray, William J., Espeseth, Amy, Simon, Adam, Shi, Xiao-Ping, Wolffe, Carrie, Getty, Krista, Marine, Shane, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Bartz, Steven, Gates, Adam, Xu, Min, Huang, Qian, Ma, Lei, Shughrue, Paul, Burchard, Julja, Colussi, Dennis, Pietrak, Beth, Kahana, Jason, Beher, Dirk, Rosahl, Thomas, Shearman, Mark, Hazuda, Daria, Sachs, Alan B., Koblan, Kenneth S., Seabrook, Guy R., Stone, David J.

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ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5) von Ason, Brandon, Castro-Perez, Jose, Tep, Samnang, Stefanni, Alice, Tadin-Strapps, Marija, Roddy, Thomas, Hankemeier, Thomas, Hubbard, Brian, Sachs, Alan B., Michael Flanagan, W., Kuklin, Nelly A., Mitnaul, Lyndon J.

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Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation von Tarun, S.Z. Jr, Wells, S.E, Deardorff, J.A, Sachs, A.B

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Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery von Shi, Bin, Keough, Ed, Matter, Andrea, Leander, Karen, Young, Stephanie, Carlini, Ed, Sachs, Alan B., Tao, Weikang, Abrams, Marc, Howell, Bonnie, Sepp-Lorenzino, Laura

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One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs von INADA, TOSHIFUMI, WINSTALL, ERIC, TARUN, SALVADOR Z., YATES, JOHN R., SCHIELTZ, DAVE, SACHS, ALAN B.

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Development and characterization of a reconstituted yeast translation initiation system von ALGIRE, MIKKEL A., MAAG, DAVID, SAVIO, PETER, ACKER, MICHAEL G., TARUN, SALVADOR Z., SACHS, ALAN B., ASANO, KATSURA, NIELSEN, KLAUS H., OLSEN, DEANNE S., PHAN, LON, HINNEBUSCH, ALAN G., LORSCH, JON R.

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Circularization of mRNA by Eukaryotic Translation Initiation Factors von Wells, Sandra E., Hillner, Paul E., Vale, Ronald D., Sachs, Alan B.

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Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo von Kenski, Denise M, Cooper, Abby J, Li, Jenny J, Willingham, Aarron T, Haringsma, Henry J, Young, Tracy A, Kuklin, Nelly A, Jones, Jeffrey J, Cancilla, Mark T, McMasters, Daniel R, Mathur, Melina, Sachs, Alan B, Flanagan, W. Michael

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Cell Cycle–Dependent Translation Initiation: IRES Elements Prevail von Sachs, Alan B

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