Distinct proteostasis states drive pharmacologic chaperone susceptibility for cystic fibrosis transmembrane conductance regulator misfolding mutants von McDonald, Eli Fritz, Sabusap, Carleen Mae P, Kim, Minsoo, Plate, Lars

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The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue von Sabusap, Carleen Mae, Joshi, Disha, Simhaev, Luba, Oliver, Kathryn E., Senderowitz, Hanoch, van Willigen, Marcel, Braakman, Ineke, Rab, Andras, Sorscher, Eric J., Hong, Jeong S.

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Elexacaftor/VX-445–mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics von Kim, Minsoo, McDonald, Eli Fritz, Sabusap, Carleen Mae P., Timalsina, Bibek, Joshi, Disha, Hong, Jeong S., Rab, Andras, Sorscher, Eric J., Plate, Lars

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The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis von Duran-Aniotz, Claudia, Poblete, Natalia, Rivera-Krstulovic, Catalina, Ardiles, Álvaro O., Díaz-Hung, Mei Li, Tamburini, Giovanni, Sabusap, Carleen Mae P., Gerakis, Yannis, Cabral-Miranda, Felipe, Diaz, Javier, Fuentealba, Matias, Arriagada, Diego, Muñoz, Ernesto, Espinoza, Sandra, Martinez, Gabriela, Quiroz, Gabriel, Sardi, Pablo, Medinas, Danilo B., Contreras, Darwin, Piña, Ricardo, Lourenco, Mychael V., Ribeiro, Felipe C., Ferreira, Sergio T., Rozas, Carlos, Morales, Bernardo, Plate, Lars, Gonzalez-Billault, Christian, Palacios, Adrian G., Hetz, Claudio

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The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue von Sabusap, Carleen Mae, Joshi, Disha, Simhaev, Luba, Oliver, Kathryn E, Senderowitz, Hanoch, van Willigen, Marcel, Braakman, Ineke, Rab, Andras, Sorscher, Eric J, Hong, Jeong S

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