Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates von Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

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Bioanalytical Assay Strategies for The Development of Antibody–Drug Conjugate Biotherapeutics von Kaur, Surinder, Xu, Keyang, Saad, Ola M, Dere, Randall C, Carrasco-Triguero, Montserrat

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Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry von Xu, Keyang, Liu, Luna, Saad, Ola M., Baudys, Jakub, Williams, Lara, Leipold, Douglas, Shen, Ben, Raab, Helga, Junutula, Jagath R., Kim, Amy, Kaur, Surinder

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Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity ri... von Lee, M Violet, Saad, Ola M, Wong, Sylvia, LaMar, Jason, Kamen, Lynn, Ordonia, Ben, Melendez, Rachel, Hassanzadeh, Azadeh, Chung, Shan, Kaur, Surinder

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Correction to: Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte von Hyung, Suk-Joon, Li, Dongwei, Koppada, Neelima, Kaur, Surinder, Saad, Ola M.

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Compositional Analysis and Quantification of Heparin and Heparan Sulfate by Electrospray Ionization Ion Trap Mass Spectrometry von Saad, Ola M, Leary, Julie A

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Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates von Lee, M. Violet, Kaur, Surinder, Saad, Ola M

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Delineating mechanisms of dissociation for isomeric heparin disaccharides using isotope labeling and ion trap tandem mass spectrometry von SAAD, Ola M, LEARY, Julie A

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Multiplexed Quantitative Analysis of Antibody–Drug Conjugates with Labile CBI-Dimer Payloads In Vivo Using Immunoaffinity LC-MS/MS von Hyung, Suk-Joon, Leipold, Douglas D, Lee, Donna W, Kaur, Surinder, Saad, Ola M

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Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase von Saad, Ola M, Ebel, Heiner, Uchimura, Kenji, Rosen, Steven D, Bertozzi, Carolyn R, Leary, Julie A

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Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte von Hyung, Suk-Joon, Li, Dongwei, Koppada, Neelima, Kaur, Surinder, Saad, Ola M.

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Immunogenicity of antibody–drug conjugates: observations across 8 molecules in 11 clinical trials von Carrasco-Triguero, Montserrat, Dere, Randall C, Milojic-Blair, Marija, Saad, Ola M, Nazzal, Denise, Hong, Kyu, Kaur, Surinder

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Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1 von Chandran, Vineesh Indira, Mansson, Ann-Sofie, Barbachowska, Magdalena, Cerezo-Magana, Myriam, Nodin, Bjorn, Joshi, Bharat, Koppada, Neelima, Saad, Ola M., Gluz, Oleg, Isaksson, Karolin, Borgquist, Signe, Jirstrom, Karin, Nabi, Ivan Robert, Jernstrom, Helena, Belting, Mattias

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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model von Wang-Lin, Shun Xin, Zhou, Chenguang, Kamath, Amrita V, Hong, Kyu, Koppada, Neelima, Saad, Ola M, Carrasco-Triguero, Montserrat, Khojasteh, Cyrus, Deng, Rong

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Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY (R)) Antibody-Drug Conjugate in Sprague Dawley Rats von Yip, Victor, Lee, M. Violet, Saad, Ola M., Ma, Shuguang, Khojasteh, S. Cyrus, Shen, Ben-Quan

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Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys von Lu, Dan, Jin, Jin Yan, Girish, Sandhya, Agarwal, Priya, Li, Dongwei, Prabhu, Saileta, Dere, Randall C., Saad, Ola M., Nazzal, Denise, Koppada, Neelima, Ramanujan, Saroja, Ng, Chee M.

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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics von Sukumaran, Siddharth, Zhang, Crystal, Leipold, Douglas D., Saad, Ola M., Xu, Keyang, Gadkar, Kapil, Samineni, Divya, Wang, Bei, Milojic-Blair, Marija, Carrasco-Triguero, Montserrat, Rubinfeld, Bonnee, Fielder, Paul, Lin, Kedan, Ramanujan, Saroja

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PK Assays for Antibody–Drug Conjugates: Case Study with Ado-Trastuzumab Emtansine von Dere, Randall, Yi, Joo-Hee, Lei, Corinna, Saad, Ola M, Huang, Catherine, Li, Yanhong, Baudys, Jakub, Kaur, Surinder

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Bioanalytical Approaches for Characterizing Catabolism of Antibody–Drug Conjugates von Saad, Ola M, Shen, Ben-Quan, Xu, Keyang, Khojasteh, S Cyrus, Girish, Sandhya, Kaur, Surinder

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2018 White Paper on Recent Issues in Bioanalysis: focus on immunogenicity assays by hybrid LBA/LCMS and regulatory feedback (Part 2 - PK, PD & ADA assays by hybrid LBA/LCMS & regul... von Neubert, Hendrik, Olah, Timothy, Lee, Anita, Fraser, Stephanie, Dodge, Robert, Laterza, Omar, Szapacs, Matthew, Alley, Stephen C, Saad, Ola M, Amur, Shashi, Chen, Linzhi, Cherry, Elana, Cho, Seongeun (Julia), Cludts, Isabelle, Donato, Lorella Di, Edmison, Anna, Ferrari, Luca, Garofolo, Fabio, Haidar, Sam, Hopper, Shirley, Hottenstein, Scott, Ishii-Watabe, Akiko, Kassim, Sean, Kurki, Pekka, Lima Santos, Gustavo Mendes, Miscoria, Gilles, Palandra, Joe, Pedras-Vasconcelos, João, Piccoli, Steven, Rogstad, Sarah, Saito, Yoshiro, Savoie, Natasha, Sikorski, Timothy, Spitz, Susan, Staelens, Ludovicus, Verthelyi, Daniela, Vinter, Stephen, Wadhwa, Meenu, Wang, Yow-Ming, Welink, Jan, Weng, Naidong, Whale, Emma, Woolf, Eric, Wu, Jiang, Yan, Haoheng, Yu, Hongbin, Zhou, Shaolian

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