Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy von JHA, Jay C, GRAY, Stephen P, TOUYZ, Rhian M, COOPER, Mark E, SCHMIDT, Harald H. H. W, JANDELEIT-DAHM, Karin A, BARIT, David, OKABE, Jun, EL-OSTA, Assam, NAMIKOSHI, Tamehachi, THALLAS-BONKE, Vicki, WINGLER, Kirstin, SZYNDRALEWIEZ, Cedric, HERTZ, Freddy

Volltext

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4 von Hanley, Christopher J, Mellone, Massimiliano, Ford, Kirsty, Thirdborough, Steve M, Mellows, Toby, Frampton, Steven J, Smith, David M, Harden, Elena, Szyndralewiez, Cedric, Bullock, Marc, Noble, Fergus, Moutasim, Karwan A, King, Emma V, Vijayanand, Pandurangan, Mirnezami, Alex H, Underwood, Timothy J, Ottensmeier, Christian H, Thomas, Gareth J

Volltext

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis von Gray, Stephen P, Di Marco, Elyse, Okabe, Jun, Szyndralewiez, Cedric, Heitz, Freddy, Montezano, Augusto C, de Haan, Judy B, Koulis, Christine, El-Osta, Assam, Andrews, Karen L, Chin-Dusting, Jaye P F, Touyz, Rhian M, Wingler, Kirstin, Cooper, Mark E, Schmidt, Harald H. H W, Jandeleit-Dahm, Karin A

Volltext

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis von Di Marco, Elyse, Gray, Stephen P., Kennedy, Kit, Szyndralewiez, Cedric, Lyle, Alicia N., Lassègue, Bernard, Griendling, Kathy K., Cooper, Mark E., Schmidt, Harald H.H.W., Jandeleit-Dahm, Karin A.M.

Volltext

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis von Laleu, Benoı̂t, Gaggini, Francesca, Orchard, Mike, Fioraso-Cartier, Laetitia, Cagnon, Laurène, Houngninou-Molango, Sophie, Gradia, Angelo, Duboux, Guillaume, Merlot, Cédric, Heitz, Freddy, Szyndralewiez, Cédric, Page, Patrick

Volltext

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo von Jiang, Joy X., Chen, Xiangling, Serizawa, Nobuko, Szyndralewiez, Cédric, Page, Patrick, Schröder, Katrin, Brandes, Ralf P., Devaraj, Sridevi, Török, Natalie J.

Volltext

Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes von Gorin, Yves, Cavaglieri, Rita C, Khazim, Khaled, Lee, Doug-Yoon, Bruno, Francesca, Thakur, Sachin, Fanti, Paolo, Szyndralewiez, Cédric, Barnes, Jeffrey L, Block, Karen, Abboud, Hanna E

Volltext

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent von Aoyama, Tomonori, Paik, Yong-Han, Watanabe, Sumio, Laleu, Benoît, Gaggini, Francesca, Fioraso-Cartier, Laetitia, Molango, Sophie, Heitz, Freddy, Merlot, Cédric, Szyndralewiez, Cédric, Page, Patrick, Brenner, David A.

Volltext

The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation von Green, David E, Murphy, Tamara C, Kang, Bum-Yong, Kleinhenz, Jennifer M, Szyndralewiez, Cédric, Page, Patrick, Sutliff, Roy L, Hart, C Michael

Volltext

Pre‐clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis von Thannickal, Victor J., Jandeleit‐Dahm, Karin, Szyndralewiez, Cédric, Török, Natalie J.

Volltext

Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD von Hollins, Fay, Sutcliffe, Amanda, Gomez, Edith, Berair, Rachid, Russell, Richard, Szyndralewiez, Cédric, Saunders, Ruth, Brightling, Christopher

Volltext

Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase von Gaillard, Pascale, Jeanclaude-Etter, Isabelle, Ardissone, Vittoria, Arkinstall, Steve, Cambet, Yves, Camps, Montserrat, Chabert, Christian, Church, Dennis, Cirillo, Rocco, Gretener, Denise, Halazy, Serge, Nichols, Anthony, Szyndralewiez, Cedric, Vitte, Pierre-Alain, Gotteland, Jean-Pierre

Volltext

Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism von Garrido-Urbani, Sarah, Jemelin, Stephane, Deffert, Christine, Carnesecchi, Stéphanie, Basset, Olivier, Szyndralewiez, Cédric, Heitz, Freddy, Page, Patrick, Montet, Xavier, Michalik, Liliane, Arbiser, Jack, Rüegg, Curzio, Krause, Karl Heinz, Imhof, Beat A, Imhof, Beat

Volltext

NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma von Wan, Wing-Yan Heidi, PhD, Hollins, Fay, PhD, Haste, Louise, PhD, Woodman, Lucy, PhD, Hirst, Robert A., PhD, Bolton, Sarah, PhD, Gomez, Edith, PhD, Sutcliffe, Amanda, PhD, Desai, Dhananjay, PhD, Chachi, Latifa, PhD, Mistry, Vijay, BSc, Szyndralewiez, Cédric, PhD, Wardlaw, Andrew, PhD, Saunders, Ruth, PhD, O’Callaghan, Christopher, PhD, Andrew, Peter W., PhD, Brightling, Christopher E., PhD, FCCP

Volltext

Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice von Eid, Stéphanie A, El Massry, Mohamed, Hichor, Mehdi, Haddad, Mary, Grenier, Julien, Dia, Batoul, Barakat, Rasha, Boutary, Suzan, Chanal, Johan, Aractingi, Selim, Wiesel, Philippe, Szyndralewiez, Cédric, Azar, Sami T, Boitard, Christian, Zaatari, Ghazi, Eid, Assaad A, Massaad, Charbel

Volltext

NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy von Wilkinson-Berka, Jennifer L, Deliyanti, Devy, Rana, Indrajeetsinh, Miller, Antonia G, Agrotis, Alex, Armani, Roksana, Szyndralewiez, Cédric, Wingler, Kirstin, Touyz, Rhian M, Cooper, Mark E, Jandeleit-Dahm, Karin A, Schmidt, Harald H H W

Volltext

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors von Gaggini, Francesca, Laleu, Benoît, Orchard, Mike, Fioraso-Cartier, Laetitia, Cagnon, Laurène, Houngninou-Molango, Sophie, Gradia, Angelo, Duboux, Guillaume, Merlot, Cédric, Heitz, Freddy, Szyndralewiez, Cédric, Page, Patrick

Volltext

Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactions von Sampson, Natalie, Brunner, Elena, Weber, Anja, Puhr, Martin, Schäfer, Georg, Szyndralewiez, Cedric, Klocker, Helmut

Volltext

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors von Ford, Kirsty, Hanley, Christopher J, Mellone, Massimiliano, Szyndralewiez, Cedric, Heitz, Freddy, Wiesel, Philippe, Wood, Oliver, Machado, Maria, Lopez, Maria-Antoinette, Ganesan, Anusha-Preethi, Wang, Chuan, Chakravarthy, Ankur, Fenton, Tim R, King, Emma V, Vijayanand, Pandurangan, Ottensmeier, Christian H, Al-Shamkhani, Aymen, Savelyeva, Natalia, Thomas, Gareth J

Volltext

Nox4 is a Target for Tuberin Deficiency Syndrome von Shi, Qian, Viswanadhapalli, Suryavathi, Friedrichs, William E., Velagapudi, Chakradhar, Szyndralewiez, Cédric, Bansal, Shweta, Bhat, Manzoor A., Choudhury, Goutam Ghosh, Abboud, Hanna E.

Volltext