Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors von Wilson, Timothy R., Fridlyand, Jane, Yan, Yibing, Penuel, Elicia, Burton, Luciana, Chan, Emily, Peng, Jing, Lin, Eva, Wang, Yulei, Sosman, Jeff, Ribas, Antoni, Li, Jiang, Moffat, John, Sutherlin, Daniel P., Koeppen, Hartmut, Merchant, Mark, Neve, Richard, Settleman, Jeff

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Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21 von Dunshee, Diana Ronai, Bainbridge, Travis W., Kljavin, Noelyn M., Zavala-Solorio, Jose, Schroeder, Amy C., Chan, Ruby, Corpuz, Racquel, Wong, Manda, Zhou, Wei, Deshmukh, Gauri, Ly, Justin, Sutherlin, Daniel P., Ernst, James A., Sonoda, Junichiro

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Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain von Bankar, Girish, Goodchild, Samuel J., Howard, Sarah, Nelkenbrecher, Karen, Waldbrook, Matthew, Dourado, Michelle, Shuart, Noah G., Lin, Sophia, Young, Clint, Xie, Zhiwei, Khakh, Kuldip, Chang, Elaine, Sojo, Luis E., Lindgren, Andrea, Chowdhury, Sultan, Decker, Shannon, Grimwood, Michael, Andrez, Jean-Christophe, Dehnhardt, Christoph M., Pang, Jodie, Chang, Jae H., Safina, Brian S., Sutherlin, Daniel P., Johnson, James P., Hackos, David H., Robinette, C. Lee, Cohen, Charles J.

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Activation of caspases-8 and -10 by FLIPL von BOATRIGHT, Kelly M., DEIS, Cristina, DENAULT, Jean-Bernard, SUTHERLIN, Daniel P., SALVESEN, Guy S.

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Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer von Sutherlin, Daniel P, Sampath, Deepak, Berry, Megan, Castanedo, Georgette, Chang, Zhigang, Chuckowree, Irina, Dotson, Jenna, Folkes, Adrian, Friedman, Lori, Goldsmith, Richard, Heffron, Tim, Lee, Leslie, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wiesmann, Christian, Wong, Susan, Zhu, Bing-Yan

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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor von Heffron, Timothy P., Berry, Megan, Castanedo, Georgette, Chang, Christine, Chuckowree, Irina, Dotson, Jennafer, Folkes, Adrian, Gunzner, Janet, Lesnick, John D., Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Peterson, David, Salphati, Laurent, Sampath, Deepak, Sideris, Steve, Sutherlin, Daniel P., Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wong, Susan, Zhu, Bing-yan

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Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist von Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Ho, Hoangdung, Shriver, Stephanie, Young, Clint, Lin, Sophia, Johnson, J. P., Wu, Ping, Li, Jun, Coons, Mary, Tam, Christine, Brillantes, Bobby, Sampang, Honorio, Mortara, Kyle, Bowman, Krista K., Clark, Kevin R., Estevez, Alberto, Xie, Zhiwei, Verschoof, Henry, Grimwood, Michael, Dehnhardt, Christoph, Andrez, Jean–Christophe, Focken, Thilo, Sutherlin, Daniel P., Safina, Brian S., Starovasnik, Melissa A., Ortwine, Daniel F., Franke, Yvonne, Cohen, Charles J., Hackos, David H., Koth, Christopher M., Payandeh, Jian

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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway von Wallin, Jeffrey J, Edgar, Kyle A, Guan, Jane, Berry, Megan, Prior, Wei Wei, Lee, Leslie, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Olivero, Alan G, Sutherlin, Daniel P, O'Brien, Carol, Spoerke, Jill M, Patel, Sonal, Lensun, Letitia, Kassees, Robert, Ross, Leanne, Lackner, Mark R, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S

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Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatme... von Sutherlin, Daniel P, Bao, Linda, Berry, Megan, Castanedo, Georgette, Chuckowree, Irina, Dotson, Jenna, Folks, Adrian, Friedman, Lori, Goldsmith, Richard, Gunzner, Janet, Heffron, Timothy, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Murray, Jeremy, Nonomiya, Jim, Pang, Jodie, Pegg, Niel, Prior, Wei Wei, Rouge, Lionel, Salphati, Laurent, Sampath, Deepak, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wei, BinQing, Wiesmann, Christian, Wu, Ping, Zhu, Bing-Yan, Olivero, Alan

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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain von McKerrall, Steven J, Nguyen, Teresa, Lai, Kwong Wah, Bergeron, Philippe, Deng, Lunbin, DiPasquale, Antonio, Chang, Jae H, Chen, Jun, Chernov-Rogan, Tania, Hackos, David H, Maher, Jonathan, Ortwine, Daniel F, Pang, Jodie, Payandeh, Jian, Proctor, William R, Shields, Shannon D, Vogt, Jennifer, Ji, Pengfei, Liu, Wenfeng, Ballini, Elisa, Schumann, Lilia, Tarozzo, Glauco, Bankar, Girish, Chowdhury, Sultan, Hasan, Abid, Johnson, J. P, Khakh, Kuldip, Lin, Sophia, Cohen, Charles J, Dehnhardt, Christoph M, Safina, Brian S, Sutherlin, Daniel P

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GDC-0449—A potent inhibitor of the hedgehog pathway von Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli

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Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7 von Sun, Shaoyi, Chowdhury, Sultan, Hemeon, Ivan, Hasan, Abid, Wilson, Michael S., Bergeron, Phillipe, Jia, Qi, Zenova, Alla Y., Grimwood, Mike E., Gong, Wei, Decker, Shannon M., Bichler, Paul, Andrez, Jean-Christophe, Focken, Thilo, Ngyuen, Theresa, Zhu, Jiuxiang, White, Andrew D., Bankar, Girish, Howard, Sarah, Chang, Elaine, Khakh, Kuldip, Lin, Sophia, Dean, Richard, Johnson, J.P., Chang, Jae H., Hackos, David H., McKerrall, Steve J., Sellers, Ben, Ortwine, Dan F., Cohen, Charles J., Safina, Brian S., Sutherlin, Daniel P., Dehnhardt, Christoph M.

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Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity von Sun, Shaoyi, Jia, Qi, Zenova, Alla Y, Wilson, Michael S, Chowdhury, Sultan, Focken, Thilo, Li, Jun, Decker, Shannon, Grimwood, Michael E, Andrez, Jean-Christophe, Hemeon, Ivan, Sheng, Tao, Chen, Chien-An, White, Andy, Hackos, David H, Deng, Lunbin, Bankar, Girish, Khakh, Kuldip, Chang, Elaine, Kwan, Rainbow, Lin, Sophia, Nelkenbrecher, Karen, Sellers, Benjamin D, DiPasquale, Antonio G, Chang, Jae, Pang, Jodie, Sojo, Luis, Lindgren, Andrea, Waldbrook, Matthew, Xie, Zhiwei, Young, Clint, Johnson, James P, Robinette, C. Lee, Cohen, Charles J, Safina, Brian S, Sutherlin, Daniel P, Ortwine, Daniel F, Dehnhardt, Christoph M

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Activation and Substrate Specificity of Caspase-14 von Mikolajczyk, Jowita, Scott, Fiona L, Krajewski, Stan, Sutherlin, Daniel P, Salvesen, Guy S

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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa V 1.7 I... von Focken, Thilo, Chowdhury, Sultan, Zenova, Alla, Grimwood, Michael E, Chabot, Christine, Sheng, Tao, Hemeon, Ivan, Decker, Shannon M, Wilson, Michael, Bichler, Paul, Jia, Qi, Sun, Shaoyi, Young, Clint, Lin, Sophia, Goodchild, Samuel J, Shuart, Noah G, Chang, Elaine, Xie, Zhiwei, Li, Bowen, Khakh, Kuldip, Bankar, Girish, Waldbrook, Matthew, Kwan, Rainbow, Nelkenbrecher, Karen, Karimi Tari, Parisa, Chahal, Navjot, Sojo, Luis, Robinette, C Lee, White, Andrew D, Chen, Chien-An, Zhang, Yi, Pang, Jodie, Chang, Jae H, Hackos, David H, Johnson, Jr, J P, Cohen, Charles J, Ortwine, Daniel F, Sutherlin, Daniel P, Dehnhardt, Christoph M, Safina, Brian S

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Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, J.P, Robinette, C. Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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A Unified Model for Apical Caspase Activation von Boatright, Kelly M, Renatus, Martin, Scott, Fiona L, Sperandio, Sabina, Shin, Hwain, Pedersen, Irene M, Ricci, Jean-Ehrland, Edris, Wade A, Sutherlin, Daniel P, Green, Douglas R, Salvesen, Guy S

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A Method for Directed Evolution and Functional Cloning of Enzymes von Pedersen, Henrik, Holder, Swen, Sutherlin, Daniel P., Schwitter, Urs, King, David S., Schultz, Peter G.

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Nav1.7 inhibitors for the treatment of chronic pain von McKerrall, Steven J., Sutherlin, Daniel P.

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Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform von Heffron, Timothy P, Wei, BinQing, Olivero, Alan, Staben, Steven T, Tsui, Vickie, Do, Steven, Dotson, Jennafer, Folkes, Adrian J, Goldsmith, Paul, Goldsmith, Richard, Gunzner, Janet, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Shuttleworth, Stephen, Sutherlin, Daniel P, Wan, Nan Chi, Wang, Shumei, Wiesmann, Christian, Zhu, Bing-Yan

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