EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications von Yasuda, Hiroyuki, MD, Kobayashi, Susumu, MD, Costa, Daniel B, Dr

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Targeting transcription factors in acute myeloid leukemia von Takei, Hisashi, Kobayashi, Susumu S.

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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells von Fujimoto, Yumi, Morita, Tomoko Yamamori, Ohashi, Akihiro, Haeno, Hiroshi, Hakozaki, Yumi, Fujii, Masanori, Kashima, Yukie, Kobayashi, Susumu S., Mukohara, Toru

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Targeting of drug-tolerant persister cells as an approach to counter drug resistance in non-small cell lung cancer von Izumi, Motohiro, Costa, Daniel B., Kobayashi, Susumu S.

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Correlation between Classic Driver Oncogene Mutations in EGFR, ALK, or ROS1 and 22C3–PD-L1 ≥50% Expression in Lung Adenocarcinoma von Rangachari, Deepa, VanderLaan, Paul A., Shea, Meghan, Le, Xiuning, Huberman, Mark S., Kobayashi, Susumu S., Costa, Daniel B.

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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance von Nilsson, Monique B., Yang, Yan, Heeke, Simon, Patel, Sonia A., Poteete, Alissa, Udagawa, Hibiki, Elamin, Yasir Y., Moran, Cesar A., Kashima, Yukie, Arumugam, Thiruvengadam, Yu, Xiaoxing, Ren, Xiaoyang, Diao, Lixia, Shen, Li, Wang, Qi, Zhang, Minying, Robichaux, Jacqulyne P., Shi, Chunhua, Pfeil, Allyson N., Tran, Hai, Gibbons, Don L., Bock, Jason, Wang, Jing, Minna, John D., Kobayashi, Susumu S., Le, Xiuning, Heymach, John V.

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Enantioselective Total Synthesis of (+)-Iso-A82775C, a Proposed Biosynthetic Precursor of Chloropupukeananin von Suzuki, Takahiro, Watanabe, Soichiro, Kobayashi, Susumu, Tanino, Keiji

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Temperature effects on cycling stability of Li plating/stripping on Ta-doped Li7La3Zr2O12 von Yonemoto, Fumihiro, Nishimura, Atsuki, Motoyama, Munekazu, Tsuchimine, Nobuo, Kobayashi, Susumu, Iriyama, Yasutoshi

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Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer von Kashima, Yukie, Shibahara, Daisuke, Suzuki, Ayako, Muto, Kyoko, Kobayashi, Ikei S, Plotnick, David, Udagawa, Hibiki, Izumi, Hiroki, Shibata, Yuji, Tanaka, Kosuke, Fujii, Masanori, Ohashi, Akihiro, Seki, Masahide, Goto, Koichi, Tsuchihara, Katsuya, Suzuki, Yutaka, Kobayashi, Susumu S

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The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer von Izumi, Hiroki, Matsumoto, Shingo, Liu, Jie, Tanaka, Kosuke, Mori, Shunta, Hayashi, Kumiko, Kumagai, Shogo, Shibata, Yuji, Hayashida, Takuma, Watanabe, Kana, Fukuhara, Tatsuro, Ikeda, Takaya, Yoh, Kiyotaka, Kato, Terufumi, Nishino, Kazumi, Nakamura, Atsushi, Nakachi, Ichiro, Kuyama, Shoichi, Furuya, Naoki, Sakakibara-Konishi, Jun, Okamoto, Isamu, Taima, Kageaki, Ebi, Noriyuki, Daga, Haruko, Yamasaki, Akira, Kodani, Masahiro, Udagawa, Hibiki, Kirita, Keisuke, Zenke, Yoshitaka, Nosaki, Kaname, Sugiyama, Eri, Sakai, Tetsuya, Nakai, Tokiko, Ishii, Genichiro, Niho, Seiji, Ohtsu, Atsushi, Kobayashi, Susumu S., Goto, Koichi

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Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells von Takenaka, Tomoya, Nakai, Shinya, Katayama, Miku, Hirano, Mami, Ueno, Natsumi, Noguchi, Kosuke, Takatani-Nakase, Tomoka, Fujii, Ikuo, Kobayashi, Susumu S., Nakase, Ikuhiko

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EGFR Exon 20 Insertion Mutations Display Sensitivity to Hsp90 Inhibition in Preclinical Models and Lung Adenocarcinomas von Jorge, Susan E, Lucena-Araujo, Antonio R, Yasuda, Hiroyuki, Piotrowska, Zofia, Oxnard, Geoffrey R, Rangachari, Deepa, Huberman, Mark S, Sequist, Lecia V, Kobayashi, Susumu S, Costa, Daniel B

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AXL activates YAP through the EGFR–LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma von Okamoto, Kento, Ando, Toshinori, Izumi, Hiroki, Kobayashi, Susumu S., Shintani, Tomoaki, Gutkind, J. Silvio, Yanamoto, Souichi, Miyauchi, Mutsumi, Kajiya, Mikihito

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Mathematical analysis identifies the optimal treatment strategy for epidermal growth factor receptor-mutated non-small cell lung cancer von Yu, Qian, Kobayashi, Susumu S., Haeno, Hiroshi

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EGFR-Mutated Lung Cancers Resistant to Osimertinib through EGFR C797S Respond to First-Generation Reversible EGFR Inhibitors but Eventually Acquire EGFR T790M/C797S in Preclinical... von Rangachari, Deepa, To, Ciric, Shpilsky, Jason E., VanderLaan, Paul A., Kobayashi, Susumu S., Mushajiang, Mierzhati, Lau, Christie J., Paweletz, Cloud P., Oxnard, Geoffrey R., Jänne, Pasi A., Costa, Daniel B.

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In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer von Hirano, Toshiyuki, Yasuda, Hiroyuki, Tani, Tetsuo, Hamamoto, Junko, Oashi, Ayano, Ishioka, Kota, Arai, Daisuke, Nukaga, Shigenari, Miyawaki, Masayoshi, Kawada, Ichiro, Naoki, Katsuhiko, Costa, Daniel B, Kobayashi, Susumu S, Betsuyaku, Tomoko, Soejima, Kenzo

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Biomimetic Total Syntheses of (+)-Chloropupukeananin, (−)-Chloropupukeanolide D, and Chloropestolides von Suzuki, Takahiro, Watanabe, Soichiro, Ikeda, Wataru, Kobayashi, Susumu, Tanino, Keiji

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TIP60 is required for tumorigenesis in non‐small cell lung cancer von Shibahara, Daisuke, Akanuma, Naoki, Kobayashi, Ikei S., Heo, Eunyoung, Ando, Mariko, Fujii, Masanori, Jiang, Feng, Prin, P. Nicholas, Pan, Gilbert, Wong, Kwok‐Kin, Costa, Daniel B., Bararia, Deepak, Tenen, Daniel G., Watanabe, Hideo, Kobayashi, Susumu S.

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CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib von Costa, Daniel B, Kobayashi, Susumu, Pandya, Shuchi S, Yeo, Wee-Lee, Shen, Zhongzhou, Tan, Weiwei, Wilner, Keith D

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TAS2940, a novel brain‐penetrable pan‐ERBB inhibitor, for tumors with HER2 and EGFR aberrations von Oguchi, Kei, Araki, Hikari, Tsuji, Shingo, Nakamura, Masayuki, Miura, Akihiro, Funabashi, Kaoru, Osada, Akiko, Tanaka, Sakiho, Suzuki, Takamasa, Kobayashi, Susumu S., Mizuarai, Shinji

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