Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing von Susswein, Lisa R., Marshall, Megan L., Nusbaum, Rachel, Vogel Postula, Kristen J., Weissman, Scott M., Yackowski, Lauren, Vaccari, Erica M., Bissonnette, Jeffrey, Booker, Jessica K., Cremona, M. Laura, Gibellini, Federica, Murphy, Patricia D., Pineda-Alvarez, Daniel E., Pollevick, Guido D., Xu, Zhixiong, Richard, Gabi, Bale, Sherri, Klein, Rachel T., Hruska, Kathleen S., Chung, Wendy K.

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MSH6 and PMS2 germ-line pathogenic variants implicated in Lynch syndrome are associated with breast cancer von Roberts, Maegan E, Jackson, Sarah A, Susswein, Lisa R, Zeinomar, Nur, Ma, Xinran, Marshall, Megan L, Stettner, Amy R, Milewski, Becky, Xu, Zhixiong, Solomon, Benjamin D, Terry, Mary Beth, Hruska, Kathleen S, Klein, Rachel T, Chung, Wendy K

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Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay von Hu, Chunling, Susswein, Lisa R, Roberts, Maegan E, Yang, Hana, Marshall, Megan L, Hiraki, Susan, Berkofsky-Fessler, Windy, Gupta, Sounak, Shen, Wei, Dunn, Carolyn A, Huang, Huaizhi, Na, Jie, Domchek, Susan M, Yadav, Siddhartha, Monteiro, Alvaro N A, Polley, Eric C, Hart, Steven N, Hruska, Kathleen S, Couch, Fergus J

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Germline pathogenic variants identified in women with ovarian tumors von Carter, Natalie J., Marshall, Megan L., Susswein, Lisa R., Zorn, Kristin K., Hiraki, Susan, Arvai, Kevin J., Torene, Rebecca I., McGill, Anna K., Yackowski, Lauren, Murphy, Patricia D., Xu, Zhixiong, Solomon, Benjamin D., Klein, Rachel T., Hruska, Kathleen S.

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Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C von Hu, Chunling, Nagaraj, Anil Belur, Shimelis, Hermela, Montalban, Gemma, Lee, Kun Y, Huang, Huaizhi, Lumby, Carolyn A, Na, Jie, Susswein, Lisa R, Roberts, Maegan E, Marshall, Megan L, Hiraki, Susan, LaDuca, Holly, Chao, Elizabeth, Yussuf, Amal, Pesaran, Tina, Neuhausen, Susan L, Haiman, Christopher A, Kraft, Peter, Lindstrom, Sara, Palmer, Julie R, Teras, Lauren R, Vachon, Celine M, Yao, Song, Ong, Irene, Nathanson, Katherine L, Weitzel, Jeffrey N, Boddicker, Nicholas, Gnanaolivu, Rohan, Polley, Eric C, Mer, Georges, Cui, Gaofeng, Karam, Rachid, Richardson, Marcy E, Domchek, Susan M, Yadav, Siddhartha, Hruska, Kathleen S, Dolinsky, Jill, Weroha, S John, Hart, Steven N, Simard, Jacques, Masson, Jean Yves, Pang, Yuan-Ping, Couch, Fergus J

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Monoallelic MUTYH pathogenic variants ascertained via multi-gene hereditary cancer panels are not associated with colorectal, endometrial, or breast cancer von Thompson, Amanda Bartenbaker, Sutcliffe, Erin G., Arvai, Kevin, Roberts, Maegan E., Susswein, Lisa R., Marshall, Megan L., Torene, Rebecca, Postula, Kristen J. Vogel, Hruska, Kathleen S., Bai, Shaochun

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Utilization of Online Family History Collection and Hereditary Cancer Risk Assessment Tool [28M] von Gabitzsch, Emily K, Susswein, Lisa R, Klein, Rachel T, Metelski, Deon, Fagbemi, Adebanke F, Solomon, Benjamin D

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Increased Carrier Detection With Expanded Carrier Screening in Multiple Ancestries [7O] von Griswold, Catherine, Yao, Xinxin (Shirley), Susswein, Lisa R, Fagbemi, Adebanke F, Pollevick, Guido D, Klein, Rachel T

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Multi-gene panel testing confirms phenotypic variability in MUTYH-Associated Polyposis von Sutcliffe, Erin G., Bartenbaker Thompson, Amanda, Stettner, Amy R., Marshall, Megan L., Roberts, Maegan E., Susswein, Lisa R., Wang, Ying, Klein, Rachel T., Hruska, Kathleen S., Solomon, Benjamin D.

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Differences in cancer prevalence among CHEK2 carriers identified via multi-gene panel testing von Sutcliffe, Erin G., Stettner, Amy R., Miller, Stacey A., Solomon, Sheila R., Marshall, Megan L., Roberts, Maegan E., Susswein, Lisa R., Arvai, Kevin J., Klein, Rachel T., Murphy, Patricia D., Hruska, Kathleen S.

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Fibroblast testing can inform medical management in individuals with mosaic variants detected on hereditary cancer panels von Sutcliffe, Erin G., Mester, Jessica L., Susswein, Lisa R., Roberts, Maegan E., Marshall, Megan L., Hruska, Kathleen S.

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Ancestry‐specific hereditary cancer panel yields: Moving toward more personalized risk assessment von Roberts, Maegan E., Susswein, Lisa R., Janice Cheng, Wanchun, Carter, Natalie J., Carter, Amber C., Klein, Rachel T., Hruska, Kathleen S., Marshall, Megan L.

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Utility of Expedited Hereditary Cancer Testing in the Surgical Management of Patients with a New Breast Cancer Diagnosis von Theobald, Kristin A., Susswein, Lisa R., Marshall, Megan L., Roberts, Maegan E., Mester, Jessica L., Speyer, Darrow, Williams, Ravin N. W., Knapke, Sara C., Solomon, Sheila R., Murphy, Patricia D., Klein, Rachel T., Hruska, Kathleen S., Solomon, Benjamin D.

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Age-adjusted association of homologous recombination genes with ovarian cancer using clinical exomes as controls von Arvai, Kevin J, Roberts, Maegan E, Torene, Rebecca I, Susswein, Lisa R, Marshall, Megan L, Zhang, Zhancheng, Carter, Natalie J, Yackowski, Lauren, Rinella, Erica S, Klein, Rachel T, Hruska, Kathleen S, Retterer, Kyle

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Increased Uptake of BRCA1/2 Genetic Testing Among African American Women With a Recent Diagnosis of Breast Cancer von SUSSWEIN, Lisa R, SKRZYNIA, Cécile, LANGE, Leslie A, BOOKER, Jessica K, GRAHAM, Mark L, EVANS, James P

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Racial Differences in Enrolment in a Cancer Genetics Registry von MOORMAN, Patricia G, SKINNER, Celette Sugg, EVANS, James P, NEWMAN, Beth, SORENSON, James R, CALINGAERT, Brian, SUSSWEIN, Lisa, CRANKSHAW, T. Sydnee, HOYO, Cathrine, SCHILDKRAUT, Joellen M

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Germline Genetic Testing After Cancer Diagnosis von Kurian, Allison W, Abrahamse, Paul, Furgal, Allison, Ward, Kevin C, Hamilton, Ann S, Hodan, Rachel, Tocco, Rachel, Liu, Lihua, Berek, Jonathan S, Hoang, Lily, Yussuf, Amal, Susswein, Lisa, Esplin, Edward D, Slavin, Thomas P, Gomez, Scarlett L, Hofer, Timothy P, Katz, Steven J

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899 YALE CRITERIA FOR GENETIC TESTING IN CASES OF SUSPECTED HEREDITARY DIFFUSE GASTRIC CANCER (HDGC) ARE MORE SENSITIVE THAN IGCLC AND ERN GENTURIS CRITERIA IN A LARGE AMERICAN COH... von Lerner, Benjamin A., Giner-Calabuig, Mar, Carraway, Cassidy, Richardson, Marcy E., Krahn, Karl, Susswein, Lisa, Heald, Brandie, Karam, Rachid, Xicola, Rosa M., Llor, Xavier

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Ethical issues in identifying and recruiting participants for familial genetic research von Beskow, Laura M., Botkin, Jeffrey R., Daly, Mary, Juengst, Eric T., Lehmann, Lisa Soleymani, Merz, Jon F., Pentz, Rebecca, Press, Nancy A., Ross, Lainie Friedman, Sugarman, Jeremy, Susswein, Lisa R., Terry, Sharon F., Austin, Melissa A., Burke, Wylie

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OP014: Fibroblast testing can inform medical management in individuals with mosaic variants detected on hereditary cancer panels von Sutcliffe, Erin, Mester, Jessica, Susswein, Lisa, Roberts, Maegan, Marshall, Megan, Hruska, Kathleen

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