Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors von Stokes, Michael E, Surman, Matthew D, Calvo, Veronica, Surguladze, David, Li, An-Hu, Gasparek, Jennifer, Betzenhauser, Matthew, Zhu, Guangyu, Du, Hongwen, Rigby, Alan C, Mulvihill, Mark J

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders von Gurney, Mark E, Nugent, Richard A, Mo, Xuesheng, Sindac, Janice A, Hagen, Timothy J, Fox, David, O’Donnell, James M, Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Groppi, Vincent E, Bailie, Marc, White, Ronald E, Romero, Donna L, Vellekoop, A. Samuel, Walker, Joel R, Surman, Matthew D, Zhu, Lei, Campbell, Robert F

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Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors von Calvo, Veronica, Surguladze, David, Li, An-Hu, Surman, Matthew D., Malibhatla, Srikanth, Bandaru, Madhavarao, Jonnalagadda, Suresh Krishna, Adarasandi, Ravi, Velmala, Madhusudhan, Singireddi, Durga Rama Prasad, Velpuri, Mahendar, Nareddy, Bhaskar Reddy, Sastry, Visweswara, Mandati, Chiranjeevi, Guguloth, Rambabu, Siddiqui, Shapi, Patil, Basanagoud S., Chad, Elena, Wolfley, Jennifer, Gasparek, Jennifer, Feldman, Kirsten, Betzenhauser, Matthew, Wiens, Brent, Koszelak-Rosenblum, Mary, Zhu, Guangyu, Du, Hongwen, Rigby, Alan C., Mulvihill, Mark J.

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From preclinical to clinical development: The example of a novel treatment for obesity von Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Surman, Matthew D

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Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity von Hadden, Mark, Deering, Dustin M., Henderson, Alan J., Surman, Matthew D., Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.

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Synthesis and SAR of vinca alkaloid analogues von Voss, Matthew E., Ralph, Jeffery M., Xie, Dejian, Manning, David D., Chen, Xinchao, Frank, Anthony J., Leyhane, Andrew J., Liu, Lei, Stevens, Jason M., Budde, Cheryl, Surman, Matthew D., Friedrich, Thomas, Peace, Denise, Scott, Ian L., Wolf, Mark, Johnson, Randall

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5-(Pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists von Surman, Matthew D., Freeman, Emily E., Grabowski, James F., Hadden, Mark, Henderson, Alan J., Jiang, Guowei, Jiang, Xiaowu (May), Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.

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Stereo- and Regioselectivity of Pd0/InI-Mediated Allylic Additions to Aldehydes and Ketones. In Situ Generation of Allylindium(III) Intermediates from N-Acylnitroso Diels−Alder Cyc... von Lee, Wenlin, Kim, Kyung-Hee, Surman, Matthew D, Miller, Marvin J

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Tetrahydrocarboline analogs as MCH-1 antagonists von Henderson, Alan J., Deering, Dustin, Grabowski, James F., Hadden, Mark, Jiang, Xiaowu, Khmelnitsky, Yuri, Luche, Michele, Surman, Matthew D., Cheetham, Sharon, Vickers, Steven, Viggers, Jean, Guzzo, Peter R.

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Stereo- and regioselectivity of Pd(0)/InI-mediated allylic additions to aldehydes and ketones. In situ generation of allylindium(III) intermediates from N-acylnitroso Diels-Alder c... von Lee, Wenlin, Kim, Kyung-Hee, Surman, Matthew D, Miller, Marvin J

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Regio- and Stereoselective Ring Openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene Systems with Copper Catalyst-Modified Grignard Reagents:  Application to the Synthesis of an Inhibit... von Surman, Matthew D, Mulvihill, Mark J, Miller, Marvin J

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Preparation of Sitagliptin M2 and M5 metabolites and degradation impurities through a stereocontrolled amidine reduction von Surman, Matthew D., Chen, Ping, Avramovitch, Bianca, Haber, Kathy, Buckle, Ronald N., Gazal, Sharon

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Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels−Alder Cycloadducts von Surman, Matthew D, Mulvihill, Mark J, Miller, Marvin J

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Synthesis of a Conformationally Restricted Substrate Analogue of Siderophore Biosynthetases von Surman, Matthew D, Miller, Marvin J

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Novel α-substituted β-amino diesters from acylnitroso-derived hetero-Diels–Alder cycloadducts von Surman, Matthew D, Mulvihill, Mark J, Miller, Marvin J

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Regio- and Stereoselective Fe(III)- and Pd(0)-Mediated Ring Openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene Systems von Mulvihill, Mark J, Surman, Matthew D, Miller, Marvin J

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Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing a nti- or s yn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts von Surman, Matthew D, Miller, Marvin J

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Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing anti- or syn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts von SURMAN, Matthew D., MILLER, Marvin J.

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The synthesis and SAR of novel diarylsulfone 11b-HSD1 inhibitors von Hadden, Mark, Deering, Dustin M, Henderson, Alan J, Surman, Matthew D, Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R

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Stereo- and Regioselectivity of Pd 0 /InI-Mediated Allylic Additions to Aldehydes and Ketones. In Situ Generation of Allylindium(III) Intermediates from N -Acylnitroso Diels−Alder... von Lee, Wenlin, Kim, Kyung-Hee, Surman, Matthew D., Miller, Marvin J.

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