Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor von Surleraux, Dominique L. N. G, Tahri, Abdellah, Verschueren, Wim G, Pille, Geert M. E, de Kock, Herman A, Jonckers, Tim H. M, Peeters, Anik, De Meyer, Sandra, Azijn, Hilde, Pauwels, Rudi, de Bethune, Marie-Pierre, King, Nancy M, Prabu-Jeyabalan, Moses, Schiffer, Celia A, Wigerinck, Piet B. T. P

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TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates von DE MEYER, Sandra, AZIJN, Hilde, SURLERAUX, Dominique, JOCHMANS, Dirk, TAHRI, Abdellah, PAUWELS, Rudi, WIGERINCK, Piet, DE BETHUNE, Marie-Pierre

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Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors of HIV-1 Integrase von Verschueren, Wim G, Dierynck, Inge, Amssoms, Katie I. E, Hu, Lili, Boonants, Paul M. J. G, Pille, Geert M. E, Daeyaert, Frits F. D, Hertogs, Kurt, Surleraux, Dominique L. N. G, Wigerinck, Piet B. T. P

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Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC43... von Raboisson, Pierre, de Kock, Herman, Rosenquist, Åsa, Nilsson, Magnus, Salvador-Oden, Lourdes, Lin, Tse-I, Roue, Natalie, Ivanov, Vladimir, Wähling, Horst, Wickström, Kristina, Hamelink, Elizabeth, Edlund, Michael, Vrang, Lotta, Vendeville, Sandrine, Van de Vreken, Wim, McGowan, David, Tahri, Abdellah, Hu, Lili, Boutton, Carlo, Lenz, Oliver, Delouvroy, Frederic, Pille, Geert, Surleraux, Dominique, Wigerinck, Piet, Samuelsson, Bertil, Simmen, Kenneth

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Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus von Surleraux, Dominique L. N. G, de Kock, Herman A, Verschueren, Wim G, Pille, Geert M. E, Maes, Louis J. R, Peeters, Anik, Vendeville, Sandrine, De Meyer, Sandra, Azijn, Hilde, Pauwels, Rudi, de Bethune, Marie-Pierre, King, Nancy M, Prabu-Jeyabalan, Moses, Schiffer, Celia A, Wigerinck, Piet B. T. P

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Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease von Parsy, Christophe, Alexandre, François-René, Brandt, Guillaume, Caillet, Catherine, Cappelle, Sylvie, Chaves, Dominique, Convard, Thierry, Derock, Michel, Gloux, Damien, Griffon, Yann, Lallos, Lisa, Leroy, Frédéric, Liuzzi, Michel, Loi, Anna-Giulia, Moulat, Laure, Musiu, Chiara, Rahali, Houcine, Roques, Virginie, Seifer, Maria, Standring, David, Surleraux, Dominique

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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors von PAUWELS, Frederik, MOSTMANS, Wendy, SIMMEN, Kenneth A, QUIRYNEN, Ludo M. M, VAN DER HELM, Liesbet, BOUTTON, Carlo W, RUEFF, Anne-Stéphanie, CLEIREN, Erna, RABOISSON, Pierre, SURLERAUX, Dominique, NYANGUILE, Origène

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Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors von Raboisson, Pierre, Lenz, Oliver, Lin, Tse-I, Surleraux, Dominique, Chakravarty, Sarvajit, Scholliers, Annick, Vermeiren, Katrien, Delouvroy, Frederic, Verbinnen, Thierry, Simmen, Kenneth

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Development of Novel Highly Specific FLT3 Targeted Inhibitors for Combination or Sequential Therapy of Acute Myeloid Leukemia von Sabir, Misbah, Hellesoy, Monica, Kivioja, Jarno, Engen, Caroline, Amiable, Claire, Popa, Mihaela, Guillon, Remi, Bruserud, Øystein, Heckman, Caroline A, McCormack, Emmet, Surleraux, Dominique, Gjertsen, Bjørn Tore

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The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitor... von Alexandre, François-René, Badaroux, Eric, Bilello, John P., Bot, Stéphanie, Bouisset, Tony, Brandt, Guillaume, Cappelle, Sylvie, Chapron, Christopher, Chaves, Dominique, Convard, Thierry, Counor, Clément, Da Costa, Daniel, Dukhan, David, Gay, Marion, Gosselin, Gilles, Griffon, Jean-François, Gupta, Kusum, Hernandez-Santiago, Brenda, La Colla, Massimiliano, Lioure, Marie-Pierre, Milhau, Julien, Paparin, Jean-Laurent, Peyronnet, Jérôme, Parsy, Christophe, Pierra Rouvière, Claire, Rahali, Houcine, Rahali, Rachid, Salanson, Aurélien, Seifer, Maria, Serra, Ilaria, Standring, David, Surleraux, Dominique, Dousson, Cyril B.

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Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320 von Parsy, Christophe C., Alexandre, François-René, Bidau, Valérie, Bonnaterre, Florence, Brandt, Guillaume, Caillet, Catherine, Cappelle, Sylvie, Chaves, Dominique, Convard, Thierry, Derock, Michel, Gloux, Damien, Griffon, Yann, Lallos, Lisa B., Leroy, Frederic, Liuzzi, Michel, Loi, Anna-Giulia, Moulat, Laure, Chiara, Musiu, Rahali, Houcine, Roques, Virginie, Rosinovsky, Elodie, Savin, Simon, Seifer, Maria, Standring, David, Surleraux, Dominique

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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor von Paparin, Jean-Laurent, Amador, Agnès, Badaroux, Eric, Bot, Stéphanie, Caillet, Catherine, Convard, Thierry, Da Costa, Daniel, Dukhan, David, Griffe, Ludovic, Griffon, Jean-François, LaColla, Massimiliano, Leroy, Frédéric, Liuzzi, Michel, Giulia Loi, Anna, McCarville, Joe, Mascia, Valeria, Milhau, Julien, Onidi, Loredana, Pierra, Claire, Rahali, Rachid, Rosinosky, Elodie, Sais, Efisio, Seifer, Maria, Surleraux, Dominique, Standring, David, Dousson, Cyril B.

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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease von Alexandre, François-René, Brandt, Guillaume, Caillet, Catherine, Chaves, Dominique, Convard, Thierry, Derock, Michel, Gloux, Damien, Griffon, Yann, Lallos, Lisa, Leroy, Frédéric, Liuzzi, Michel, Loi, Anna-Giulia, Moulat, Laure, Musiu, Chiara, Parsy, Christophe, Rahali, Houcine, Roques, Virginie, Seifer, Maria, Standring, David, Surleraux, Dominique

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Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase von Pierra Rouvière, Claire, Amador, Agnès, Badaroux, Eric, Convard, Thierry, Da Costa, Daniel, Dukhan, David, Griffe, Ludovic, Griffon, Jean-François, LaColla, Massimiliano, Leroy, Frédéric, Liuzzi, Michel, Loi, Anna Giulia, McCarville, Joe, Mascia, Valeria, Milhau, Julien, Onidi, Loredana, Paparin, Jean-Laurent, Rahali, Rachid, Sais, Efisio, Seifer, Maria, Surleraux, Dominique, Standring, David, Dousson, Cyril

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Corrigendum to “Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues” [Tetrahedron Lett. 55 (2014) 6328–6330] von Dayde, Bénédicte, Pierra, Claire, Gosselin, Gilles, Surleraux, Dominique, Da Costa, Daniel, Ilagouma, Amadou Tidjani, Volle, Jean-Noël, Virieux, David, Pirat, Jean-Luc

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Synthesis of Unnatural Phosphonosugar Analogues von Dayde, Bénédicte, Pierra, Claire, Gosselin, Gilles, Surleraux, Dominique, Ilagouma, Amadou Tidjani, Laborde, Coralie, Volle, Jean-Noel, Virieux, David, Pirat, Jean-Luc

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NUCLEOSIDE KINASE INHIBITORS von SURLERAUX, Dominique

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Corrigendum to “Synthesis of unnatural 2- and 3-deoxyfuranose analogues” [Tetrahedron Lett. 55 (2014) 3706–3708] von Dayde, Bénédicte, Pierra, Claire, Gosselin, Gilles, Surleraux, Dominique, Da Costa, Daniel, Ilagouma, Amadou Tidjani, Van der Lee, Arie, Volle, Jean-Noël, Virieux, David, Pirat, Jean-Luc

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Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues von Dayde, Bénédicte, Pierra, Claire, Gosselin, Gilles, Surleraux, Dominique, Ilagouma, Amadou Tidjani, Volle, Jean-Noël, Virieux, David, Pirat, Jean-Luc

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Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor von Sizun, Gwenaëlle, Pierra, Claire, Peyronnet, Jérôme, Badaroux, Eric, Rabeson, Céline, Benzaria-Prad, Samira, Surleraux, Dominique, Loi, Anna Giulia, Musiu, Chiara, Liuzzi, Michel, Seifer, Maria, Standring, David, Sommadossi, Jean-Pierre, Gosselin, Gilles

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