Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 von Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Van Phung, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Xu Wu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.

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Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers von Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Zhang, Bailin, He, Timothy, Gao, Qiang, Gee, Patricia, Simard, Daniel, Castaldi, M. Paola, Tomlinson, Ronald, Reiling, Stephan, Barrague, Matthieu, Newcombe, Richard, Cao, Hui, Wang, Yanjun, Sun, Fangxian, Murtie, Joshua, Munson, Mark, Yang, Eric, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Cheng, Hong, Adrian, Francisco, Winter, Christopher, Licht, Stuart, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron

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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors von Ding, Qiang, Jahnke, Wolfgang, Adrián, Francisco J, Guo, Gui-Rong, Warmuth, Markus, Deng, Xianming, Grzesiek, Stephan, Bursulaya, Badry, Gray, Nathanael S, Okram, Barun, Tuntland, Tove, Azam, Mohammad, Li, Allen G, Powers, John, Dierks, Christine, Strauss, André, Engen, John R, Cowan-Jacob, Sandra W, Wojciechowski, Amy, Liu, Yi, Fendrich, Gabriele, Iacob, Roxana E, Sim, Taebo, Sun, Fangxian, Vajpai, Navratna, Zhang, Jianming, Liu, Guoxun, Daley, George Q, Manley, Paul W, Choi, Yongmun

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Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents von Griebel, Guy, Pichat, Philippe, Beeské, Sandra, Leroy, Thibaud, Redon, Nicolas, Jacquet, Agnès, Françon, Dominique, Bert, Lionel, Even, Luc, Lopez-Grancha, Mati, Tolstykh, Tatiana, Sun, Fangxian, Yu, Qunyan, Brittain, Scott, Arlt, Heike, He, Timothy, Zhang, Bailin, Wiederschain, Dmitri, Bertrand, Thomas, Houtmann, Jacques, Rak, Alexey, Vallée, François, Michot, Nadine, Augé, Franck, Menet, Véronique, Bergis, Olivier E., George, Pascal, Avenet, Patrick, Mikol, Vincent, Didier, Michel, Escoubet, Johanna

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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK von Galkin, Anna V, Melnick, Jonathan S, Kim, Sungjoon, Hood, Tami L, Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G, Gray, Nathanael S, Warmuth, Markus

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist von Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion

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Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells von Wagenaar, Timothy R, Tolstykh, Tatiana, Shi, Chaomei, Jiang, Lan, Zhang, JingXin, Li, Zhifang, Yu, Qunyan, Qu, Hui, Sun, Fangxian, Cao, Hui, Pollard, Jack, Dai, Shujia, Gao, Qiang, Zhang, Bailin, Arlt, Heike, Cindhuchao, May, Hoffmann, Dietmar, Light, Madelyn, Jensen, Karin, Hopke, Joern, Newcombe, Richard, Garcia-Echeverria, Carlos, Winter, Christopher, Zabludoff, Sonya, Wiederschain, Dmitri

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An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy von Bernardo, Marie, Tolstykh, Tatiana, Zhang, Yu-an, Bangari, Dinesh S., Cao, Hui, Heyl, Kerstin A., Lee, Joon Sang, Malkova, Natalia V., Malley, Katie, Marquez, Eladio, Pollard, Jack, Qu, Hui, Roberts, Errin, Ryan, Sue, Singh, Kuldeep, Sun, Fangxian, Wang, Emma, Bahjat, Keith, Wiederschain, Dmitri, Wagenaar, Timothy R.

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In vivo selection for metastasis promoting genes in the mouse von Gumireddy, Kiranmai, Sun, Fangxian, Klein-Szanto, Andres J, Gibbins, Jonathan M, Gimotty, Phyllis A, Saunders, Aleister J, Schultz, Peter G, Huang, Qihong

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Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms von Huang, Shih-Min A., Wang, Anlai, Greco, Rita, Li, Zhifang, Sun, Fangxian, Barberis, Claude, Tabart, Michel, Patel, Vinod, Schio, Laurent, Hurley, Raelene, Chen, Bo, Cheng, Hong, Lengauer, Christoph, Pollard, Jack, Watters, James, Garcia-Echeverria, Carlos, Wiederschain, Dmitri, Adrian, Francisco, Zhang, JingXin

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Abstract 2712: Donor selection strategies to optimize humanized mouse models for the evaluation of T cell engagers von Cheng, Liqing, Chen, Jane, Yu, Qunyan, Malkova, Natalia, Cortez-Retamozo, Virna F., Sun, Fangxian, Sidhu, Sukhvinder

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SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models von Shomali, Maysoun, Cheng, Jane, Sun, Fangxian, Koundinya, Malvika, Guo, Zhuyan, Hebert, Andrew T, McManus, Jessica, Levit, Mikhail N, Hoffmann, Dietmar, Courjaud, Albane, Arrebola, Rosalia, Cao, Hui, Pollard, Jack, Lee, Joon Sang, Besret, Laurent, Caron, Anne, Bangari, Dinesh S, Abecassis, Pierre-Yves, Schio, Laurent, El-Ahmad, Youssef, Halley, Frank, Tabart, Michel, Certal, Victor, Thompson, Fabienne, McCort, Gary, Filoche-Rommé, Bruno, Cheng, Hong, Garcia-Echeverria, Carlos, Debussche, Laurent, Bouaboula, Monsif

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Abstract P4-02-08: Amcenestrant in combination with CDK4/6 inhibitor palbociclib demonstrates synergistic anti-tumor activity in ER+ endocrine-resistant breast cancer xenograft mod... von Shomali, Maysoun, Guo, Zhuyan, Cheng, Jane, Sullivan, Amy, El-Ahmad, Youssef, Sun, Fangxian, Sidhu, Sukhvinder, Lee, Joon Sang, Cai, Hui, Pollard, Jack, Debussche, Laurent, Soria, Chris, Bouaboula, Monsif

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Discovery of 6‑(2,4-Dichlorophenyl)-5-[4-[(3S)‑1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro‑7H‑benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Es... von El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent

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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7 H -benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selectiv... von El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent

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Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation von Wu, Lan, Seung, Edward, Xu, Ling, Rao, Ercole, Lord, Dana M., Wei, Ronnie R., Cortez-Retamozo, Virna, Ospina, Beatriz, Posternak, Valeriya, Ulinski, Gregory, Piepenhagen, Peter, Francesconi, Elisa, El-Murr, Nizar, Beil, Christian, Kirby, Patrick, Li, Aiqun, Fretland, Jennifer, Vicente, Rita, Deng, Gejing, Dabdoubi, Tarik, Cameron, Beatrice, Bertrand, Thomas, Ferrari, Paul, Pouzieux, Stéphanie, Lemoine, Cendrine, Prades, Catherine, Park, Anna, Qiu, Huawei, Song, Zhili, Zhang, Bailin, Sun, Fangxian, Chiron, Marielle, Rao, Srinivas, Radošević, Katarina, Yang, Zhi-yong, Nabel, Gary J.

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Abstract PS17-16: Sar439859, a novel selective estrogen receptor degrader (serd), demonstrates effective and broad antitumor activity in wild-type and mutant er-positive breast can... von Shomali, Maysoun, Sun, Fangxian, Levit, Mikhail, Pollard, Jack, Lee, Joon Sang, Schio, Laurent, El-Ahmad, Youssef, Soria, Chris, Cohen, Patrick, Debussche, Laurent, Bouaboula, Monsif

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Abstract 3452: Pre-clinical development of next generation selective estrogen receptor degrader - SAR439859 von Sun, Fangxian, Cheng, Jane, Sullivan, Amy, Malkova, Natalia, Shomali, Maysoun, McManus, Jesseca, Levit, Mikhail, Bangari, Dinesh, El-Ahmad, Youssef, Sidhu, Sukhvinder, Debussche, Laurent, Bouaboula, Monsif

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Abstract 1590: An experimental tumor model resistant to anti-PD-1 is sensitive to local mRNA immunotherapy von Bernardo, Marie, Tolstykh, Tatiana, Zhang, Yu-an, Bangari, Dinesh S., Cao, Hui, Heyl, Kerstin A., Lee, Joon Sang, Malkova, Natalia, Pollard, Jack, Qu, Hui, Sun, Fangxian, Wiederschain, Dmitri, Wagenaar, Timothy R.

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Abstract 739: Preclinical and clinical activity of SAR439859, Amcenestrant, a next generation SERD von Shomali, Maysoun, Sun, Fangxian, Besret, Laurent, Caron, Anne, Lee, Joon Sang, El-Ahmed, Youssef, Schio, Laurent, Pollard, Jack, Pelekanou, Vasiliki, Cohen, Patrick, Celanovic, Marina, Herold, Christina, Soria, Chris, Debussche, Laurent, Bouaboula, Monsif

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