Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions von Ayyar, Vivaswath S., Sukumaran, Siddharth

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An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia von Leong, Steven R., Sukumaran, Siddharth, Hristopoulos, Maria, Totpal, Klara, Stainton, Shannon, Lu, Elizabeth, Wong, Alfred, Tam, Lucinda, Newman, Robert, Vuillemenot, Brian R., Ellerman, Diego, Gu, Chen, Mathieu, Mary, Dennis, Mark S., Nguyen, Allen, Zheng, Bing, Zhang, Crystal, Lee, Genee, Chu, Yu-Waye, Prell, Rodney A., Lin, Kedan, Laing, Steven T., Polson, Andrew G.

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Exposing the molecular heterogeneity of glycosylated biotherapeutics von Schachner, Luis F., Mullen, Christopher, Phung, Wilson, Hinkle, Joshua D., Beardsley, Michelle Irwin, Bentley, Tracy, Day, Peter, Tsai, Christina, Sukumaran, Siddharth, Baginski, Tomasz, DiCara, Danielle, Agard, Nicholas J., Masureel, Matthieu, Gober, Joshua, ElSohly, Adel M., Melani, Rafael, Syka, John E. P., Huguet, Romain, Marty, Michael T., Sandoval, Wendy

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Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action von Sukumaran, Siddharth, Almon, Richard R., DuBois, Debra C., Jusko, William J.

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Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action von Sukumaran, Siddharth, Jusko, William J, Dubois, Debra C, Almon, Richard R

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A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma von Rymut, Sharon M., Henderson, Lindsay M., Poon, Victor, Staton, Tracy L., Cai, Fang, Sukumaran, Siddharth, Rhee, Horace, Owen, Ryan, Ramanujan, Saroja, Yoshida, Kenta

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Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial von Rymut, Sharon M., Sukumaran, Siddharth, Sperinde, Gizette, Bremer, Meire, Galanter, Joshua, Yoshida, Kenta, Smith, Jordan, Banerjee, Prajna, Sverkos, Viyia, Cai, Fang, Steffen, Verena, Henderson, Lindsay M., Rhee, Horace, Belloni, Paula N., Lin, Joseph H., Staton, Tracy L.

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Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism von Gadkar, Kapil, Feigelman, Justin, Sukumaran, Siddharth, Rodrigo, Manoj C., Staton, Tracy, Cai, Fang, Bauer, Rebecca N., Choy, David F., Stokes, Cynthia L., Scheerens, Heleen, Ramanujan, Saroja

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Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats von Xue, Bai, Sukumaran, Siddharth, Nie, Jing, Jusko, William J, Dubois, Debra C, Almon, Richard R

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Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent... von Yadav, Rajbharan, Sukumaran, Siddharth, Zabka, Tanja S, Li, Jinze, Oldendorp, Amy, Morrow, Gary, Reyes, Arthur, Cheu, Melissa, Li, Jessica, Wallin, Jeffrey J, Tsai, Siao, Sun, Laura, Wang, Peiyin, Ellerman, Diego, Spiess, Christoph, Polson, Andy, Stefanich, Eric G, Kamath, Amrita V, Ovacik, Meric A

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Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats von Nie, Jing, Xue, Bai, Sukumaran, Siddharth, Jusko, William J., DuBois, Debra C., Almon, Richard R.

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Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology von Sukumaran, Siddharth, Xue, Bai, Jusko, William J, Dubois, Debra C, Almon, Richard R

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Meta-modeling of methylprednisolone effects on glucose regulation in rats von Fang, Jing, Sukumaran, Siddharth, Dubois, Debra C, Almon, Richard R, Jusko, William J

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Circadian signatures in rat liver: from gene expression to pathways von Ovacik, Meric A, Sukumaran, Siddharth, Almon, Richard R, DuBois, Debra C, Jusko, William J, Androulakis, Ioannis P

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Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing von Li, Ji, Stagg, Nicola J., Johnston, Jennifer, Harris, Michael J., Menzies, Sam A., DiCara, Danielle, Clark, Vanessa, Hristopoulos, Maria, Cook, Ryan, Slaga, Dionysos, Nakamura, Rin, McCarty, Luke, Sukumaran, Siddharth, Luis, Elizabeth, Ye, Zhengmao, Wu, Thomas D., Sumiyoshi, Teiko, Danilenko, Dimitry, Lee, Genee Y., Totpal, Klara, Ellerman, Diego, Hötzel, Isidro, James, John R., Junttila, Teemu T.

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Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration von Nguyen, Tung T., Almon, Richard R., DuBois, Debra C., Sukumaran, Siddharth, Jusko, William J., Androulakis, loannis P.

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Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases von Stefanich, Eric G., Rae, Julie, Sukumaran, Siddharth, Lutman, Jeff, Lekkerkerker, Annemarie, Ouyang, Wenjun, Wang, Xiaoting, Lee, Donna, Danilenko, Dimitry M., Diehl, Lauri, Loyet, Kelly M., Herman, Ann

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Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and Pharmacodynamics of Efmarodocokin Alfa, a Varia... von Tao, Xun, Sukumaran, Siddharth, Sperinde, Gizette, Liu, Chang, Beardsley, Michelle Irwin, Day, Peter, Kalo, Matt, Ayewoh, Ebehiremen, Cai, Hao, Wang, Yehong, Jun, Inyoung, Hirst, Kyle, Nguyen, Van, Chung, Shan, Lee, Donna, Lekkerkerker, Annemarie, Stefanich, Eric

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A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab‐Treated non‐small Cell Lung Cancer Patients von Netterberg, Ida, Li, Chi‐Chung, Molinero, Luciana, Budha, Nageshwar, Sukumaran, Siddharth, Stroh, Mark, Jonsson, E. Niclas, Friberg, Lena E.

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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