The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice von Okuda, Michiaki, Fujita, Yuki, Sugimoto, Hachiro

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The new approach in development of anti-Alzheimer's disease drugs via the cholinergic hypothesis von Sugimoto, Hachiro

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Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation von Okuda, Michiaki, Fujita, Yuki, Takada-Takatori, Yuki, Sugimoto, Hachiro, Urakami, Katsuya

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Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features von Shimmyo, Yoshiari, Kihara, Takeshi, Akaike, Akinori, Niidome, Tetsuhiro, Sugimoto, Hachiro

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Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Su... von Mizuno, Keita, Kume, Toshiaki, Muto, Chie, Takada-Takatori, Yuki, Izumi, Yasuhiko, Sugimoto, Hachiro, Akaike, Akinori

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Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cas... von Takada-Takatori, Yuki, Kume, Toshiaki, Sugimoto, Mitsuhiro, Katsuki, Hiroshi, Sugimoto, Hachiro, Akaike, Akinori

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Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins von Tanaka, Naoki, Okuda, Michiaki, Nishigaki, Tatsutoshi, Tsuchiya, Nobuhiko, Kobayashi, Yukako, Uemura, Takuya, Kumo, Sayaka, Sugimoto, Hachiro, Miyata, Seiji, Waku, Tomonori

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LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11 von Sagane, Koji, Ishihama, Yasushi, Sugimoto, Hachiro

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Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: Involvement of direct inhibition of caspase-3 von Shimmyo, Yoshiari, Kihara, Takeshi, Akaike, Akinori, Niidome, Tetsuhiro, Sugimoto, Hachiro

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Long-Term Ultra-High Hydrostatic Pressurized Brown Rice Intake Prevents Bone Mineral Density Decline in Elderly Japanese Individuals von MATSUZAKI, Kentaro, YANO, Shozo, SUMIYOSHI, Eri, SHIDO, Osamu, KATSUBE, Takuya, TABATA, Mitsumasa, OKUDA, Michiaki, SUGIMOTO, Hachiro, YOSHINO, Katsumi, HASHIMOTO, Michio

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Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells von Sampetrean, Oltea, Saga, Isako, Nakanishi, Masaya, Sugihara, Eiji, Fukaya, Raita, Onishi, Nobuyuki, Osuka, Satoru, Akahata, Masaki, Kai, Kazuharu, Sugimoto, Hachiro, Hirao, Atsushi, Saya, Hideyuki

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PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo von Okuda, Michiaki, Hijikuro, Ichiro, Fujita, Yuki, Wu, Xiaofeng, Nakayama, Shinichi, Sakata, Yoko, Noguchi, Yuji, Ogo, Makoto, Akasofu, Shigeru, Ito, Yoshimasa, Soeda, Yoshiyuki, Tsuchiya, Nobuhiko, Tanaka, Naoki, Takahashi, Takashi, Sugimoto, Hachiro

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Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation von Urano, Yasuomi, Takahachi, Mina, Higashiura, Ryo, Fujiwara, Hitomi, Funamoto, Satoru, Imai, So, Futai, Eugene, Okuda, Michiaki, Sugimoto, Hachiro, Noguchi, Noriko

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Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis) von Izumi, Yasuhiko, Matsumura, Atsuko, Wakita, Seiko, Akagi, Ken-ichi, Fukuda, Hiroyuki, Kume, Toshiaki, Irie, Kazuhiro, Takada-Takatori, Yuki, Sugimoto, Hachiro, Hashimoto, Tadashi, Akaike, Akinori

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Influence of Ultra-High Hydrostatic Pressurizing Brown Rice on Cognitive Functions and Mental Health of Elderly Japanese Individuals: A 2-Year Randomized and Controlled Trial von KURODA, Yoko, MATSUZAKI, Kentaro, WAKATSUKI, Harumi, SHIDO, Osamu, HARAUMA, Akiko, MORIGUCHI, Toru, SUGIMOTO, Hachiro, YAMAGUCHI, Shuhei, YOSHINO, Katsumi, HASHIMOTO, Michio

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Amyloid precursor protein promotes endoplasmic reticulum stress‐induced cell death via C/EBP homologous protein‐mediated pathway von Takahashi, Keita, Niidome, Tetsuhiro, Akaike, Akinori, Kihara, Takeshi, Sugimoto, Hachiro

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Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice von Taniuchi, Nobuhiko, Niidome, Tetsuhiro, Goto, Yasuaki, Akaike, Akinori, Kihara, Takeshi, Sugimoto, Hachiro

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Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene von Wang, Pi-Lin, Niidome, Tetsuhiro, Akaike, Akinori, Kihara, Takeshi, Sugimoto, Hachiro

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Distinct mechanisms underlie distinct polyphenol-induced neuroprotection von Yazawa, Keiko, Kihara, Takeshi, Shen, Huilian, Shimmyo, Yoshiari, Niidome, Tetsuhiro, Sugimoto, Hachiro

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Characterization of sequential N-cadherin cleavage by ADAM10 and PS1 von Uemura, Kengo, Kihara, Takeshi, Kuzuya, Akira, Okawa, Katsuya, Nishimoto, Takaaki, Ninomiya, Haruaki, Sugimoto, Hachiro, Kinoshita, Ayae, Shimohama, Shun

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