Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth von Hitosugi, Taro, Zhou, Lu, Elf, Shannon, Fan, Jun, Kang, Hee-Bum, Seo, Jae Ho, Shan, Changliang, Dai, Qing, Zhang, Liang, Xie, Jianxin, Gu, Ting-Lei, Jin, Peng, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Sudderth, Jessica A., DeBerardinis, Ralph J., Luan, Chi-Hao, Chen, Georgia Z., Muller, Susan, Shin, Dong M., Owonikoko, Taofeek K., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Ye, Keqiang, Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

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NRF2 regulates serine biosynthesis in non–small cell lung cancer von DeNicola, Gina M, Chen, Pei-Hsuan, Mullarky, Edouard, Sudderth, Jessica A, Hu, Zeping, Wu, David, Tang, Hao, Xie, Yang, Asara, John M, Huffman, Kenneth E, Wistuba, Ignacio I, Minna, John D, DeBerardinis, Ralph J, Cantley, Lewis C

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Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport von Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew, Rutter, Jared, Merritt, Matthew E., DeBerardinis, Ralph J.

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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells von Chen, Pei-Hsuan, Cai, Ling, Huffman, Kenneth, Yang, Chendong, Kim, Jiyeon, Faubert, Brandon, Boroughs, Lindsey, Ko, Bookyung, Sudderth, Jessica, McMillan, Elizabeth A., Girard, Luc, Chen, Dong, Peyton, Michael, Shields, Misty D., Yao, Bo, Shames, David S., Kim, Hyun Seok, Timmons, Brenda, Sekine, Ikuo, Britt, Rebecca, Weber, Stephanie, Byers, Lauren A., Heymach, John V., Chen, Jing, White, Michael A., Minna, John D., Xiao, Guanghua, DeBerardinis, Ralph J.

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells von Cheng, Tzuling, Sudderth, Jessica, Yang, Chendong, Mullen, Andrew R, Jin, Eunsook S, Matés, José M, DeBerardinis, Ralph J

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Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid von Menon, Deepak, Salloum, Darin, Bernfeld, Elyssa, Gorodetsky, Elizabeth, Akselrod, Alla, Frias, Maria A., Sudderth, Jessica, Chen, Pei-Hsuan, DeBerardinis, Ralph, Foster, David A.

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Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling von CHENDONG YANG, SUDDERTH, Jessica, TUYEN DANG, BACHOO, Robert G, MCDONALD, Jeffrey G, DEBERARDINIS, Ralph J

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Lkb1 deficiency confers glutamine dependency in polycystic kidney disease von Flowers, Ebony M., Sudderth, Jessica, Zacharias, Lauren, Mernaugh, Glenda, Zent, Roy, DeBerardinis, Ralph J., Carroll, Thomas J.

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Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer von McMillan, Elizabeth A., Ryu, Myung-Jeom, Diep, Caroline H., Mendiratta, Saurabh, Clemenceau, Jean R., Vaden, Rachel M., Kim, Ju-Hwa, Motoyaji, Takashi, Covington, Kyle R., Peyton, Michael, Huffman, Kenneth, Wu, Xiaofeng, Girard, Luc, Sung, Yeojin, Chen, Pei-Hsaun, Mallipeddi, Prema L., Lee, Joo Young, Hanson, Jordan, Voruganti, Sukesh, Yu, Yunku, Park, Sunho, Sudderth, Jessica, DeSevo, Christopher, Muzny, Donna M., Doddapaneni, HarshaVardhan, Gazdar, Adi, Gibbs, Richard A., Hwang, Tae-Hyun, Heymach, John V., Wistuba, Ignacio, Coombes, Kevin R., Williams, Noelle S., Wheeler, David A., MacMillan, John B., Deberardinis, Ralph J., Roth, Michael G., Posner, Bruce A., Minna, John D., Kim, Hyun Seok, White, Michael A.

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Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth von Shan, Changliang, Elf, Shannon, Ji, Quanjiang, Kang, Hee-Bum, Zhou, Lu, Hitosugi, Taro, Jin, Lingtao, Lin, Ruiting, Zhang, Liang, Seo, Jae Ho, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng R., Wang, Dongsheng, Chen, Georgia Zhuo, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing

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D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2 von Lin, An-Ping, Abbas, Saman, Kim, Sang-Woo, Ortega, Manoela, Bouamar, Hakim, Escobedo, Yissela, Varadarajan, Prakash, Qin, Yuejuan, Sudderth, Jessica, Schulz, Eduard, Deutsch, Alexander, Mohan, Sumitra, Ulz, Peter, Neumeister, Peter, Rakheja, Dinesh, Gao, Xiaoli, Hinck, Andrew, Weintraub, Susan T., DeBerardinis, Ralph J., Sill, Heinz, Dahia, Patricia L. M., Aguiar, Ricardo C. T.

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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism von Updegraff, Barrett L., Zhou, Xiaorong, Guo, Yabin, Padanad, Mahesh S., Chen, Pei-Hsuan, Yang, Chendong, Sudderth, Jessica, Rodriguez-Tirado, Carla, Girard, Luc, Minna, John D., Mishra, Prashant, DeBerardinis, Ralph J., O’Donnell, Kathryn A.

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A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels von Lanning, Nathan J., Looyenga, Brendan D., Kauffman, Audra L., Niemi, Natalie M., Sudderth, Jessica, DeBerardinis, Ralph J., MacKeigan, Jeffrey P.

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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma von Eskiocak, Banu, McMillan, Elizabeth A, Mendiratta, Saurabh, Kollipara, Rahul K, Zhang, Hailei, Humphries, Caroline G, Wang, Changguang, Garcia-Rodriguez, Jose, Ding, Ming, Zaman, Aubhishek, Rosales, Tracy I, Eskiocak, Ugur, Smith, Michael P, Sudderth, Jessica, Komurov, Kakajan, Deberardinis, Ralph J, Wellbrock, Claudia, Davies, Michael A, Wargo, Jennifer A, Yu, Yonghao, De Brabander, Jef K, Williams, Noelle S, Chin, Lynda, Rizos, Helen, Long, Georgina V, Kittler, Ralf, White, Michael A

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Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine von Cetinbas, Naniye Mallı, Sudderth, Jessica, Harris, Robert C., Cebeci, Aysun, Negri, Gian L., Yılmaz, Ömer H., DeBerardinis, Ralph J., Sorensen, Poul H.

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Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function von MacPherson, Sarah, Keyes, Sarah, Kilgour, Marisa K., Smazynski, Julian, Chan, Vanessa, Sudderth, Jessica, Turcotte, Tim, Devlieger, Adria, Yu, Jessie, Huggler, Kimberly S., Cantor, Jason R., DeBerardinis, Ralph J., Siatskas, Christopher, Lum, Julian J.

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Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers von Huffman, Kenneth E, Li, Long Shan, Carstens, Ryan, Park, Hyunsil, Girard, Luc, Avila, Kimberley, Wei, Shuguang, Kollipara, Rahul, Timmons, Brenda, Sudderth, Jessica, Bendris, Nawal, Kim, Jiyeon, Villalobos, Pamela, Fujimoto, Junya, Schmid, Sandra, Deberardinis, Ralph J, Wistuba, Ignacio, Heymach, John, Kittler, Ralf, Akbay, Esra A, Posner, Bruce, Wang, Yuzhuo, Lam, Stephen, Kliewer, Steven A, Mangelsdorf, David J, Minna, John D

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Optimized protocol for stable isotope tracing and steady-state metabolomics in mouse HER2+ breast cancer brain metastasis von Parida, Pravat Kumar, Marquez-Palencia, Mauricio, Kaushik, Akash K., Kim, Kangsan, Nair, Vidhya, Sudderth, Jessica, Vu, Hieu, Zacharias, Lauren, DeBerardinis, Ralph, Malladi, Srinivas

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Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic 13C Magnetic Resonance Spectroscopy von Stender, Stefan, Zaha, Vlad G., Malloy, Craig R., Sudderth, Jessica, DeBerardinis, Ralph J., Park, Jae Mo

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Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation von Tarasenko, Tatyana N., Pacheco, Susan E., Koenig, Mary Kay, Gomez-Rodriguez, Julio, Kapnick, Senta M., Diaz, Francisca, Zerfas, Patricia M., Barca, Emanuele, Sudderth, Jessica, DeBerardinis, Ralph J., Covian, Raul, Balaban, Robert S., DiMauro, Salvatore, McGuire, Peter J.

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