The allure of targets for novel drugs von Suckling, Colin J

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Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts von Corbet, Marlene, Pineda, Miguel A., Yang, Kun, Tarafdar, Anuradha, McGrath, Sarah, Nakagawa, Rinako, Lumb, Felicity E., Suckling, Colin J., Harnett, William, Harnett, Margaret M.

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Minor groove binders as anti-infective agents von BARRETT, Michael P, GEMMELL, Curtis G, SUCKLING, Colin J

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Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3- b ]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling von Riley, Christopher, Ammar, Usama, Alsfouk, Aisha, Anthony, Nahoum G, Baiget, Jessica, Berretta, Giacomo, Breen, David, Huggan, Judith, Lawson, Christopher, McIntosh, Kathryn, Plevin, Robin, Suckling, Colin J, Young, Louise C, Paul, Andrew, Mackay, Simon P

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Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression von Jones, Katherine L., Beaumont, Dominic M., Bernard, Sharon G., Bit, Rino A., Campbell, Simon P., Chung, Chun-wa, Cutler, Leanne, Demont, Emmanuel H., Dennis, Kate, Gordon, Laurie, Gray, James R., Haase, Michael, Lewis, Antonia J., McCleary, Scott, Mitchell, Darren J., Moore, Susanne M., Parr, Nigel, Robb, Olivia J., Smithers, Nicholas, Soden, Peter E., Suckling, Colin J., Taylor, Simon, Walker, Ann L., Watson, Robert J., Prinjha, Rab K.

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Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles von Bochatay, Valentin N, Boissarie, Patrick J, Murphy, John A, Suckling, Colin J, Lang, Stuart

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A Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles von Boissarie, Patrick J, Hamilton, Zoë E, Lang, Stuart, Murphy, John A, Suckling, Colin J

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The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing von Harnett, Margaret M, Doonan, James, Lumb, Felicity E, Crowe, Jenny, Damink, Roel Olde, Buitrago, Geraldine, Duncombe-Moore, Josephine, Wilkinson, Debbie I, Suckling, Colin J, Selman, Colin, Harnett, William

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Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model von Lumb, Felicity E., Crowe, Jenny, Doonan, James, Suckling, Colin J., Selman, Colin, Harnett, Margaret M., Harnett, William

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Protection against lung pathology during obesity-accelerated ageing in mice by the parasitic worm product ES-62 von Harnett, Margaret M, Lumb, Felicity E, Crowe, Jenny, Doonan, James, Buitrago, Geraldine, Brown, Stephanie, Thom, Gillian, MacDonald, Amy, Suckling, Colin J, Selman, Colin, Harnett, William

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Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease von Doonan, James, Thomas, David, Wong, Michelle H, Ramage, Hazel J, Al-Riyami, Lamyaa, Lumb, Felicity E, Bell, Kara S, Fairlie-Clarke, Karen J, Suckling, Colin J, Michelsen, Kathrin S, Jiang, Hui-Rong, Cooke, Anne, Harnett, Margaret M, Harnett, William

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Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe von Humphreys, Philip G, Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D, Gordon, Laurie, Grandi, Paola, Hayhow, Thomas G, Hussain, Jameed, Jones, Katherine L, Lindon, Matthew, Michon, Anne-Marie, Renaux, Jessica F, Suckling, Colin J, Tough, David F, Prinjha, Rab K

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Mycobacterium tuberculosis Decaprenylphosphoryl-β‑d‑ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity von Borthwick, Jennifer A, Alemparte, Carlos, Wall, Ian, Whitehurst, Benjamin C, Argyrou, Argyrides, Burley, Glenn, de Dios-Anton, Paco, Guijarro, Laura, Monteiro, Maria Candida, Ortega, Fatima, Suckling, Colin J, Pichel, Julia Castro, Cacho, Monica, Young, Robert J

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Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis von Doonan, James, Lumb, Felicity E, Pineda, Miguel A, Tarafdar, Anuradha, Crowe, Jenny, Khan, Aneesah M, Suckling, Colin J, Harnett, Margaret M, Harnett, William

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Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62 von Lumb, Felicity E., Doonan, James, Bell, Kara S., Pineda, Miguel A., Corbet, Marlene, Suckling, Colin J., Harnett, Margaret M., Harnett, William

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Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification von Perieteanu, Marina C, McGee, Leah M C, Shaw, Craig D, MacMillan, Donna S, Khalaf, Abedawn I, Gillingwater, Kirsten, Beveridge, Rebecca, Carter, Katharine C, Suckling, Colin J, Scott, Fraser J

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Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced A... von Al-Riyami, Lamyaa, Pineda, Miguel A, Rzepecka, Justyna, Huggan, Judith K, Khalaf, Abedawn I, Suckling, Colin J, Scott, Fraser J, Rodgers, David T, Harnett, Margaret M, Harnett, William

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Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model von Giordani, Federica, Khalaf, Abedawn I, Gillingwater, Kirsten, Munday, Jane C, de Koning, Harry P, Suckling, Colin J, Barrett, Michael P, Scott, Fraser J

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The diversity‐oriented synthesis of pteridines—achievements and potential for development von Suckling, Colin J.

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Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection von Kieswetter, Nathan S., Ozturk, Mumin, Hlaka, Lerato, Chia, Julius Ebua, Nichol, Ryan J. O., Cross, Jasmine M., McGee, Leah M. C., Tyson-Hirst, Izaak, Beveridge, Rebecca, Brombacher, Frank, Carter, Katharine C., Suckling, Colin J., Scott, Fraser J., Guler, Reto

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