Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea von Alvarez-Larrán, Alberto, Díaz-González, Alvaro, Such, Esperanza, Mora, Elvira, Andrade-Campos, Marcio, García-Hernández, Carmen, Gómez-Casares, M. Teresa, García-Gutiérrez, Valentín, Carreño-Tarragona, Gonzalo, Garrote, Marta, Fernández-Ibarrondo, Lierni, Cervera, José, Bellosillo, Beatriz, Cervantes, Francisco, Hernández-Boluda, Juan Carlos

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Cytogenetic risk stratification in chronic myelomonocytic leukemia von SUCH, Esperanza, CERVERA, José, NOMDEDEU, Benet, MALLO, Mar, CARBONELL, Felix, BUENO, Javier, ARDANAZ, María T, RAMOS, Fernando, TORMO, Mar, SANCHO-TELLO, Reyes, DEL CANIZO, Consuelo, GOMEZ, Valle, COSTA, Dolors, MARCO, Victor, XICOY, Blanca, BONANAD, Santiago, PEDRO, Carmen, BERNAL, Teresa, SANZ, Guillermo F, SOLE, Francesc, VALLESPI, Teresa, LUNO, Elisa, COLLADO, Rosa, CALASANZ, María J, HERNANDEZ-RIVAS, Jesus M, CIGUDOSA, Juan C

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Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7 von Crisà, Elena, Kulasekararaj, Austin G., Adema, Vera, Such, Esperanza, Schanz, Julie, Haase, Detlef, Shirneshan, Katayoon, Best, Steven, Mian, Syed A, Kizilors, Aytug, Cervera, José, Lea, Nicholas, Ferrero, Dario, Germing, Ulrich, Hildebrandt, Barbara, Martínez, Ana Belén Valencia, Santini, Valeria, Sanz, Guillermo F., Solé, Francesc, Mufti, Ghulam J.

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Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes von Cedena, M Teresa, Rapado, Inmaculada, Santos-Lozano, Alejandro, Ayala, Rosa, Onecha, Esther, Abaigar, María, Such, Esperanza, Ramos, Fernando, Cervera, José, Díez-Campelo, María, Sanz, Guillermo, Rivas, Jesús Hernández, Lucía, Alejandro, Martínez-López, Joaquin

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Outcomes and effect of somatic mutations after erythropoiesis stimulating agents in patients with lower-risk myelodysplastic syndromes von Caballero, Juan Carlos, Dávila, Julio, López-Pavía, María, Such, Esperanza, Bernal, Teresa, Ramos, Fernando, Calabuig, Marisa, Hernández Sánchez, Jesús María, Pomares, Helena, Sánchez Barba, Mercedes, Abáigar, María, González, Bernardo, Merchán, Brayan, Sancho-Tello, Reyes, Callejas, Marta, Muñoz-Novas, Carolina, Cerveró, Carlos, Sanz, Guillermo, Hernández Rivas, Jesús María, Díez Campelo, María

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Case Report: Partial Uniparental Disomy Unmasks a Novel Recessive Mutation in the LYST Gene in a Patient With a Severe Phenotype of Chédiak-Higashi Syndrome von Boluda-Navarro, Mireia, Ibáñez, Mariam, Liquori, Alessandro, Franco-Jarava, Clara, Martínez-Gallo, Mónica, Rodríguez-Vega, Héctor, Teresa, Jaijo, Carreras, Carmen, Such, Esperanza, Zúñiga, Ángel, Colobran, Roger, Cervera, José Vicente

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Analysis of SNP Array Abnormalities in Patients with DE NOVO Acute Myeloid Leukemia with Normal Karyotype von Ibáñez, Mariam, Such, Esperanza, Onecha, Esther, Gómez-Seguí, Inés, Liquori, Alessandro, Sellés, Jorge, Hervás-Marín, David, Barragán, Eva, Ayala, Rosa, LLop, Marta, López-Pavía, María, Rapado, Inmaculada, Neef, Alex, Sanjuan-Pla, Alejandra, Sargas, Claudia, Gonzalez-Romero, Elisa, Boluda-Navarro, Mireia, Andreu, Rafa, Senent, Leonor, Montesinos, Pau, Martínez-López, Joaquín, Angel Sanz, Miguel, Sanz, Guillermo, Cervera, José

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The Mutational Landscape of Acute Promyelocytic Leukemia Reveals an Interacting Network of Co-Occurrences and Recurrent Mutations von Ibáñez, Mariam, Carbonell-Caballero, José, García-Alonso, Luz, Such, Esperanza, Jiménez-Almazán, Jorge, Vidal, Enrique, Barragán, Eva, López-Pavía, María, LLop, Marta, Martín, Iván, Gómez-Seguí, Inés, Montesinos, Pau, Sanz, Miguel A, Dopazo, Joaquín, Cervera, José

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Do next-generation sequencing results drive diagnostic and therapeutic decisions in MDS? von Sanz, Guillermo F., Ibañez, Mariam, Such, Esperanza

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The modular network structure of the mutational landscape of Acute Myeloid Leukemia von Ibáñez, Mariam, Carbonell-Caballero, José, Such, Esperanza, García-Alonso, Luz, Liquori, Alessandro, López-Pavía, María, Llop, Marta, Alonso, Carmen, Barragán, Eva, Gómez-Seguí, Inés, Neef, Alexander, Hervás, David, Montesinos, Pau, Sanz, Guillermo, Sanz, Miguel Angel, Dopazo, Joaquín, Cervera, José

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Imiquimod inhibits growth and induces differentiation of myeloid leukemia cell lines von Villamón, Eva, González-Fernández, Javier, Such, Esperanza, Cervera, José Vicente, Gozalbo, Daniel, Luisa Gil, M

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Comprehensive detection of CRLF2 alterations in acute lymphoblastic leukemia: a rapid and accurate novel approach von Gil, José Vicente, Miralles, Alberto, de Las Heras, Sandra, Such, Esperanza, Avetisyan, Gayane, Díaz-González, Álvaro, Santiago, Marta, Fuentes, Carolina, Fernández, José María, Lloret, Pilar, Navarro, Irene, Montesinos, Pau, Llop, Marta, Barragán, Eva

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Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes von Martínez-Losada, Carmen, Serrano-López, Juana, Serrano-López, Josefina, Noguera, Nelida I, Garza, Eduardo, Piredda, Liliana, Lavorgna, Serena, Consalvo, María Antonietta Irno, Ottone, Tiziana, Alfonso, Valentina, Peinado, Juan Ramón, Garcia-Ortiz, María Victoria, Morales-Ruiz, Teresa, Jérez, Andrés, Hurtado, Ana María, Montesinos, Pau, Cervera, José, Such, Esperanza, Ibañez, Marian, Sempere, Amparo, Sanz, Miguel Ángel, Lo-Coco, Francesco, Sánchez-García, Joaquín

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P714: DISSECTING THE CLINICAL HETEROGENEITY OF ISOLATED TRISOMY 8 MYELODYSPLASTIC SYNDROMES THROUGH MUTATIONAL PROFILE von María Toribio Castelló, Sofía, Castaño, Sandra, Villaverde‐Ramiro, Angela, Such, Esperanza, Arnan, Montserrat, Solé, Francesc, Díaz Beyá, Marina, Díez‐Campelo, María, Rey, Mónica, González, Teresa, Hernández Rivas, Jesus

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PB2477: INTEGRATION OF OPTICAL GENOME MAPPING IN DAILY CYTOGENETICS LABORATORY ROUTINE von Díaz González, Álvaro, Avetisyan, Gayane, Garcia‐Ruiz, Cristian, Vicente Gil, José, Santiago, Marta, José Domínguez‐García, Juan, Llop, Marta, Barragan, Eva, Leonor Senent Peris, Maria, DE LA Rubia, Javier, Cervera, José, Such, Esperanza

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Regions of homozygosity confer a worse prognostic impact in myelodysplastic syndrome with normal karyotype von Mallo, Mar, Tuechler, Heinz, Arenillas, Leonor, Raynaud, Sophie, Cluzeau, Thomas, Shih, Lee‐Yung, Tung‐Liang, Chiang, Ganster, Christina, Shirneshan, Katayoon, Haase, Detlef, Mascaró, Martí, Palomo, Laura, Cervera, José, Such, Esperanza, Trim, Nicola, Jeffries, Sally, Ridgway, Emma, Marconi, Giovanni, Martinelli, Giovanni, Solé, Francesc

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A polymorphism in the XPD gene predisposes to leukemic transformation and new nonmyeloid malignancies in essential thrombocythemia and polycythemia vera von Hernández-Boluda, Juan-Carlos, Pereira, Arturo, Cervantes, Francisco, Alvarez-Larrán, Alberto, Collado, María, Such, Esperanza, Arilla, M. Jesús, Boqué, Concepción, Xicoy, Blanca, Maffioli, Margherita, Bellosillo, Beatriz, Marugán, Isabel, Amat, Paula, Besses, Carles, Guillem, Vicent

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P343: MUTATIONS IN GENES RELATED TO EPIGENETIC REGULATION, TREATMENT RESISTANCE AND IKZF1 PLUS PROFILE IDENTIFY RELAPSE PROFILES IN B‐ALL von Valle Navas Acosta, Josgrey, Gonzalez, Teresa, Serramito, Inmaculada, Miguel, Cristina, Santos, Sandra, Villaverde, Angela, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Sánchez, Ricardo, Such, Esperanza, Barrera, Susana, Ciudad, Juana, Orfao, Alberto, Maria Ribera, Josep, Dávila Valls, Julio, De Las Heras Rodriguez, Natalia, Luis Fuster, José, García de Coca, Alfonso, Labrador, Jorge, Antonio Queizan, Jose, Carmen Mendoza, Mª, Riesco, Susana, Benito, Rocío, Hernández Rivas, Jesus

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Lineage switch from B lymphoblastic leukemia with KMT2A -rearranged to mixed-phenotype acute leukemia under daratumumab von Marco-Ayala, Javier, Vicente, Ana Isabel, Such, Esperanza, Luna, Irene, Andreu, Rafael, Sempere, Amparo, Romero, Samuel, Peris, María Leonor Senent

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Panel Sequencing for Clinically Oriented Variant Screening and Copy Number Detection in Chronic Lymphocytic Leukemia Patients von Ibáñez, Mariam, Such, Esperanza, Liquori, Alessandro, Avestisyan, Gayane, Andreu, Rafael, Vicente, Ana, Macián, María José, Melendez, Mari Carmen, Morote-Faubel, Mireya, Asensi, Pedro, Lloret, María Pilar, Jarque, Isidro, Picón, Isabel, Pacios, Alejandro, Donato, Eva, Mas-Ochoa, Carmen, Alonso, Carmen, Cañigral, Carolina, Sempere, Amparo, Romero, Samuel, Santiago, Marta, Sanz, Guillermo F, de la Rubia, Javier, Senent, Leonor, Luna, Irene

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