Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection von Flanagan, Mark E, Blumenkopf, Todd A, Brissette, William H, Brown, Matthew F, Casavant, Jeffrey M, Shang-Poa, Chang, Doty, Jonathan L, Elliott, Eileen A, Fisher, Michael B, Hines, Michael, Kent, Craig, Kudlacz, Elizabeth M, Lillie, Brett M, Magnuson, Kelly S, McCurdy, Sandra P, Munchhof, Michael J, Perry, Bret D, Sawyer, Perry S, Strelevitz, Timothy J, Subramanyam, Chakrapani, Sun, Jianmin, Whipple, David A, Changelian, Paul S

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Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice von Gould, Nathaniel L, Scherer, Gila R, Carvalho, Silvia, Shurrush, Khriesto, Kayyal, Haneen, Edry, Efrat, Elkobi, Alina, David, Orit, Foqara, Maria, Thakar, Darshit, Pavesi, Tommaso, Sharma, Vijendra, Walker, Matthew, Maitland, Matthew, Dym, Orly, Albeck, Shira, Peleg, Yoav, Germain, Nicolas, Babaev, Ilana, Sharir, Haleli, Lalzar, Maya, Shklyar, Boris, Hazut, Neta, Khamaisy, Mohammad, Lévesque, Maxime, Lajoie, Gilles, Avoli, Massimo, Amitai, Gabriel, Lefker, Bruce, Subramanyam, Chakrapani, Shilton, Brian, Barr, Haim, Rosenblum, Kobi

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Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin von Betts, Alison M., Haddish-Berhane, Nahor, Tolsma, John, Jasper, Paul, King, Lindsay E., Sun, Yongliang, Chakrapani, Subramanyam, Shor, Boris, Boni, Joseph, Johnson, Theodore R.

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Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate von Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L Nathan, Sapra, Puja, Subramanyam, Chakrapani, O'Donnell, Christopher J, Graziani, Edmund I

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Design of Selective, ATP-Competitive Inhibitors of Akt von Freeman-Cook, Kevin D, Autry, Christopher, Borzillo, Gary, Gordon, Deborah, Barbacci-Tobin, Elsa, Bernardo, Vincent, Briere, David, Clark, Tracey, Corbett, Matthew, Jakubczak, John, Kakar, Shefali, Knauth, Elizabeth, Lippa, Blaise, Luzzio, Michael J, Mansour, Mahmoud, Martinelli, Gary, Marx, Matthew, Nelson, Kendra, Pandit, Jayvardhan, Rajamohan, Francis, Robinson, Shaughnessy, Subramanyam, Chakrapani, Wei, Liuqing, Wythes, Martin, Morris, Joel

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LC/MS Methods for Studying Lysosomal ADC Catabolism von Bessire, Andrew J., Subramanyam, Chakrapani

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Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor von Shraga, Amit, Olshvang, Evgenia, Davidzohn, Natalia, Khoshkenar, Payam, Germain, Nicolas, Shurrush, Khriesto, Carvalho, Silvia, Avram, Liat, Albeck, Shira, Unger, Tamar, Lefker, Bruce, Subramanyam, Chakrapani, Hudkins, Robert L., Mitchell, Amir, Shulman, Ziv, Kinoshita, Takayoshi, London, Nir

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Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor von Stepan, Antonia F, Subramanyam, Chakrapani, Efremov, Ivan V, Dutra, Jason K, O’Sullivan, Theresa J, DiRico, Kenneth J, McDonald, W. Scott, Won, Annie, Dorff, Peter H, Nolan, Charles E, Becker, Stacey L, Pustilnik, Leslie R, Riddell, David R, Kauffman, Gregory W, Kormos, Bethany L, Zhang, Liming, Lu, Yasong, Capetta, Steven H, Green, Michael E, Karki, Kapil, Sibley, Evelyn, Atchison, Kevin P, Hallgren, Andrew J, Oborski, Christine E, Robshaw, Ashley E, Sneed, Blossom, O’Donnell, Christopher J

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Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal Modifications von Maderna, Andreas, Doroski, Matthew, Subramanyam, Chakrapani, Porte, Alexander, Leverett, Carolyn A, Vetelino, Beth C, Chen, Zecheng, Risley, Hud, Parris, Kevin, Pandit, Jayvardhan, Varghese, Alison H, Shanker, Suman, Song, Cynthia, Sukuru, Sai Chetan K, Farley, Kathleen A, Wagenaar, Melissa M, Shapiro, Michael J, Musto, Sylvia, Lam, My-Hanh, Loganzo, Frank, O’Donnell, Christopher J

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Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads von Puthenveetil, Sujiet, Loganzo, Frank, He, Haiyin, Dirico, Ken, Green, Michael, Teske, Jesse, Musto, Sylvia, Clark, Tracey, Rago, Brian, Koehn, Frank, Veneziale, Robert, Falahaptisheh, Hadi, Han, Xiaogang, Barletta, Frank, Lucas, Judy, Subramanyam, Chakrapani, O’Donnell, Christopher J, Tumey, L. Nathan, Sapra, Puja, Gerber, Hans Peter, Ma, Dangshe, Graziani, Edmund I

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Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade von Hooper, Andrea T, Marquette, Kimberly, Chang, Chao-Pei Betty, Golas, Jonathon, Jain, Sadhana, Lam, My-Hanh, Guffroy, Magali, Leal, Mauricio, Falahatpisheh, Hadi, Mathur, Divya, Chen, Ting, Kelleher, Kerry, Khandke, Kiran, Muszynska, Elwira, Loganzo, Frank, Rosfjord, Edward, Lucas, Judy, Kan, Zhengyan, Subramanyam, Chakrapani, O'Donnell, Christopher, Neri, Dario, Gerber, Hans-Peter, May, Chad, Sapra, Puja

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A chemical probe to modulate human GID4 Pro/N-degron interactions von Owens, Dominic D. G., Maitland, Matthew E. R., Khalili Yazdi, Aliakbar, Song, Xiaosheng, Reber, Viviane, Schwalm, Martin P., Machado, Raquel A. C., Bauer, Nicolas, Wang, Xu, Szewczyk, Magdalena M., Dong, Cheng, Dong, Aiping, Loppnau, Peter, Calabrese, Matthew F., Dowling, Matthew S., Lee, Jisun, Montgomery, Justin I., O’Connell, Thomas N., Subramanyam, Chakrapani, Wang, Feng, Adamson, Ella C., Schapira, Matthieu, Gstaiger, Matthias, Knapp, Stefan, Vedadi, Masoud, Min, Jinrong, Lajoie, Gilles A., Barsyte-Lovejoy, Dalia, Owen, Dafydd R., Schild-Poulter, Caroline, Arrowsmith, Cheryl H.

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Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer’s Disease von Pettersson, Martin, Johnson, Douglas S., Humphrey, John M., am Ende, Christopher W., Butler, Todd W., Dorff, Peter H., Efremov, Ivan V., Evrard, Edelweiss, Green, Michael E., Helal, Christopher J., Kauffman, Gregory W., Mullins, Patrick B., Navaratnam, Thayalan, O’Donnell, Christopher J., O’Sullivan, Theresa J., Patel, Nandini C., Stepan, Antonia F., Stiff, Cory M., Subramanyam, Chakrapani, Trapa, Patrick, Tran, Tuan P., Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Pustilnik, Leslie R., Steyn, Stefanus J., Wood, Kathleen M., Bales, Kelly R., Hajos-Korcsok, Eva, Verhoest, Patrick R.

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Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim von Heaslet, Holly, Harris, Melissa, Fahnoe, Kelly, Sarver, Ronald, Putz, Henry, Chang, Jeanne, Subramanyam, Chakrapani, Barreiro, Gabriela, Miller, J. Richard

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Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation von Bessire, Andrew J, Ballard, T. Eric, Charati, Manoj, Cohen, Justin, Green, Michael, Lam, My-Hanh, Loganzo, Frank, Nolting, Birte, Pierce, Betsy, Puthenveetil, Sujiet, Roberts, Lee, Schildknegt, Klaas, Subramanyam, Chakrapani

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Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis von Helal, Christopher J, Bundesmann, Mark, Hammond, Susan, Holmstrom, Melissa, Klug-McLeod, Jacquelyn, Lefker, Bruce A, McLeod, Dale, Subramanyam, Chakrapani, Zakaryants, Oleg, Sakata, Sylvie

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Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV von Mitton-Fry, Mark J., Brickner, Steven J., Hamel, Judith C., Barham, Rose, Brennan, Lori, Casavant, Jeffrey M., Ding, Xiaoyuan, Finegan, Steven, Hardink, Joel, Hoang, Thuy, Huband, Michael D., Maloney, Meghan, Marfat, Anthony, McCurdy, Sandra P., McLeod, Dale, Subramanyam, Chakrapani, Plotkin, Michael, Reilly, Usa, Schafer, John, Stone, Gregory G., Uccello, Daniel P., Wisialowski, Todd, Yoon, Kwansik, Zaniewski, Richard, Zook, Christopher

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Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors von Stepan, Antonia F, Karki, Kapil, McDonald, W. Scott, Dorff, Peter H, Dutra, Jason K, DiRico, Kenneth J, Won, Annie, Subramanyam, Chakrapani, Efremov, Ivan V, O’Donnell, Christopher J, Nolan, Charles E, Becker, Stacey L, Pustilnik, Leslie R, Sneed, Blossom, Sun, Hao, Lu, Yasong, Robshaw, Ashley E, Riddell, David, O'Sullivan, Theresa J, Sibley, Evelyn, Capetta, Steven, Atchison, Kevin, Hallgren, Andrew J, Miller, Emily, Wood, Anthony, Obach, R. Scott

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Increased building block access through collaboration von Helal, Christopher J., Bartolozzi, Alessandra, Goble, Steven D., Mani, Neelakanda S., Guzman-Perez, Angel, Ohri, Ajay K., Shi, Zhi-Cai, Subramanyam, Chakrapani

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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex von Yazdi, Aliakbar Khalili, Perveen, Sumera, Dong, Cheng, Song, Xiaosheng, Dong, Aiping, Szewczyk, Magdalena M, Calabrese, Matthew F, Casimiro-Garcia, Agustin, Chakrapani, Subramanyam, Dowling, Matthew S, Ficici, Emel, Lee, Jisun, Montgomery, Justin I, O'Connell, Thomas N, Skrzypek, Grzegorz J, Tran, Tuan P, Troutman, Matthew D, Wang, Feng, Young, Jennifer A, Min, Jinrong, Barsyte-Lovejoy, Dalia, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Vedadi, Masoud, Owen, Dafydd R

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