Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity von Hafner, Marc, Mills, Caitlin E., Subramanian, Kartik, Chen, Chen, Chung, Mirra, Boswell, Sarah A., Everley, Robert A., Liu, Changchang, Walmsley, Charlotte S., Juric, Dejan, Sorger, Peter K.

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From word models to executable models of signaling networks using automated assembly von Gyori, Benjamin M, Bachman, John A, Subramanian, Kartik, Muhlich, Jeremy L, Galescu, Lucian, Sorger, Peter K

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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling von Vemulapalli, Vidyasiri, Chylek, Lily A, Erickson, Alison, Pfeiffer, Anamarija, Gabriel, Khal-Hentz, LaRochelle, Jonathan, Subramanian, Kartik, Cao, Ruili, Stegmaier, Kimberley, Mohseni, Morvarid, LaMarche, Matthew J, Acker, Michael G, Sorger, Peter K, Gygi, Steven P, Blacklow, Stephen C

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Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop von Mills, Caitlin E., Subramanian, Kartik, Hafner, Marc, Niepel, Mario, Gerosa, Luca, Chung, Mirra, Victor, Chiara, Gaudio, Benjamin, Yapp, Clarence, Nirmal, Ajit J., Clark, Nicholas, Sorger, Peter K.

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Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity von Melms, Johannes C, Vallabhaneni, Sreeram, Mills, Caitlin E, Yapp, Clarence, Chen, Jia-Yun, Morelli, Eugenio, Waszyk, Patricia, Kumar, Sushil, Deming, Derrick, Moret, Nienke, Rodriguez, Steven, Subramanian, Kartik, Rogava, Meri, Cartwright, Adam N R, Luoma, Adrienne, Mei, Shaolin, Brinker, Titus J, Miller, David M, Spektor, Alexander, Schadendorf, Dirk, Riggi, Nicolo, Wucherpfennig, Kai W, Sorger, Peter K, Izar, Benjamin

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Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells von Subramanian, Kartik, Owens, Derek Jason, Raju, Ravali, Firpo, Meri, O'Brien, Timothy D., Verfaillie, Catherine M., Hu, Wei-Shou

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Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models von Subramanian, Kartik, Paul, Mark R, Tyson, John J

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A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line von Song, Yuyu, Subramanian, Kartik, Berberich, Matthew J., Rodriguez, Steven, Latorre, Isabel J., Luria, Catherine M., Everley, Robert, Albers, Mark W., Mitchison, Timothy J., Sorger, Peter K.

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Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells von Roelandt, Philip, Pauwelyn, Karen Ann, Sancho-Bru, Pau, Subramanian, Kartik, Bose, Bipasha, Ordovas, Laura, Vanuytsel, Kim, Geraerts, Martine, Firpo, Meri, De Vos, Rita, Fevery, Johan, Nevens, Frederik, Hu, Wei-Shou, Verfaillie, Catherine M

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Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus von Subramanian, Kartik, Paul, Mark R, Tyson, John J

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Proteomic profiling across breast cancer cell lines and models von Kalocsay, Marian, Berberich, Matthew J., Everley, Robert A., Nariya, Maulik K., Chung, Mirra, Gaudio, Benjamin, Victor, Chiara, Bradshaw, Gary A., Eisert, Robyn J., Hafner, Marc, Sorger, Peter K., Mills, Caitlin E., Subramanian, Kartik

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Enhanced Differentiation of Adult Bone Marrow-Derived Stem Cells to Liver Lineage in Aggregate Culture von Subramanian, Kartik, Owens, Derek Jason, O'Brien, Timothy D., Verfaillie, Catherine M., Hu, Wei-Shou

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A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers von Rao, Suman, Du, Guangyan, Hafner, Marc, Subramanian, Kartik, Sorger, Peter K., Gray, Nathanael S.

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Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing von Liu, Yan, Ferguson, Fleur M., Li, Lianbo, Kuljanin, Miljan, Mills, Caitlin E., Subramanian, Kartik, Harshbarger, Wayne, Gondi, Sudershan, Wang, Jinhua, Sorger, Peter K., Mancias, Joseph D., Gray, Nathanael S., Westover, Kenneth D.

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A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines von Niepel, Mario, Hafner, Marc, Mills, Caitlin E., Subramanian, Kartik, Williams, Elizabeth H., Chung, Mirra, Gaudio, Benjamin, Barrette, Anne Marie, Stern, Alan D., Hu, Bin, Korkola, James E., Shamu, Caroline E., Jayaraman, Gomathi, Azeloglu, Evren U., Iyengar, Ravi, Sobie, Eric A., Mills, Gordon B., Liby, Tiera, Jaffe, Jacob D., Alimova, Maria, Davison, Desiree, Lu, Xiaodong, Golub, Todd R., Subramanian, Aravind, Shelley, Brandon, Svendsen, Clive N., Ma’ayan, Avi, Medvedovic, Mario, Feiler, Heidi S., Smith, Rebecca, Devlin, Kaylyn, Gray, Joe W., Birtwistle, Marc R., Heiser, Laura M., Sorger, Peter K.

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Abstract 4432: Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and its impact on drug response von Mills, Caitlin E., Hafner, Marc A., Subramanian, Kartik, Chen, Chen, Chung, Mirra, Boswell, Sarah A., Everley, Robert A., Liu, Changchang, Walmsley, Charlotte S., Juric, Dejan, Sorger, Peter K.

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Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus : A Theoretical Investigation of Alternative Models: e1004348 von Subramanian, Kartik, Paul, Mark R, Tyson, John J

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Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity von Hafner, Marc, Mills, Caitlin Elizabeth, Subramanian, Kartik, Chen, Chen, Chung, Mirra, Boswell, Sarah Ann, Everley, Robert A., Liu, Changchang, Walmsley, Charlotte Sanden, Juric, Dejan, Sorger, Peter Karl

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Abstract B60: Omics profiling of CDK4/6 inhibitors reveals functionally important secondary targets of abemaciclib von Mills, Caitlin E., Hafner, Marc, Subramanian, Kartik, Chen, Chen, Boswell, Sarah A., Everley, Robert A., Juric, Dejan, Sorger, Peter K.

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Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity von Melms, Johannes C., Vallabhaneni, Sreeram, Mills, Caitlin E., Yapp, Clarence, Chen, Jia-Yun, Morelli, Eugenio, Waszyk, Patricia, Kumar, Sushil, Deming, Derrick, Moret, Nienke, Rodriguez, Steven, Subramanian, Kartik, Rogava, Meri, Cartwright, Adam N., Luoma, Adrienne, Mei, Shaolin, Brinker, Titus J., Miller, David M., Spektor, Alexander, Schadendorf, Dirk, Riggi, Nicolo, Wucherpfennig, Kai W., Sorger, Peter K., Izar, Benjamin

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