Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder von Edmondson, Scott D, Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D, Morriello, Gregori, Harper, Bart, Moyes, Christopher R, Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N, Ha, Sookhee, Hurley, Amanda L, Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R, Ormes, James, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E

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Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity von Mangan, Paul R., Su, Linhui Julie, Jenny, Victoria, Tatum, Andrea L., Picarillo, Caryn, Skala, Stacey, Ditto, Noah, Lin, Zheng, Yang, XiaoXia, Cotter, Pete Z., Shuster, David J., Song, Yunling, Borowski, Virna, Thomas, Rochelle L., Heimrich, Elizabeth M., Devaux, Brigitte, Das Gupta, Ruchira, Carvajal, Irvith, McIntyre, Kim W., Xie, Jenny, Zhao, Qihong, Struthers, Mary, Salter-Cid, Luisa M.

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Design of a Monomeric 23-Residue Polypeptide with Defined Tertiary Structure von Struthers, Mary D., Cheng, Richard P., Imperiali, Barbara

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Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder von Moyes, Christopher R, Berger, Richard, Goble, Stephen D, Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N, Chen, Airu S, Dingley, Karen H, Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N, Hurley, Amanda L, Jochnowitz, Nina, Miller, Randall R, Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E, Edmondson, Scott D

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Utilization management and physician burnout von Struthers, Arwen, Chapman, Mary Ann, Charles, P David, Conschafter, Amanda, Cooper, Josie, Clingham, Gavin

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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells von Ward, Natasha C, Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M, Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P, Davis, Jonathan H, Struthers, Mary, Malek, Thomas R

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Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms von Ward, Natasha C, Lui, Jen Bon, Hernandez, Rosmely, Yu, Liping, Struthers, Mary, Xie, Jenny, Santos Savio, Alicia, Dwyer, Connor J, Hsiung, Sunnie, Yu, Aixin, Malek, Thomas R

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Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus von Xie, Jenny H, Zhang, Yifan, Loubeau, Martine, Mangan, Paul, Heimrich, Elizabeth, Tovar, Christian, Zhou, Xiadi, Madia, Priyanka, Doyle, Michael, Dudhgaonkar, Shailesh, Rudra, Anjuman, Subramani, Siva, Young, James, Salter-Cid, Luisa, Malek, Thomas R, Struthers, Mary

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A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines von Zhao, Qihong, Kim, Taeg, Pang, Jian, Sun, Wendy, Yang, Xiaoxia, Wang, Jinhong, Song, Yunling, Zhang, Hongwei, Sun, Huadong, Rangan, Vangipuram, Deshpande, Shrikant, Tang, Huaping, Cvijic, Mary Ellen, Westhouse, Richard, Olah, Timothy, Xie, Jenny, Struthers, Mary, Salter‐Cid, Luisa

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Economy in Protein Design:  Evolution of a Metal-Independent ββα Motif Based on the Zinc Finger Domains von Struthers, Mary D, Cheng, Richard P, Imperiali, Barbara

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Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation von Jerath, Maya R, Liu, Peng, Struthers, Mary, Demartino, Julie A, Peng, Roche, Peterson, Laurence B, Cumiskey, Anne-Marie, Yang, Lihu, Rojas, Mauricio, Patel, Dhavalkumar D, Fong, Alan M

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Tertiary Interactions between the Fifth and Sixth Transmembrane Segments of Rhodopsin von Struthers, Mary, Yu, Hongbo, Kono, Masahiro, Oprian, Daniel D.

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IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2R on regulatory T cells von Ward, Natasha C., Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M., Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P., Davis, Jonathan H., Struthers, Mary, Malek, Thomas R.

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Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension von Hoyt, Scott B., Taylor, Jerry, London, Clare, Ali, Amjad, Ujjainwalla, Feroze, Tata, Jim, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Clemas, Joe, Zhou, Gaochao, MacNeil, Douglas, Duffy, Ruth, Xiong, Yusheng

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Abstract 3760: Preclinical antitumor activity of a CC chemokine receptor (CCR) 2/5 dual antagonist as monotherapy and in combination with immune checkpoint blockade von Zhao, Qihong, Murtaza, Anwar, Bata, Adam, Sun, Wendy, Ho, Ching-Ping, Vuppugalla, Ragini, Cherney, Robert, Stefanski, Kevin, Cao, Z Alexander, Sama, Ashwin, Yang, Arvin, Struthers, Mary, Sanjuan, Miguel, Hunt, John T., Carter, Percy, Salter-Cid, Luisa

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A pilot study to investigate the use of installment dispensing as a method of reducing drug wastage owing to adverse drug reactions von Millar, John, MacKinnon, Wendy, Struthers, Mary V, Vass, Catherine

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Dual Targeting of CCR2 and CX3CR1 in an Arterial Injury Model of Vascular Inflammation von Jerath, Maya, Fellow, University of North Carolina, Department of Medicine, Chapel Hill, NC, Liu, Peng, Research Associate, University of North Carolina, Thurston Arthritis Research Center, Chapel Hill, NC, Rojas, Mauricio, Research Instructor, University of North Carolina, Department of Medicine, Chapel Hill, NC, Struthers, Mary, Research Fellow, Merck Research Laboratories, Department of Immunology, Rahway, NJ, Demartino, Julie, Senior Director, Merck Research Laboratories, Department of Immunology, Rahway, NJ, Lyons, Kathryn, Senior Research Associate, Merck Research Laboratories, Department of Medicinal Chemistry, Rahway, NJ, Peng, Ruoqi, Senior Research Immunologist, Merck Research Laboratories, Department of Immunology, Rahway, NJ, Yang, Lihu, Director, Merck Research Laboratories, Department of Medicinal Chemistry, Rahway, NJ, Patel, Dhaval, Professor, The University of North Carolina, Department of Medicine, Chapel Hill, NC

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Leukotriene B 4 Strongly Increases Monocyte Chemoattractant Protein-1 in Human Monocytes von Huang, Li, Zhao, Annie, Wong, Frederick, Ayala, Julia M., Struthers, Mary, Ujjainwalla, Feroze, Wright, Samuel D., Springer, Marty S., Evans, Jilly, Cui, Jisong

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Leukotriene B4 Strongly Increases Monocyte Chemoattractant Protein-1 in Human Monocytes von Huang, Li, Zhao, Annie, Wong, Frederick, Ayala, Julia M, Struthers, Mary, Ujjainwalla, Feroze, Wright, Samuel D, Springer, Marty S, Evans, Jilly, Cui, Jisong

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Imidazopyridyl compounds as aldosterone synthase inhibitors von Whitehead, Brent R., Lo, Michael M.-C., Ali, Amjad, Park, Min K., Hoyt, Scott B., Xiong, Yusheng, Cai, Jiaqiang, Carswell, Emma, Cooke, Andrew, MacLean, John, Ratcliffe, Paul, Robinson, John, Bennett, D. Jonathan, Clemas, Joseph A., Wisniewski, Tom, Struthers, Mary, Cully, Doris, MacNeil, Douglas J.

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