Versatility of Microbial Transglutaminase von Strop, Pavel

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Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer von Zhu, Guoyun, Foletti, Davide, Liu, Xiaohui, Ding, Sheng, Melton Witt, Jody, Hasa-Moreno, Adela, Rickert, Mathias, Holz, Charles, Aschenbrenner, Laura, Yang, Amy H., Kraynov, Eugenia, Evering, Winston, Obert, Leslie, Lee, Chenyu, Sai, Tao, Mistry, Tina, Lindquist, Kevin C., Van Blarcom, Thomas, Strop, Pavel, Chaparro-Riggers, Javier, Liu, Shu-Hui

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Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions von Wang, Feng, Chau, Bryant, West, Sean M., Kimberlin, Christopher R., Cao, Fei, Schwarz, Flavio, Aguilar, Barbara, Han, Minhua, Morishige, Winse, Bee, Christine, Dollinger, Gavin, Rajpal, Arvind, Strop, Pavel

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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design von Dorywalska, Magdalena, Dushin, Russell, Moine, Ludivine, Farias, Santiago E, Zhou, Dahui, Navaratnam, Thayalan, Lui, Victor, Hasa-Moreno, Adela, Casas, Meritxell Galindo, Tran, Thomas-Toan, Delaria, Kathy, Liu, Shu-Hui, Foletti, Davide, O'Donnell, Christopher J, Pons, Jaume, Shelton, David L, Rajpal, Arvind, Strop, Pavel

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Transglutaminase 2 undergoes a large conformational change upon activation von Pinkas, Daniel M, Strop, Pavel, Brunger, Axel T, Khosla, Chaitan

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The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels von Bavi, Navid, Cortes, D. Marien, Cox, Charles D., Rohde, Paul R., Liu, Weihong, Deitmer, Joachim W., Bavi, Omid, Strop, Pavel, Hill, Adam P., Rees, Douglas, Corry, Ben, Perozo, Eduardo, Martinac, Boris

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Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model von Zorn, Julie A., Wheeler, Matthew L., Barnes, Ralston M., Kaberna, Jim, Morishige, Winse, Harris, Marek, Huang, Richard Y.-C., Lohre, Jack, Chang, Yu Ching, Chau, Bryant, Powers, Kathleen, Schindler, Ian, Neradugomma, Naveen, Thomas, Winston, Liao, Xiaoyun, Zhou, Yinhan, West, Sean M., Wang, Feng, Kotapati, Srikanth, Chen, Guodong, Yamazoe, Sayumi, Kosenko, Anastasia, Dollinger, Gavin, Sproul, Tim, Rajpal, Arvind, Strop, Pavel

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Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another von Abdiche, Yasmina Noubia, Yeung, Andy Yik, Ni, Irene, Stone, Donna, Miles, Adam, Morishige, Winse, Rossi, Andrea, Strop, Pavel

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Tim-3 mediates T cell trogocytosis to limit antitumor immunity von Pagliano, Ornella, Morrison, Robert M, Chauvin, Joe-Marc, Banerjee, Hridesh, Davar, Diwakar, Ding, Quanquan, Tanegashima, Tokiyoshi, Gao, Wentao, Chakka, Saranya R, DeBlasio, Richelle, Lowin, Ava, Kara, Kevin, Ka, Mignane, Zidi, Bochra, Amin, Rada, Raphael, Itay, Zhang, Shuowen, Watkins, Simon C, Sander, Cindy, Kirkwood, John M, Bosenberg, Marcus, Anderson, Ana C, Kuchroo, Vijay K, Kane, Lawrence P, Korman, Alan J, Rajpal, Arvind, West, Sean M, Han, Minhua, Bee, Christine, Deng, Xiaodi, Schebye, Xiao Min, Strop, Pavel, Zarour, Hassane M

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Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies von Kotapati, Srikanth, Passmore, David, Yamazoe, Sayumi, Sanku, Rajesh Kishore Kumar, Cong, Qiang, Poudel, Yam B, Chowdari, Naidu S, Gangwar, Sanjeev, Rao, Chetana, Rangan, Vangipuram S, Cardarelli, Pina M, Deshpande, Shrikant, Strop, Pavel, Dollinger, Gavin, Rajpal, Arvind

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Refractive index‐based determination of detergent concentration and its application to the study of membrane proteins von Strop, Pavel, Brunger, Axel T.

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Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT von Diong, SJ J., Jashnani, Aarti, Drake, Andrew W., Bee, Christine, Findeisen, Felix, Dollinger, Gavin, Wang, Feng, Rajpal, Arvind, Strop, Pavel, Lee, Peter S.

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Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair von Strop, Pavel, Ho, Wei-Hsien, Boustany, Leila M., Abdiche, Yasmina N., Lindquist, Kevin C., Farias, Santiago E., Rickert, Mathias, Appah, Charles Takeshi, Pascua, Edward, Radcliffe, Teresa, Sutton, Janette, Chaparro-Riggers, Javier, Chen, Wei, Casas, Meritxell Galindo, Chin, Sherman Michael, Wong, Oi Kwan, Liu, Shu-Hui, Vergara, German, Shelton, Dave, Rajpal, Arvind, Pons, Jaume

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Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates von Liang, Hong, Chaparro-Riggers, Javier, Strop, Pavel, Geng, Tao, Sutton, Janette E, Tsai, Daniel, Bai, Lanfang, Abdiche, Yasmina, Dilley, Jeanette, Yu, Jessica, Wu, Si, Chin, S Michael, Lee, Nicole A, Rossi, Andrea, Lin, John C, Rajpal, Arvind, Pons, Jaume, Shelton, David L

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Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire von Yeung, Yik Andy, Foletti, Davide, Deng, Xiaodi, Abdiche, Yasmina, Strop, Pavel, Glanville, Jacob, Pitts, Steven, Lindquist, Kevin, Sundar, Purnima D., Sirota, Marina, Hasa-Moreno, Adela, Pham, Amber, Melton Witt, Jody, Ni, Irene, Pons, Jaume, Shelton, David, Rajpal, Arvind, Chaparro-Riggers, Javier

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Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies von Shcherbatko, Anatoly, Foletti, Davide, Poulsen, Kris, Strop, Pavel, Zhu, Guoyun, Hasa-Moreno, Adela, Melton Witt, Jody, Loo, Carole, Krimm, Stellanie, Pios, Ariel, Yu, Jessica, Brown, Colleen, Lee, John K., Stroud, Robert, Rajpal, Arvind, Shelton, David

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Improved therapeutic index of an acidic pH-selective antibody von Lee, Peter S, MacDonald, Katherine G, Massi, Evan, Chew, Pamela V, Bee, Christine, Perkins, Padma, Chau, Bryant, Thudium, Kent, Lohre, Jack, Nandi, Pradyot, Deyanova, Ekaterina G, Barman, Ishita, Gudmundsson, Olafur, Dollinger, Gavin, Sproul, Tim, Engelhardt, John J, Strop, Pavel, Rajpal, Arvind

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Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy von Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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A method for integrative structure determination of protein-protein complexes von SCHNEIDMAN-DUHOVNY, Dina, ROSSI, Andrea, SOBHANIFAR, Solmaz, DÖTSCH, Volker, RAJPAL, Arvind, PONS, Jaume, AGARD, David A, YIFAN CHENG, SALI, Andrej, AVILA-SAKAR, Agustin, SEUNG JOONG KIM, VELAZQUEZ-MURIEL, Javier, STROP, Pavel, HONG LIANG, KRUKENBERG, Kristin A, MAOFU LIAO, HO MIN KIM

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Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates von Costa, Maria José, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Ho, Wei-Hsien, Delaria, Kathy, Holz, Charles, Stauffer, Angela, Chunyk, Allison Given, Zong, Qing, Blasi, Eileen, Buetow, Bernard, Tran, Thomas-Toan, Lindquist, Kevin, Dorywalska, Magdalena, Rajpal, Arvind, Shelton, David L., Strop, Pavel, Liu, Shu-Hui

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