Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens von Behan, Fiona M., Iorio, Francesco, Picco, Gabriele, Gonçalves, Emanuel, Beaver, Charlotte M., Migliardi, Giorgia, Santos, Rita, Rao, Yanhua, Sassi, Francesco, Pinnelli, Marika, Ansari, Rizwan, Harper, Sarah, Jackson, David Adam, McRae, Rebecca, Pooley, Rachel, Wilkinson, Piers, van der Meer, Dieudonne, Dow, David, Buser-Doepner, Carolyn, Bertotti, Andrea, Trusolino, Livio, Stronach, Euan A., Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J.

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Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting von Iorio, Francesco, Behan, Fiona M, Gonçalves, Emanuel, Bhosle, Shriram G, Chen, Elisabeth, Shepherd, Rebecca, Beaver, Charlotte, Ansari, Rizwan, Pooley, Rachel, Wilkinson, Piers, Harper, Sarah, Butler, Adam P, Stronach, Euan A, Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J

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Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects von Gonçalves, Emanuel, Behan, Fiona M, Louzada, Sandra, Arnol, Damien, Stronach, Euan A, Yang, Fengtang, Yusa, Kosuke, Stegle, Oliver, Iorio, Francesco, Garnett, Mathew J

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Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer von de Wolf, Elizabeth, Abdullah, Marwan Ibrahim, Jones, Stefanie M., Menezes, Karen, Moss, Darren M., Drijfhout, Falko P., Hart, Sarah R., Hoskins, Clare, Stronach, Euan A., Richardson, Alan

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DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance von Stronach, Euan A, Chen, Michelle, Maginn, Elaina N, Agarwal, Roshan, Mills, Gordon B, Wasan, Harpreet, Gabra, Hani

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Evaluation of 2-Deoxy-2-[18F]Fluoro-D-glucose- and 3′-Deoxy-3′-[18F]Fluorothymidine–Positron Emission Tomography as Biomarkers of Therapy Response in Platinum-Resistant Ovarian Can... von Perumal, Meg, Stronach, Euan A., Gabra, Hani, Aboagye, Eric O.

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Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer von Bowtell, David D., Böhm, Steffen, Ahmed, Ahmed A., Aspuria, Paul-Joseph, Bast, Robert C., Beral, Valerie, Berek, Jonathan S., Birrer, Michael J., Blagden, Sarah, Bookman, Michael A., Brenton, James D., Chiappinelli, Katherine B., Martins, Filipe Correia, Coukos, George, Drapkin, Ronny, Edmondson, Richard, Fotopoulou, Christina, Gabra, Hani, Galon, Jérôme, Gourley, Charlie, Heong, Valerie, Huntsman, David G., Iwanicki, Marcin, Karlan, Beth Y., Kaye, Allyson, Lengyel, Ernst, Levine, Douglas A., Lu, Karen H., McNeish, Iain A., Menon, Usha, Narod, Steven A., Nelson, Brad H., Nephew, Kenneth P., Pharoah, Paul, Powell, Daniel J., Ramos, Pilar, Romero, Iris L., Scott, Clare L., Sood, Anil K., Stronach, Euan A., Balkwill, Frances R.

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Biomarker Assessment of HR Deficiency, Tumor BRCA1/2 Mutations, and CCNE1 Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy von Stronach, Euan A, Paul, James, Timms, Kirsten M, Hughes, Elisha, Brown, Krystal, Neff, Christopher, Perry, Michael, Gutin, Alexander, El-Bahrawy, Mona, Steel, Jennifer H, Liu, Xinxue, Lewsley, Liz-Anne, Siddiqui, Nadeem, Gabra, Hani, Lanchbury, Jerry S, Brown, Robert

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OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer von Sellar, Grant C, Gabra, Hani, Watt, Karen P, Rabiasz, Genevieve J, Stronach, Euan A, Li, Li, Miller, Eric P, Massie, Charles E, Miller, Jayne, Contreras-Moreira, Bruno, Scott, Diane, Brown, Iain, Williams, Alastair R, Bates, Paul A, Smyth, John F

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Comparing the Characteristics of Gene Expression Profiles Derived by Univariate and Multivariate Classification Methods von Zucknick, Manuela, Richardson, Sylvia, Stronach, Euan A

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Rethinking ovarian cancer: recommendations for improving outcomes von Bowtell, David D, Vaughan, Sebastian, Coward, Jermaine I, Bast, Robert C, Berchuck, Andy, Berek, Jonathan S, Brenton, James D, Coukos, George, Crum, Christopher C, Drapkin, Ronny, Etemadmoghadam, Dariush, Friedlander, Michael, Gabra, Hani, Kaye, Stan B, Lord, Chris J, Lengyel, Ernst, Levine, Douglas A, McNeish, Iain A, Menon, Usha, Mills, Gordon B, Nephew, Kenneth P, Oza, Amit M, Sood, Anil K, Stronach, Euan A, Walczak, Henning, Balkwill, Frances R

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Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer von Blagden, Sarah P, Hamilton, Anne L, Mileshkin, Linda, Wong, Shirley, Michael, Agnieszka, Hall, Marcia, Goh, Jeffrey C, Lisyanskaya, Alla S, DeSilvio, Michelle, Frangou, Eleni, Stronach, Euan A, Gopalakrishna, Prashanth, Meniawy, Tarek M, Gabra, Hani

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HDAC4-Regulated STAT1 Activation Mediates Platinum Resistance in Ovarian Cancer von STRONACH, Euan A, ALFRAIDI, Albandri, MAI, Antonello, BROWN, Robert, DINA, Roberto, GABRA, Hani, RAMA, Nona, DATLER, Christoph, STUDD, James B, AGARWAL, Roshan, GUNEY, Tankut G, GOURLEY, Charlie, HENNESSY, Bryan T, MILLS, Gordon B

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MicroRNAs associated with small bowel neuroendocrine tumours and their metastases von Miller, Helen C, Frampton, Adam E, Malczewska, Anna, Ottaviani, Silvia, Stronach, Euan A, Flora, Rashpal, Kaemmerer, Daniel, Schwach, Gert, Pfragner, Roswitha, Faiz, Omar, Kos-Kudła, Beata, Hanna, George B, Stebbing, Justin, Castellano, Leandro, Frilling, Andrea

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CELLector: Genomics-Guided Selection of Cancer In Vitro Models von Najgebauer, Hanna, Yang, Mi, Francies, Hayley E., Pacini, Clare, Stronach, Euan A., Garnett, Mathew J., Saez-Rodriguez, Julio, Iorio, Francesco

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The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma von Stronach, Euan A, Cunnea, Paula, Turner, Christina, Guney, Tankut, Aiyappa, Radhika, Jeyapalan, Senthuran, de Sousa, Camila H, Browne, Alacoque, Magdy, Nesreen, Studd, James B, Sriraksa, Ruethairat, Gabra, Hani, El-Bahrawy, Mona

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Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy von Dungl, Daniela A, Maginn, Elaina N, Stronach, Euan A

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Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells von Burmi, Rajpal S., Maginn, Elaina N., Gabra, Hani, Stronach, Euan A., Wasan, Harpreet S.

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Dose-Finding Quantitative 18F-FDG PET Imaging Study with the Oral Pan-AKT Inhibitor GSK2141795 in Patients with Gynecologic Malignancies von Gungor, Hatice, Saleem, Azeem, Babar, Syed, Dina, Roberto, El-Bahrawy, Mona A, Curry, Ed, Rama, Nona, Chen, Michele, Pickford, Emily, Agarwal, Roshan, Blagden, Sarah, Carme, Sabin, Salinas, Cristian, Madison, Sam, Krachey, Elizabeth, Santiago-Walker, Ademi, Smith, Deborah A, Morris, Shannon R, Stronach, Euan A, Gabra, Hani

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Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: Implications for surgical and clinical outcomes von Cunnea, Paula, Curry, Edward W., Christie, Elizabeth L., Nixon, Katherine, Kwok, Chun Hei, Pandey, Ahwan, Wulandari, Ratri, Thol, Kerstin, Ploski, Jennifer, Morera-Albert, Cristina, McQuaid, Stephen, Lozano-Kuehne, Jingky, Clark, James J., Krell, Jonathan, Stronach, Euan A., McNeish, Iain A., Bowtell, David D.L., Fotopoulou, Christina

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