Defining Left Bundle Branch Block in the Era of Cardiac Resynchronization Therapy von Strauss, David G., MD, PhD, Selvester, Ronald H., MD, Wagner, Galen S., MD

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Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk von Johannesen, Lars, Vicente, Jose, Hosseini, Meisam, Strauss, David G

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Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates) von Strauss, David G., Wu, Wendy W., Li, Zhihua, Koerner, John, Garnett, Christine

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An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel von Crumb, William J., Vicente, Jose, Johannesen, Lars, Strauss, David G.

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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress von Colatsky, Thomas, Fermini, Bernard, Gintant, Gary, Pierson, Jennifer B., Sager, Philip, Sekino, Yuko, Strauss, David G., Stockbridge, Norman

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International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment von Blinova, Ksenia, Dang, Qianyu, Millard, Daniel, Smith, Godfrey, Pierson, Jennifer, Guo, Liang, Brock, Mathew, Lu, Hua Rong, Kraushaar, Udo, Zeng, Haoyu, Shi, Hong, Zhang, Xiaoyu, Sawada, Kohei, Osada, Tomoharu, Kanda, Yasunari, Sekino, Yuko, Pang, Li, Feaster, Tromondae K., Kettenhofen, Ralf, Stockbridge, Norman, Strauss, David G., Gintant, Gary

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Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment von Yang, Xi, Ribeiro, Alexandre J S, Pang, Li, Strauss, David G

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Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study von Vicente, Jose, Zusterzeel, Robbert, Johannesen, Lars, Mason, Jay, Sager, Philip, Patel, Vikram, Matta, Murali K., Li, Zhihua, Liu, Jiang, Garnett, Christine, Stockbridge, Norman, Zineh, Issam, Strauss, David G.

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Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias von Blinova, Ksenia, Stohlman, Jayna, Vicente, Jose, Chan, Dulciana, Johannesen, Lars, Hortigon-Vinagre, Maria P, Zamora, Victor, Smith, Godfrey, Crumb, William J, Pang, Li, Lyn-Cook, Beverly, Ross, James, Brock, Mathew, Chvatal, Stacie, Millard, Daniel, Galeotti, Loriano, Stockbridge, Norman, Strauss, David G

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Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative von Li, Zhihua, Ridder, Bradley J., Han, Xiaomei, Wu, Wendy W., Sheng, Jiansong, Tran, Phu N., Wu, Min, Randolph, Aaron, Johnstone, Ross H., Mirams, Gary R., Kuryshev, Yuri, Kramer, James, Wu, Caiyun, Crumb, William J., Strauss, David G.

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Mechanisms of sex and age differences in ventricular repolarization in humans von Vicente, Jose, MS, Johannesen, Lars, MS, Galeotti, Loriano, PhD, Strauss, David G., MD, PhD

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Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment von Dutta, Sara, Chang, Kelly C, Beattie, Kylie A, Sheng, Jiansong, Tran, Phu N, Wu, Wendy W, Wu, Min, Strauss, David G, Colatsky, Thomas, Li, Zhihua

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Evaluating kratom alkaloids using PHASE von Ellis, Christopher R., Racz, Rebecca, Kruhlak, Naomi L., Kim, Marlene T., Zakharov, Alexey V., Southall, Noel, Hawkins, Edward G., Burkhart, Keith, Strauss, David G., Stavitskaya, Lidiya

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm von Fermini, Bernard, Hancox, Jules C., Abi-Gerges, Najah, Bridgland-Taylor, Matthew, Chaudhary, Khuram W., Colatsky, Thomas, Correll, Krystle, Crumb, William, Damiano, Bruce, Erdemli, Gul, Gintant, Gary, Imredy, John, Koerner, John, Kramer, James, Levesque, Paul, Li, Zhihua, Lindqvist, Anders, Obejero-Paz, Carlos A., Rampe, David, Sawada, Kohei, Strauss, David G., Vandenberg, Jamie I.

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Target Adverse Event Profiles for Predictive Safety in the Postmarket Setting von Schotland, Peter, Racz, Rebecca, Jackson, David B., Soldatos, Theodoros G., Levin, Robert, Strauss, David G., Burkhart, Keith

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Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block von Tran, Phu N., Sheng, Jiansong, Randolph, Aaron L., Baron, Claudia Alvarez, Thiebaud, Nicolas, Ren, Ming, Wu, Min, Johannesen, Lars, Volpe, Donna A., Patel, Dakshesh, Blinova, Ksenia, Strauss, David G., Wu, Wendy W.

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Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation von Rubiano, Andrés, Indapurkar, Amruta, Yokosawa, Ryosuke, Miedzik, Alina, Rosenzweig, Barry, Arefin, Ayesha, Moulin, Chloe M., Dame, Keri, Hartman, Neil, Volpe, Donna A., Matta, Murali K., Hughes, David J., Strauss, David G., Kostrzewski, Tomasz, Ribeiro, Alexandre J. S.

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Associations of electrocardiographic P-wave characteristics with left atrial function, and diffuse left ventricular fibrosis defined by cardiac magnetic resonance: The PRIMERI Stud... von Tiffany Win, Theingi, MD, Ambale Venkatesh, Bharath, PhD, Volpe, Gustavo J., MD, Mewton, Nathan, MD, PhD, Rizzi, Patricia, MD, Sharma, Ravi K., MD, Strauss, David G., MD, PhD, Lima, Joao A., MD, Tereshchenko, Larisa G., MD, PhD, FHRS

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Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment von Chang, Kelly C, Dutta, Sara, Mirams, Gary R, Beattie, Kylie A, Sheng, Jiansong, Tran, Phu N, Wu, Min, Wu, Wendy W, Colatsky, Thomas, Strauss, David G, Li, Zhihua

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Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFNβ‐1a Biologics von Hyland, Paula L., Chekka, Lakshmi Manasa S., Samarth, Deepti P., Rosenzweig, Barry A., Decker, Erica, Mohamed, Esraa G., Guo, Yan, Matta, Murali K., Sun, Qin, Wheeler, William, Sanabria, Carlos, Weaver, James L., Schrieber, Sarah J., Florian, Jeffry, Wang, Yow‐Ming, Strauss, David G.

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