Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors von Hoegenauer, Klemens, Soldermann, Nicolas, Zécri, Frédéric, Strang, Ross S, Graveleau, Nadege, Wolf, Romain M, Cooke, Nigel G, Smith, Alexander B, Hollingworth, Gregory J, Blanz, Joachim, Gutmann, Sascha, Rummel, Gabriele, Littlewood-Evans, Amanda, Burkhart, Christoph

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Molecular hybridization yields triazole bronchodilators for the treatment of COPD von Jones, Lyn H., Burrows, Jane, Feeder, Neil, Glossop, Paul, James, Kim, Jones, Rhys M., Kenyon, Amy S., Patel, Sheena, Roberts, Dannielle F., Selby, Matthew D., Strang, Ross S., Stuart, Emilio F., Trevethick, Michael A., Watson, Jessica, Wright, Karen N., Clarke, Nick

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Nonclassical Zwitterions as a Design Principle to Reduce Lipophilicity without Impacting Permeability von Möbitz, Henrik, Dittrich, Birger, Rodde, Stephane, Strang, Ross

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Development of a Scaleable Synthesis of a Geminal Dimethyl Tertiary Amine as an Inhaled Muscarinic Antagonist for the Treatment of COPD von Dillon, Barry R, Roberts, Dannielle F, Entwistle, David A, Glossop, Paul A, Knight, Craig J, Laity, Daniel A, James, Kim, Praquin, Celine F, Strang, Ross S, Watson, Christine A. L

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Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor von Owen, Dafydd R., Bull, David J., Bunnage, Mark E., Glossop, Melanie S., Maguire, Robert J., Strang, Ross S.

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Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors von Glossop, Melanie S., Bazin, Richard J., Dack, Kevin N., Fox, David N.A., MacDonald, Graeme A., Mills, Mark, Owen, Dafydd R., Phillips, Chris, Reeves, Keith A., Ringer, Tracy J., Strang, Ross S., Watson, Christine A.L.

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers von Ferretti, Stephane, Hamon, Jacques, de Kanter, Ruben, Scheufler, Clemens, Andraos-Rey, Rita, Barbe, Stephanie, Bechter, Elisabeth, Blank, Jutta, Bordas, Vincent, Dammassa, Ernesta, Decker, Andrea, Di Nanni, Noemi, Dourdoigne, Marion, Gavioli, Elena, Hattenberger, Marc, Heuser, Alisa, Hemmerlin, Christelle, Hinrichs, Jürgen, Kerr, Grainne, Laborde, Laurent, Jaco, Isabel, Núñez, Eloísa Jiménez, Martus, Hans-Joerg, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Schaeffer, Fanny, Schoepfer, Joseph, Schrapp, Maxime, Strang, Ross, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Zécri, Frédéric, Hofmann, Francesco, Möbitz, Henrik, Cortés-Cros, Marta

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Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors von Heuser, Alisa, Abdul Rahman, Wassim, Bechter, Elisabeth, Blank, Jutta, Buhr, Sylvia, Erdmann, Dirk, Fontana, Patrizia, Mermet‐Meillon, Fanny, Meyerhofer, Marco, Strang, Ross, Schrapp, Maxime, Zimmermann, Catherine, Cortes‐Cros, Marta, Möbitz, Henrik, Hamon, Jacques

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Structure-Based and Property-Driven Optimization of N‑Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors von Hoegenauer, Klemens, Kallen, Joerg, Jiménez-Núñez, Eloísa, Strang, Ross, Ertl, Peter, Cooke, Nigel G, Hintermann, Samuel, Voegtle, Markus, Betschart, Claudia, McKay, Daniel J. J, Wagner, Juergen, Ottl, Johannes, Beerli, Christian, Billich, Andreas, Dawson, Janet, Kaupmann, Klemens, Streiff, Markus, Gobeau, Nathalie, Harlfinger, Stephanie, Stringer, Rowan, Guntermann, Christine

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Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024) von Heuser, Alisa, Abdul Rahman, Wassim, Bechter, Elisabeth, Blank, Jutta, Buhr, Sylvia, Erdmann, Dirk, Fontana, Patrizia, Mermet‐Meillon, Fanny, Meyerhofer, Marco, Strang, Ross, Schrapp, Maxime, Zimmermann, Catherine, Cortes‐Cros, Marta, Möbitz, Henrik, Hamon, Jacques

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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability von Cortes-Cros, Marta, Moebitz, Henrik, Barbe, Stephanie, Blank, Jutta, Bordas, Vincent, Clementi, Giorgia, Dammassa, Ernesta, Decker, Andrea, Nanni, Noemi Di, de Kanter, Ruben, Dourdoigne, Marion, Gavioli, Elena, Ferretti, Stephane, Hattenberger, Marc, Hemmerlin, Christelle, Hamon, Jacques, Hinrichs, Juergen, Jaco, Isabel, Jankovic, Dragana, Nunez, Eloisa Jimenez, Li, Yifang, Martus, Hans-Joerg, Moschetta, Michele, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Scheufler, Clemens, Schoepfer, Joseph, Strang, Ross, Therier, Maxime, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Pham, Monica, Laborde, Laurent

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Orally bioavailable Syk inhibitors with activity in a rat PK/PD model von Thoma, Gebhard, Veenstra, Siem, Strang, Ross, Blanz, Joachim, Vangrevelinghe, Eric, Berghausen, Jörg, Lee, Christian C., Zerwes, Hans-Günter

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Inhalation by Design: Novel Tertiary Amine Muscarinic M 3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary... von Glossop, Paul A., Watson, Christine A. L., Price, David A., Bunnage, Mark E., Middleton, Donald S., Wood, Anthony, James, Kim, Roberts, Dannielle, Strang, Ross S., Yeadon, Michael, Perros-Huguet, Christelle, Clarke, Nicholas P., Trevethick, Michael A., Machin, Ian, Stuart, Emilio F., Evans, Steven M., Harrison, Anthony C., Fairman, David A., Agoram, Balaji, Burrows, Jane L., Feeder, Neil, Fulton, Craig K., Dillon, Barry R., Entwistle, David A., Spence, Fiona J.

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Inhalation by Design: Novel Tertiary Amine Muscarinic M3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary... von Glossop, Paul A, Watson, Christine A. L, Price, David A, Bunnage, Mark E, Middleton, Donald S, Wood, Anthony, James, Kim, Roberts, Dannielle, Strang, Ross S, Yeadon, Michael, Perros-Huguet, Christelle, Clarke, Nicholas P, Trevethick, Michael A, Machin, Ian, Stuart, Emilio F, Evans, Steven M, Harrison, Anthony C, Fairman, David A, Agoram, Balaji, Burrows, Jane L, Feeder, Neil, Fulton, Craig K, Dillon, Barry R, Entwistle, David A, Spence, Fiona J

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SOLID FORMS OF A FUSED PYRIDINE FOR THE TREAMTENT OF CANCER von WANG, Chang, MOEBITZ, Henrik, STRANG, Ross, SCHOEPFER, Joseph, HAMON, Jacques, BRUN, Jvan, PERLBERG, Anett, HONG, Ziyue, HINRICHS, Juergen Hans-Hermann

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BICYCLIC HETEROCYCLES AND THEIR USE AS WRN INHIBITORS von ZECRI, Frederic, MOEBITZ, Henrik, FUREGATI, Markus, NOCITO, Sandro, YU, Huangchao, GONG, Wanben, STRANG, Ross, SCHOEPFER, Joseph, HAMON, Jacques, SCHMIEDEBERG, Niko, HINRICHS, Juergen Hans-Hermann

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PHARMACEUTICAL COMBINATIONS AND USES THEREOF von FERRETTI, Stephane, MOEBITZ, Henrik, STRANG, Ross Sinclair, SCHOEPFER, Joseph, ANDRAOS-REY, Rita, BLUM-KALLERT, Sandra, JACO, Isabel Cristina Colaco Farias, LABORDE, Laurent, DE KANTER, Ruben, CORTES-CROS, Marta, MOSCHETTA, Michele, HAMON, Jacques, HINRICHS, Jürgen Hans-Hermann

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PHARMACEUTICAL COMBINATIONS AND USES THEREOF von FERRETTI, Stephane, MOEBITZ, Henrik, SCHOEPFER, Joseph, ANDRAOS-REY, Rita, BLUM-KALLERT, Sandra, LABORDE, Laurent, DE KANTER, Ruben, CORTES-CROS, Marta, STRANG, Ross, MOSCHETTA, Michele, HAMON, Jacques, HINRICHS, Juergen Hans-Hermann, JACO, Isabel Cristina

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Bicyclic compounds and their uses von Brun, Jvan, Furegati, Markus, Nocito, Sandro, Schoepfer, Joseph, Bordas, Vincent, Plattner, Simone, Zecri, Frédéric, Möbitz, Henrik, Strang, Ross Sinclair, Holzer, Philipp, Hinrichs, Jürgen Hans-Hermann, Hamon, Jacques, Limam, Fatma, Schmiedeberg, Niko

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Bicyclic Compounds and their Uses von ZHANG, Sisi, NOCITO, Sandro, GOGNIAT, Geoffrey, GONG, Wanben, SOTO, Jessica, STRANG, Ross Sinclair, HOLZER, Philipp, SCHOEPFER, Joseph, ZECRI, Frédéric, BORDAS, Vincent, FUREGATI, Markus, LIMAM, Fatma, YU, Huangchao, YAO, Shuping, HAMON, Jacques, BRUN, Jvan, SCHMIEDEBERG, Niko, MÖBITZ, Henrik, DECKER, Andrea, HINRICHS, Jürgen Hans-Hermann, PLATTNER, Simone

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