Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models von Challita-Eid, Pia M, Satpayev, Daulet, Yang, Peng, An, Zili, Morrison, Karen, Shostak, Yuriy, Raitano, Arthur, Nadell, Rossana, Liu, Wendy, Lortie, Dawn Ratay, Capo, Linnette, Verlinsky, Alla, Leavitt, Monica, Malik, Faisal, Aviña, Hector, Guevara, Claudia I, Dinh, Nick, Karki, Sher, Anand, Banmeet S, Pereira, Daniel S, Joseph, Ingrid B J, Doñate, Fernando, Morrison, Kendall, Stover, David R

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Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates von Zhao, Hui, Atkinson, John, Gulesserian, Sara, Zeng, Zhilan, Nater, Jenny, Ou, Jimmy, Yang, Peng, Morrison, Karen, Coleman, Jeffrey, Malik, Faisal, Challita-Eid, Pia, Karki, Sher, Aviña, Hector, Hubert, René, Capo, Linnette, Snyder, Josh, Moon, Sung-Ju, Luethy, Roland, Mendelsohn, Brian A, Stover, David R, Doñate, Fernando

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Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma von Fulciniti, Mariateresa, Tassone, Pierfrancesco, Hideshima, Teru, Vallet, Sonia, Nanjappa, Puru, Ettenberg, Seth A., Shen, Zhenxin, Patel, Nipun, Tai, Yu-tzu, Chauhan, Dharminder, Mitsiades, Constantine, Prabhala, Rao, Raje, Noopur, Anderson, Kenneth C., Stover, David R., Munshi, Nikhil C.

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Discoidin domain receptor 1 contributes to tumorigenesis through modulation of TGFBI expression von Rudra-Ganguly, Nandini, Lowe, Christine, Mattie, Michael, Chang, Mi Sook, Satpayev, Daulet, Verlinsky, Alla, An, Zili, Hu, Liping, Yang, Peng, Challita-Eid, Pia, Stover, David R, Pereira, Daniel S

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Inhibiting Dickkopf‐1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma von Heath, Deborah J, Chantry, Andrew D, Buckle, Clive H, Coulton, Les, Shaughnessy, John D, Evans, Holly R, Snowden, John A, Stover, David R, Vanderkerken, Karin, Croucher, Peter I

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Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia von Zhao, Hui, Gulesserian, Sara, Ganesan, Sathish Kumar, Ou, Jimmy, Morrison, Karen, Zeng, Zhilan, Robles, Veronica, Snyder, Josh, Do, Lisa, Aviña, Hector, Karki, Sher, Stover, David R, Doñate, Fernando

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A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise von Zhao, Hui, Gulesserian, Sara, Malinao, Maria Christina, Ganesan, Sathish Kumar, Song, James, Chang, Mi Sook, Williams, Melissa M, Zeng, Zhilan, Mattie, Michael, Mendelsohn, Brian A, Stover, David R, Doñate, Fernando

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The Discovery and Preclinical Development of ASG-5ME, an Antibody-Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer von Mattie, Michael, Raitano, Arthur, Morrison, Kendall, Morrison, Karen, An, Zili, Capo, Linnette, Verlinsky, Alla, Leavitt, Monica, Ou, Jimmy, Nadell, Rossana, Aviña, Hector, Guevara, Claudia, Malik, Faisal, Moser, Ruth, Duniho, Steven, Coleman, Jeffrey, Li, Ying, Pereira, Daniel S, Doñate, Fernando, Joseph, Ingrid B J, Challita-Eid, Pia, Benjamin, Dennis, Stover, David R

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Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker von Morrison, Kendall, Challita-Eid, Pia M, Raitano, Arthur, An, Zili, Yang, Peng, Abad, Joseph D, Liu, Wendy, Lortie, Dawn Ratay, Snyder, Josh T, Capo, Linnette, Verlinsky, Alla, Aviña, Hector, Doñate, Fernando, Joseph, Ingrid B J, Pereira, Daniel S, Morrison, Karen, Stover, David R

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AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML von Pereira, Daniel S, Guevara, Claudia I, Jin, Liqing, Mbong, Nathan, Verlinsky, Alla, Hsu, Ssucheng J, Aviña, Hector, Karki, Sher, Abad, Joseph D, Yang, Peng, Moon, Sung-Ju, Malik, Faisal, Choi, Michael Y, An, Zili, Morrison, Kendall, Challita-Eid, Pia M, Doñate, Fernando, Joseph, Ingrid B J, Kipps, Thomas J, Dick, John E, Stover, David R

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In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates von Jackson, Dowdy, Atkinson, John, Guevara, Claudia I, Zhang, Chunying, Kery, Vladimir, Moon, Sung-Ju, Virata, Cyrus, Yang, Peng, Lowe, Christine, Pinkstaff, Jason, Cho, Ho, Knudsen, Nick, Manibusan, Anthony, Tian, Feng, Sun, Ying, Lu, Yingchun, Sellers, Aaron, Jia, Xiao-Chi, Joseph, Ingrid, Anand, Banmeet, Morrison, Kendall, Pereira, Daniel S, Stover, David

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1159 A targeted masked ImmunoCytokine for CD138 expressing cancers von Trinh, Ryan, Vasuthasawat, Alex, Morrison, Sherie L, Stover, David

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Molecular Characterization of Patient-Derived Human Pancreatic Tumor Xenograft Models for Preclinical and Translational Development of Cancer Therapeutics von Mattie, Mike, Christensen, Ashley, Chang, Mi Sook, Yeh, William, Said, Suzanne, Shostak, Yuriy, Capo, Linnette, Verlinsky, Alla, An, Zili, Joseph, Ingrid, Zhang, Yi, Kumar-Ganesan, Sathish, Morrison, Karen, Stover, David, Challita-Eid, Pia

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AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma von Doñate, Fernando, Raitano, Arthur, Morrison, Kendall, An, Zili, Capo, Linnette, Aviña, Hector, Karki, Sher, Morrison, Karen, Yang, Peng, Ou, Jimmy, Moriya, Ryuichi, Shostak, Yuriy, Malik, Faisal, Nadell, Rossana, Liu, Wendy, Satpayev, Daulet, Atkinson, John, Joseph, Ingrid B J, Pereira, Daniel S, Challita-Eid, Pia M, Stover, David R

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies von Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng, Nusse, Roeland

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Abstract 3853: Potential mechanisms for thrombocytopenia and neutropenia induced by antibody-drug conjugates von Zhao, Hui, Gulesserian, Sara, Ganesan, Sathish K., Zeng, Zhilan, Ou, Jimmy, Robles, Veronica, Snyder, Josh, Stover, David R., Donate, Fernando

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Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates von Jackson, Dowdy, Stover, David

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Preclinical Evaluation of an Anti-Nectin-4 ImmunoPET Reagent in Tumor-Bearing Mice and Biodistribution Studies in Cynomolgus Monkeys von Campbell, Dean O., Noda, Akihiro, Verlinsky, Alla, Snyder, Josh, Fujita, Yuji, Murakami, Yoshihiro, Fushiki, Hiroshi, Miyoshi, Sosuke, Lacayo, Sergio, Cabral, Edward, Yang, Peng, Stover, David R., Joseph, Ingrid B. J .K.

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Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors von Zhu, Xiaotian, Kim, Joseph L, Newcomb, John R, Rose, Paul E, Stover, David R, Toledo, Leticia M, Zhao, Huilin, Morgenstern, Kurt A

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Abstract 574: AGS62P1, a novel site-specific antibody drug conjugate targeting FLT3 exhibits potent anti-tumor activity regardless of FLT3 kinase activation status von Rudra-Ganguly, Nandini, Challita-Eid, Pia M., Lowe, Christine, Mattie, Mike, Moon, Sung-Ju, Mendelsohn, Brian A., Leavitt, Monica, Virata, Cyrus, Verlinsky, Alla, Capo, Linnette, Chang, Mi Sook, Russell, Deanna L., Randhawa, Baljinder, Liu, Gao, Hubert, René, Brodey, Mary, Aviña, Hector, Zhang, Chunying, Abad, Joseph D., Anand, Banmeet, Karki, Sher, An, Zili, Luethy, Roland, Doñate, Fernando, Pereira, Daniel S., Morrison, Kendall, Joseph, Ingrid B.J., Stover, David R.

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