A Bayesian machine learning approach for drug target identification using diverse data types von Madhukar, Neel S., Khade, Prashant K., Huang, Linda, Gayvert, Kaitlyn, Galletti, Giuseppe, Stogniew, Martin, Allen, Joshua E., Giannakakou, Paraskevi, Elemento, Olivier

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Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia von Nii, Takenobu, Prabhu, Varun V., Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E., Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael

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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality von Ishizawa, Jo, Zarabi, Sarah F., Davis, R. Eric, Halgas, Ondrej, Nii, Takenobu, Jitkova, Yulia, Zhao, Ran, St-Germain, Jonathan, Heese, Lauren E., Egan, Grace, Ruvolo, Vivian R., Barghout, Samir H., Nishida, Yuki, Hurren, Rose, Ma, Wencai, Gronda, Marcela, Link, Todd, Wong, Keith, Mabanglo, Mark, Kojima, Kensuke, Borthakur, Gautam, MacLean, Neil, Ma, Man Chun John, Leber, Andrew B., Minden, Mark D., Houry, Walid, Kantarjian, Hagop, Stogniew, Martin, Raught, Brian, Pai, Emil F., Schimmer, Aaron D., Andreeff, Michael

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ONC201 and imipridones: Anti-cancer compounds with clinical efficacy von Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.

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First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors von Stein, Mark N, Bertino, Joseph R, Kaufman, Howard L, Mayer, Tina, Moss, Rebecca, Silk, Ann, Chan, Nancy, Malhotra, Jyoti, Rodriguez, Lorna, Aisner, Joseph, Aiken, Robert D, Haffty, Bruce G, DiPaola, Robert S, Saunders, Tracie, Zloza, Andrew, Damare, Sherri, Beckett, Yasmeen, Yu, Bangning, Najmi, Saltanat, Gabel, Christian, Dickerson, Siobhan, Zheng, Ling, El-Deiry, Wafik S, Allen, Joshua E, Stogniew, Martin, Oster, Wolfgang, Mehnert, Janice M

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Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA von Warner-Schmidt, Jennifer, Stogniew, Martin, Mandell, Blake, Rowland, R Scott, Schmidt, Eric F, Kelmendi, Benjamin

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Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212 von Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D, Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L, Nallaganchu, Bhaskara Rao, Benes, Cyril H, Allen, Joshua E, Prabhu, Varun V, Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S

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Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

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Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity von Warner-Schmidt, Jennifer, Pittenger, Christopher, Stogniew, Martin, Mandell, Blake, Olmstead, Sarah J, Kelmendi, Benjamin

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Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration von Stein, Mark N, Malhotra, Jyoti, Tarapore, Rohinton S, Malhotra, Usha, Silk, Ann W, Chan, Nancy, Rodriguez, Lorna, Aisner, Joseph, Aiken, Robert D, Mayer, Tina, Haffty, Bruce G, Newman, Jenna H, Aspromonte, Salvatore M, Bommareddy, Praveen K, Estupinian, Ricardo, Chesson, Charles B, Sadimin, Evita T, Li, Shengguo, Medina, Daniel J, Saunders, Tracie, Frankel, Melissa, Kareddula, Aparna, Damare, Sherrie, Wesolowsky, Elayne, Gabel, Christian, El-Deiry, Wafik S, Prabhu, Varun V, Allen, Joshua E, Stogniew, Martin, Oster, Wolfgang, Bertino, Joseph R, Libutti, Steven K, Mehnert, Janice M, Zloza, Andrew

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Pharmacokinetics and Tissue Distribution of Anidulafungin in Rats von DAMLE, Bharat, STOGNIEW, Martin, DOWELL, James

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In Vitro and In Vivo Studies To Characterize the Clearance Mechanism and Potential Cytochrome P450 Interactions of Anidulafungin von DAMLE, Bharat D, DOWELL, James A, WALSKY, Robert L, WEBER, Gregory L, STOGNIEW, Martin, INSKEEP, Philip B

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Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201 von Chi, Andrew S., Tarapore, Rohinton S., Hall, Matthew D., Shonka, Nicole, Gardner, Sharon, Umemura, Yoshie, Sumrall, Ashley, Khatib, Ziad, Mueller, Sabine, Kline, Cassie, Zaky, Wafik, Khatua, Soumen, Weathers, Shiao-Pei, Odia, Yazmin, Niazi, Toba N., Daghistani, Doured, Cherrick, Irene, Korones, David, Karajannis, Matthias A., Kong, Xiao-Tang, Minturn, Jane, Waanders, Angela, Arillaga-Romany, Isabel, Batchelor, Tracy, Wen, Patrick Y., Merdinger, Krystal, Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, Mehta, Minesh P.

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Biological activity of weekly ONC201 in adult recurrent glioblastoma patients von Arrillaga-Romany, Isabel, Odia, Yazmin, Prabhu, Varun V, Tarapore, Rohinton S, Merdinger, Krystal, Stogniew, Martin, Oster, Wolfgang, Allen, Joshua E, Mehta, Minesh, Batchelor, Tracy T, Wen, Patrick Y

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Abstract 1370: ADME and toxicology profiles of first-in-class DRD2/ClpP-targeted imipridone ONC201 von Morrow, Sara, Tarapore, Rohinton, Guo, Ailan, Nej, Magdalena, Fang, Yunlan, Theerman, Gina, Lake, Leah, Stogniew, Martin, Prabhu, Varun V., Allen, Joshua E.

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Anidulafungin Does Not Require Dosage Adjustment in Subjects With Varying Degrees of Hepatic or Renal Impairment von Dowell, James A., Stogniew, Martin, Krause, David, Damle, Bharat

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EXTH-77. ONC201 EXHIBITS PASSIVE DIFFUSION AND BROAD DISTRIBUTION IN THE CENTRAL NERVOUS SYSTEM von Morrow, Sara, Prabhu, Varun, Tarapore, Rohinton S, Theerman, Gina, Lake, Leah, Guo, Ailan, Stogniew, Martin, Allen, Joshua

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EXTH-70. CYP450 AND METABOLIC PROFILING OF ANTI-CANCER IMIPRIDONE ONC201 von Morrow, Sara, Prabhu, Varun, Tarapore, Rohinton S, Guo, Ailan, Fang, Yunlan, Nej, Magdalena, Stogniew, Martin, Allen, Joshua

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First-in-human dose escalation and food effect study of oral ONC206 in adults with recurrent primary CNS neoplasms von Theeler, Brett James, Jung, Jinkyu, Burton, Eric, Leeper, Heather, Wu, Jing, Zaghloul, Kareem, Ray-Chaudhury, Abhik, Quezado, Martha, Raffeld, Mark, Yuan, Ying, Aldape, Kenneth D., Penas-Prado, Marta, Prabhu, Varun Vijay, Stogniew, Martin, Allen, Joshua E., Armstrong, Terri S., Gilbert, Mark R.

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Abstract 3245: Preclinical evaluation of the imipridone family of small molecules, including analogues of clinical-stage anti-cancer small molecule ONC201, reveals potent anti-canc... von Wagner, Jessica, Kline, C. Leah, Olson, Gary, Nallaganchu, Bhaskara, Pottorf, Richard, Prabhu, Varun, Stogniew, Martin, Allen, Joshua, El-Deiry, Wafik

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