Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) von Pidathala, Chandrakala, Amewu, Richard, Pacorel, Bénédicte, Nixon, Gemma L, Gibbons, Peter, Hong, W. David, Leung, Suet C, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M

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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs von Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.

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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 c... von Chadwick, James, Jones, Michael, Mercer, Amy E., Stocks, Paul A., Ward, Stephen A., Park, B. Kevin, O’Neill, Paul M.

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Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex von Biagini, Giancarlo A, Fisher, Nicholas, Berry, Neil, Stocks, Paul A, Meunier, Brigitte, Williams, Dominic P, Bonar-Law, Richard, Bray, Patrick G, Owen, Andrew, O'Neill, Paul M, Ward, Stephen A

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Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century von O’Neill, Paul M, Park, B. Kevin, Shone, Alison E, Maggs, James L, Roberts, Phillip, Stocks, Paul A, Biagini, Giancarlo A, Bray, Patrick G, Gibbons, Peter, Berry, Neil, Winstanley, Peter A, Mukhtar, Amira, Bonar-Law, Richard, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Hart, Timothy K, Gresham, Stephanie L, Lawrence, Ron M, Brigandi, Richard A, Gomez-delas-Heras, Federico M, Gargallo, Domingo V, Ward, Stephen A

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PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX von Bray, Patrick G., Mungthin, Mathirut, Hastings, Ian M., Biagini, Giancarlo A., Saidu, Dauda K., Lakshmanan, Viswanathan, Johnson, David J., Hughes, Ruth H., Stocks, Paul A., O'Neill, Paul M., Fidock, David A., Warhurst, David C., Ward, Stephen A.

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Antitumour and antimalarial activity of artemisinin-acridine hybrids von JONES, Michael, MERCER, Amy E, BRAY, Patrick G, RAWE, Sarah L, BAIRD, Jonathan, CHARIDZA, Tafadzwa, JANNEH, Omar, O'NEILL, Paul M, STOCKS, Paul A, LA PENSEE, Louise J. I, COSSTICK, Rick, PARK, B. Kevin, KENNEDY, Miriam E, PIANTANIDA, Ivo, WARD, Stephen A, DAVIES, Jill

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Application of Thiol−Olefin Co-oxygenation Methodology to a New Synthesis of the 1,2,4-Trioxane Pharmacophore von O'Neill, Paul M, Mukhtar, Amira, Ward, Stephen A, Bickley, Jamie F, Davies, Jill, Bachi, Mario D, Stocks, Paul A

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Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis von Hong, W. David, Gibbons, Peter D, Leung, Suet C, Amewu, Richard, Stocks, Paul A, Stachulski, Andrew, Horta, Pedro, Cristiano, Maria L. S, Shone, Alison E, Moss, Darren, Ardrey, Alison, Sharma, Raman, Warman, Ashley J, Bedingfield, Paul T. P, Fisher, Nicholas E, Aljayyoussi, Ghaith, Mead, Sally, Caws, Maxine, Berry, Neil G, Ward, Stephen A, Biagini, Giancarlo A, O’Neill, Paul M, Nixon, Gemma L

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Design and Synthesis of Endoperoxide Antimalarial Prodrug Models von O'Neill, Paul M., Stocks, Paul A., Pugh, Matthew D., Araujo, Nuna C., Korshin, Edward E., Bickley, Jamie F., Ward, Stephen A., Bray, Patrick G., Pasini, Erica, Davies, Jill, Verissimo, Edite, Bachi, Mario D.

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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria von Biagini, Giancarlo A, Fisher, Nicholas, Shone, Alison E, Mubaraki, Murad A, Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A, Nixon, Gemma L, Chadwick, James, Hemingway, Janet, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H. M, Berry, Neil G, O’Neill, Paul M, Ward, Stephen A

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Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria von O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Jiménez-Díaz, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.

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Glutathione transport: a new role for PfCRT in chloroquine resistance von Patzewitz, Eva-Maria, Salcedo-Sora, J Enrique, Wong, Eleanor H, Sethia, Sonal, Stocks, Paul A, Maughan, Spencer C, Murray, James A H, Krishna, Sanjeev, Bray, Patrick G, Ward, Stephen A, Müller, Sylke

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Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) von Leung, Suet C, Gibbons, Peter, Amewu, Richard, Nixon, Gemma L, Pidathala, Chandrakala, Hong, W. David, Pacorel, Bénédicte, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M

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The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters von Salcedo-Sora, J Enrique, Ochong, Edwin, Beveridge, Susan, Johnson, David, Nzila, Alexis, Biagini, Giancarlo A, Stocks, Paul A, O'Neill, Paul M, Krishna, Sanjeev, Bray, Patrick G, Ward, Stephen A

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Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles von Ellis, Gemma L, Amewu, Richard, Sabbani, Sunil, Stocks, Paul A, Shone, Alison, Stanford, Deborah, Gibbons, Peter, Davies, Jill, Vivas, Livia, Charnaud, Sarah, Bongard, Emily, Hall, Charlotte, Rimmer, Karen, Lozanom, Sonia, Jesús, María, Gargallo, Domingo, Ward, Stephen A, O’Neill, Paul M

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Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines : synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates von ARAUJO, Nuna C. P, BARTON, Victoria, JONES, Michael, STOCKS, Paul A, WARD, Stephen A, DAVIES, Jill, BRAY, Patrick G, SHONE, Alison E, CRISTIANO, Maria L. S, O'NEILL, Paul M

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Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity von Gibbons, Peter, Verissimo, Edite, Araujo, Nuna C, Barton, Victoria, Nixon, Gemma L, Amewu, Richard K, Chadwick, James, Stocks, Paul A, Biagini, Giancarlo A, Srivastava, Abhishek, Rosenthal, Philip J, Gut, Jiri, Guedes, Rita C, Moreira, Rui, Sharma, Raman, Berry, Neil, Cristiano, M. Lurdes S, Shone, Alison E, Ward, Stephen A, O’Neill, Paul M

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New 4-Aminoquinoline Mannich Base Antimalarials. 1. Effect of an Alkyl Substituent in the 5‘-Position of the 4‘-Hydroxyanilino Side Chain von Raynes, Kaylene J, Stocks, Paul A, O'Neill, Paul M, Park, B. Kevin, Ward, Stephen A

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Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compoun... von O’Neill, Paul M, Shone, Alison E, Stanford, Deborah, Nixon, Gemma, Asadollahy, Eghbaleh, Park, B. Kevin, Maggs, James L, Roberts, Phil, Stocks, Paul A, Biagini, Giancarlo, Bray, Patrick G, Davies, Jill, Berry, Neil, Hall, Charlotte, Rimmer, Karen, Winstanley, Peter A, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Gresham, Stephanie L, Brigandi, Richard A, Gomez-de-las-Heras, Federico M, Gargallo, Domingo V, Parapini, Silvia, Vivas, Livia, Lander, Hollie, Taramelli, Donatella, Ward, Stephen A

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