Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity von Chamberlain, Stanley D, Redman, Anikó M, Wilson, Joseph W, Deanda, Felix, Shotwell, J Brad, Gerding, Roseanne, Lei, Huangshu, Yang, Bin, Stevens, Kirk L, Hassell, Anne M, Shewchuk, Lisa M, Leesnitzer, M Anthony, Smith, Jeffery L, Sabbatini, Peter, Atkins, Charity, Groy, Arthur, Rowand, Jason L, Kumar, Rakesh, Mook, Jr, Robert A, Moorthy, Ganesh, Patnaik, Samarjit

Volltext

Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors von Waterson, Alex G., Petrov, Kimberly G., Hornberger, Keith R., Hubbard, Robert D., Sammond, Douglas M., Smith, Stephon C., Dickson, Hamilton D., Caferro, Thomas R., Hinkle, Kevin W., Stevens, Kirk L., Dickerson, Scott H., Rusnak, David W., Spehar, Glenn M., Wood, Edgar R., Griffin, Robert J., Uehling, David E.

Volltext

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors von Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Haran, Aaron C, Ip, Carmen, Kaplan, Joshua A, Kim, Musong, Koditek, David, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Novikov, Nikolai, Perreault, Stephane, Puri, Kamal D, Somoza, John R, Steiner, Bart H, Stevens, Kirk L, Therrien, Joseph, Treiberg, Jennifer, Villaseñor, Armando G, Yeung, Arthur, Phillips, Gary

Volltext

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors von Stevens, Kirk L., Alligood, Krystal J., Alberti, Jennifer G. Badiang, Caferro, Thomas R., Chamberlain, Stanley D., Dickerson, Scott H., Dickson, Hamilton D., Emerson, Holly K., Griffin, Robert J., Hubbard, Robert D., Keith, Barry R., Mullin, Robert J., Petrov, Kimberly G., Gerding, Roseanne M., Reno, Michael J., Rheault, Tara R., Rusnak, David W., Sammond, Douglas M., Smith, Stephon C., Uehling, David E., Waterson, Alex G., Wood, Edgar R.

Volltext

Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors von Stevens, Kirk L, Jung, David K, Alberti, Michael J, Badiang, Jennifer G, Peckham, Gregory E, Veal, Jim M, Cheung, Mui, Harris, Philip A, Chamberlain, Stanley D, Peel, Michael R

Volltext

Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase von Patnaik, Samarjit, Stevens, Kirk L., Gerding, Roseanne, Deanda, Felix, Shotwell, J. Brad, Tang, Jun, Hamajima, Toshihiro, Nakamura, Hiroko, Leesnitzer, M. Anthony, Hassell, Anne M., Shewchuck, Lisa M., Kumar, Rakesh, Lei, Huangshu, Chamberlain, Stanley D.

Volltext

Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors von Stevens, Kirk L., Reno, Michael J., Alberti, Jennifer B., Price, Daniel J., Kane-Carson, Laurie S., Knick, Victoria B., Shewchuk, Lisa M., Hassell, Anne M., Veal, James M., Davis, Stephen T., Griffin, Robert J., Peel, Michael R.

Volltext

Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) von Emmitte, Kyle A., Wilson, Brian J., Baum, Erich W., Emerson, Holly K., Kuntz, Kevin W., Nailor, Kristen E., Salovich, James M., Smith, Stephon C., Cheung, Mui, Gerding, Roseanne M., Stevens, Kirk L., Uehling, David E., Mook, Robert A., Moorthy, Ganesh S., Dickerson, Scott H., Hassell, Anne M., Anthony Leesnitzer, M., Shewchuk, Lisa M., Groy, Arthur, Rowand, Jason L., Anderson, Kelly, Atkins, Charity L., Yang, Jingsong, Sabbatini, Peter, Kumar, Rakesh

Volltext

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase von CHAMBERLAIN, Stanley D, WILSON, Joseph W, ATKINS, Charity, GERDING, Roseanne, HASSELL, Anne M, HUANGSHU LEI, MOCK, Robert A, MOORTHY, Ganesh, ROWAND, Jason L, STEVENS, Kirk L, KUMAR, Rakesh, BRAD SHOTWELL, J, DEANDA, Felix, PATNAIK, Samarjit, REDMAN, Aniko M, BIN YANG, SHEWCHUK, Lisa, SABBATINI, Peter, LEESNITZER, M. Anthony, GROY, Arthur

Volltext

Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway von CHAMBERLAIN, Stanley D, REDMAN, Aniko M, STEVENS, Kirk L, WILSON, Joseph W, BRAD SHOTWELL, J, PATNAIK, Samarjit, BRICKHOUSE, Keith, CHEW, Yen-Chiat, DEANDA, Felix, GERDING, Roseanne, HUANGSHU LEI, MOORTHY, Ganesh, PATRICK, Mark

Volltext

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines von Chamberlain, Stanley D, Gerding, Roseanne M, Lei, Huangshu, Moorthy, Ganesh, Patnaik, Samarjit, Redman, Anikó M, Stevens, Kirk L, Wilson, Joseph W, Yang, Bin, Shotwell, J. Brad

Volltext

Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors von Waterson, Alex G., Stevens, Kirk L., Reno, Michael J., Zhang, Yue-Mei, Boros, Eric E., Bouvier, Frederic, Rastagar, Abdullah, Uehling, David E., Dickerson, Scott H., Reep, Bryan, McDonald, Octerloney B., Wood, Edgar R., Rusnak, David W., Alligood, Krystal J., Rudolph, Sharon K.

Volltext

A Convergent Approach to Coenzyme Q von Lipshutz, Bruce H, Bulow, Gerd, Fernandez-Lazaro, Fernando, Kim, Sung-Kyu, Lowe, Richard, Mollard, Paul, Stevens, Kirk L

Volltext

Allylated aromatics via Ni-catalyzed couplings of benzylic chlorides and vinylic organometallics von Lipshutz, Bruce H., Bülow, Gerd, Lowe, Richard F., Stevens, Kirk L.

Volltext

An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis von Lipshutz, Bruce H., Kim, Sung-kyu, Mollard, Paul, Stevens, Kirk L.

Volltext

A Novel Route to Coenzyme Q n von Lipshutz, Bruce H, Bulow, Gerd, Lowe, Richard F, Stevens, Kirk L

Volltext

SYNTHESIS OF PYRAZOLO[1,5-a]PYRIDINES VIA AZIRINES: PREPARATION OF 2-(3-BROMOPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-a]PYRIDINE

Volltext

Total Synthesis of Altohyrtin A (Spongistatin 1): Part 2 von Hayward, Matthew M., Roth, Rebecca M., Duffy, Kevin J., Dalko, Peter I., Stevens, Kirk L., Guo, Jiasheng, Kishi, Yoshito

Volltext

Total Synthesis of Altohyrtin A (Spongistatin 1): Part 1 von Guo, Jiasheng, Duffy, Kevin J., Stevens, Kirk L., Dalko, Peter I., Roth, Rebecca M., Hayward, Matthew M., Kishi, Yoshito

Volltext

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines von Chamberlain, Stanley D., Gerding, Roseanne M., Lei, Huangshu, Moorthy, Ganesh, Patnaik, Samarjit, Redman, Anikó M., Stevens, Kirk L., Wilson, Joseph W., Yang, Bin, Shotwell, J. Brad

Volltext