Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties von Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Bhakta, Sunil, Blaquiere, Nicole, Chen, Jinhua, dela Cruz-Chuh, Josefa, Gascoigne, Karen E, Hartman, Steven J, He, Mingtao, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liang, Liu, Liling, Liu, Qi, Lu, Ying, Meng, Fanwei, Mulvihill, Melinda M, O’Donohue, Aimee, Rowntree, Rebecca K, Staben, Leanna R, Staben, Steven T, Wai, John, Wang, Jian, Wei, BinQing, Wilson, Catherine, Xin, Jianfeng, Xu, Zijin, Yao, Hui, Zhang, Donglu, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu

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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition von Vande Walle, Lieselotte, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

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Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide... von McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.

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Four-Component Synthesis of Fully Substituted 1,2,4-Triazoles von Staben, Steven T, Blaquiere, Nicole

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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus von Brightbill, Hans D., Suto, Eric, Blaquiere, Nicole, Ramamoorthi, Nandhini, Sujatha-Bhaskar, Swathi, Gogol, Emily B., Castanedo, Georgette M., Jackson, Benjamin T., Kwon, Youngsu C., Haller, Susan, Lesch, Justin, Bents, Karin, Everett, Christine, Kohli, Pawan Bir, Linge, Sandra, Christian, Laura, Barrett, Kathy, Jaochico, Allan, Berezhkovskiy, Leonid M., Fan, Peter W., Modrusan, Zora, Veliz, Kelli, Townsend, Michael J., DeVoss, Jason, Johnson, Adam R., Godemann, Robert, Lee, Wyne P., Austin, Cary D., McKenzie, Brent S., Hackney, Jason A., Crawford, James J., Staben, Steven T., Alaoui Ismaili, Moulay H., Wu, Lawren C., Ghilardi, Nico

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Gold(I)-Catalyzed Stereoselective Olefin Cyclopropanation von Johansson, Magnus J, Gorin, David J, Staben, Steven T, Toste, F. Dean

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Au(I)-Catalyzed Ring Expanding Cycloisomerizations: Total Synthesis of Ventricosene von Sethofer, Steven G, Staben, Steven T, Hung, Olivia Y, Toste, F. Dean

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Gold(I)-Catalyzed Ring Expansion of Cyclopropanols and Cyclobutanols von Markham, Jordan P, Staben, Steven T, Toste, F. Dean

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Gold(I)-Catalyzed Cyclizations of Silyl Enol Ethers: Application to the Synthesis of (+)-Lycopladine A von Staben, Steven T., Kennedy-Smith, Joshua J., Huang, David, Corkey, Britton K., LaLonde, Rebecca L., Toste, F. Dean

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The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site von de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.

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Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition von Walle, Lieselotte Vande, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubr, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

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Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases von Blaquiere, Nicole, Villemure, Elisia, Staben, Steven T

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Monomeric Targeted Protein Degraders von Hanan, Emily J, Liang, Jun, Wang, Xiaojing, Blake, Robert A, Blaquiere, Nicole, Staben, Steven T

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Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study von Yamazoe, Sayumi, Tom, Jeffrey, Fu, Yue, Wu, Wenqiong, Zeng, Liang, Sun, Changlei, Liu, Qi, Lin, Jie, Lin, Kui, Fairbrother, Wayne J, Staben, Steven T

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Selective activation of PFKL suppresses the phagocytic oxidative burst von Amara, Neri, Cooper, Madison P., Voronkova, Maria A., Webb, Bradley A., Lynch, Eric M., Kollman, Justin M., Ma, Taylur, Yu, Kebing, Lai, Zijuan, Sangaraju, Dewakar, Kayagaki, Nobuhiko, Newton, Kim, Bogyo, Matthew, Staben, Steven T., Dixit, Vishva M.

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A General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling von Schempp, Tabitha T, Daniels, Blake E, Staben, Steven T, Stivala, Craig E

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα) von Dragovich, Peter S., Adhikari, Pragya, Blake, Robert A., Blaquiere, Nicole, Chen, Jinhua, Cheng, Yun-Xing, den Besten, Willem, Han, Jinping, Hartman, Steven J., He, Jintang, He, Mingtao, Rei Ingalla, Ellen, Kamath, Amrita V., Kleinheinz, Tracy, Lai, Tommy, Leipold, Douglas D., Li, Chun Sing, Liu, Qi, Lu, Jiawei, Lu, Ying, Meng, Fanwei, Meng, Lingyao, Ng, Carl, Peng, Kaishan, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sadowsky, Jack D., Sampath, Deepak, Staben, Leanna, Staben, Steven T., Wai, John, Wan, Kunpeng, Wang, Xinxin, Wei, BinQing, Wertz, Ingrid E., Xin, Jianfeng, Xu, Keyang, Yao, Hui, Zang, Richard, Zhang, Donglu, Zhou, Hao, Zhao, Yongxin

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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα von Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.

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Targeted degradation via direct 26S proteasome recruitment von Bashore, Charlene, Prakash, Sumit, Johnson, Matthew C., Conrad, Ryan J., Kekessie, Ivy A., Scales, Suzie J., Ishisoko, Noriko, Kleinheinz, Tracy, Liu, Peter S., Popovych, Nataliya, Wecksler, Aaron T., Zhou, Lijuan, Tam, Christine, Zilberleyb, Inna, Srinivasan, Rajini, Blake, Robert A., Song, Aimin, Staben, Steven T., Zhang, Yingnan, Arnott, David, Fairbrother, Wayne J., Foster, Scott A., Wertz, Ingrid E., Ciferri, Claudio, Dueber, Erin C.

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Identifying transcriptional programs underlying cancer drug response with TraCe-seq von Chang, Matthew T., Shanahan, Frances, Nguyen, Thi Thu Thao, Staben, Steven T., Gazzard, Lewis, Yamazoe, Sayumi, Wertz, Ingrid E., Piskol, Robert, Yang, Yeqing Angela, Modrusan, Zora, Haley, Benjamin, Evangelista, Marie, Malek, Shiva, Foster, Scott A., Ye, Xin

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