Immunogenicity to Biotherapeutics - The Role of Anti-drug Immune Complexes von Krishna, Murli, Nadler, Steven G

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Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis von Cutolo, Maurizio, Nadler, Steven G

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clinical utility of inhibiting CD28-mediated costimulation von Linsley, Peter S, Nadler, Steven G

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Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer von Manjarrez-Orduño, Nataly, Menard, Laurence C, Kansal, Selena, Fischer, Paul, Kakrecha, Bijal, Jiang, Can, Cunningham, Mark, Greenawalt, Danielle, Patel, Vishal, Yang, Minghui, Golhar, Ryan, Carman, Julie A, Lezhnin, Sergey, Dai, Hongyue, Kayne, Paul S, Suchard, Suzanne J, Bernstein, Steven H, Nadler, Steven G

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Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers von Menard, Laurence C, Fischer, Paul, Kakrecha, Bijal, Linsley, Peter S, Wambre, Erik, Liu, Maochang C, Rust, Blake J, Lee, Deborah, Penhallow, Becky, Manjarrez Orduno, Nataly, Nadler, Steven G

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A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety von Suchard, Suzanne J, Davis, Patricia M, Kansal, Selena, Stetsko, Dawn K, Brosius, Ruth, Tamura, James, Schneeweis, Lumelle, Bryson, James, Salcedo, Theodora, Wang, Haiqing, Yang, Zheng, Fleener, Catherine A, Ignatovich, Olga, Plummer, Christopher, Grant, Steven, Nadler, Steven G

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope von Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven

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Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699 von Yang, Zheng, Wang, Haiqing, Salcedo, Theodora W., Suchard, Suzanne J., Xie, Jenny H., Schneeweis, Lumelle A., Fleener, Catherine A., Calore, James D., Shi, Rong, Zhang, Sean X.Y., Rodrigues, A. David, Car, Bruce D., Marathe, Punit H., Nadler, Steven G.

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Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan... von Weinstein, David S, Gong, Hua, Doweyko, Arthur M, Cunningham, Mark, Habte, Sium, Wang, Jin Hong, Holloway, Deborah A, Burke, Christine, Gao, Ling, Guarino, Victor, Carman, Julie, Somerville, John E, Shuster, David, Salter-Cid, Luisa, Dodd, John H, Nadler, Steven G, Barrish, Joel C

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CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis von Zhang, Hui, Watanabe, Ryu, Berry, Gerald J., Nadler, Steven G., Goronzy, Jörg J., Weyand, Cornelia M.

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A novel CD71 Centyrin:Gys1 siRNA conjugate reduces glycogen synthesis and glycogen levels in a mouse model of Pompe disease von Holt, Bryce D, Elliott, Samuel J, Meyer, Rebecca, Reyes, Daniela, O'Neil, Karyn, Druzina, Zhanna, Kulkarni, Swapnil, Thurberg, Beth L, Nadler, Steven G, Pederson, Bartholomew A

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Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators von Xiao, Hai-Yun, Wu, Dauh-Rurng, Malley, Mary F, Gougoutas, Jack Z, Habte, Sium F, Cunningham, Mark D, Somerville, John E, Dodd, John H, Barrish, Joel C, Nadler, Steven G, Dhar, T. G. Murali

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2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses von Liu, Danya, Krummey, Scott M, Badell, I Raul, Wagener, Maylene, Schneeweis, Lumelle A, Stetsko, Dawn K, Suchard, Suzanne J, Nadler, Steven G, Ford, Mandy L

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Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids von Hu, Yanhua, Carman, Julie A., Holloway, Deborah, Kansal, Selena, Fan, Li, Goldstine, Christine, Lee, Deborah, Somerville, John E., Latek, Robert, Townsend, Robert, Johnsen, Alyssa, Connolly, Sean, Bandyopadhyay, Somnath, Shadick, Nancy, Weinblatt, Michael E., Furie, Richard, Nadler, Steven G.

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Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells von Platt, Andrew M, Gibson, Vivienne B, Patakas, Agapitos, Benson, Robert A, Nadler, Steven G, Brewer, James M, McInnes, Iain B, Garside, Paul

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Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen‐Presenting Cells von Patakas, Agapitos, Ji, Rui‐Ru, Weir, William, Connolly, Sean E., Benson, Robert A., Nadler, Steven G., Brewer, James M., McInnes, Iain B., Garside, Paul

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CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis von Tang, Anita L, Teijaro, John R, Njau, Modesta N, Chandran, Smita S, Azimzadeh, Agnes, Nadler, Steven G, Rothstein, David M, Farber, Donna L

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Control of Memory CD4 T Cell Recall by the CD28/B7 Costimulatory Pathway von Ndejembi, Modesta P, Teijaro, John R, Patke, Deepa S, Bingaman, Adam W, Chandok, Meena R, Azimzadeh, Agnes, Nadler, Steven G, Farber, Donna L

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Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors von Hynes, John, Wu, Hong, Kempson, James, Duan, James J.-W., Lu, Zhonghui, Jiang, Bin, Stachura, Sylwia, Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan S., Zhang, Rosemary F., Pitt, Sidney, Shen, Guoxiang, Gillooly, Kate, McIntyre, Kim, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Fura, Aberra, Schieven, Gary L., Pitts, William J., Wrobleski, Stephen T.

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Costimulation Modulation Uncouples Protection from Immunopathology in Memory T Cell Responses to Influenza Virus von Teijaro, John R, Njau, Modesta N, Verhoeven, David, Chandran, Smita, Nadler, Steven G, Hasday, Jeffrey, Farber, Donna L

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