The PPARs:  From Orphan Receptors to Drug Discovery von Willson, Timothy M, Brown, Peter J, Sternbach, Daniel D, Henke, Brad R

Volltext

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors von Xu, H.Eric, Lambert, Millard H, Montana, Valerie G, Parks, Derek J, Blanchard, Steven G, Brown, Peter J, Sternbach, Daniel D, Lehmann, Jürgen M, Wisely, G.Bruce, Willson, Timothy M, Kliewer, Steven A, Milburn, Michael V

Volltext

A Selective Peroxisome Proliferator-Activated Receptor δ Agonist Promotes Reverse Cholesterol Transport von Oliver, William R., Shenk, Jennifer L., Snaith, Mike R., Russell, Caroline S., Plunket, Kelli D., Bodkin, Noni L., Lewis, Michael C., Winegar, Deborah A., Sznaidman, Marcos L., Lambert, Millard H., Xu, H. Eric, Sternbach, Daniel D., Kliewer, Steven A., Hansen, Barbara C., Willson, Timothy M.

Volltext

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity von Sznaidman, Marcos L., Haffner, Curt D., Maloney, Patrick R., Fivush, Adam, Chao, Esther, Goreham, Donna, Sierra, Michael L., LeGrumelec, Christelle, Xu, H.Eric, Montana, Valerie G., Lambert, Millard H., Willson, Timothy M., Oliver, William R., Sternbach, Daniel D.

Volltext

Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I von Luzzio, Michael J, Besterman, Jeffrey M, Emerson, David L, Evans, Michael G, Lackey, Karen, Leitner, Peter L, McIntyre, Gordon, Morton, Bradley, Myers, Peter L, Peel, Michael, Sisco, Jay M, Sternbach, Daniel D, Tong, Wei-Qin, Truesdale, Ann, Uehling, David E, Vuong, Alan, Yates, Julie

Volltext

Sequence-Specific Targeting of Duplex DNA Using a Camptothecin-Triple Helix Forming Oligonucleotide Conjugate and Topoisomerase I von Matteucci, Mark, Lin, Kuei-Ying, Huang, Teresa, Wagner, Richard, Sternbach, Daniel D, Mehrotra, Mukund, Besterman, Jeffrey M

Volltext

Phenoxyacetic acids as PPARδ partial agonists: Synthesis, optimization, and in vivo efficacy von Evans, Karen A., Shearer, Barry G., Wisnoski, David D., Shi, Dongchuan, Sparks, Steven M., Sternbach, Daniel D., Winegar, Deborah A., Billin, Andrew N., Britt, Christy, Way, James M., Epperly, Andrea H., Leesnitzer, Lisa M., Merrihew, Raymond V., Xu, Robert X., Lambert, Millard H., Jin, Jian

Volltext

A short, enantioselective synthesis of the carbocyclic nucleoside carbovir von Peel, Michael R, Sternbach, Daniel D, Johnson, M. Ross

Volltext

Reactions of a Cyclic Rhodium Carbenoid with Aromatic Compounds and Vinyl Ethers von Pirrung, Michael C, Zhang, Jiancun, Lackey, Karen, Sternbach, Daniel D, Brown, Frank

Volltext

Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis von Liu, Kevin G, Lambert, Millard H, Leesnitzer, Lisa M, Oliver, William, Ott, Ronda J, Plunket, Kelli D, Stuart, Ludwig W, Brown, Peter J, Willson, Timothy M, Sternbach, Daniel D

Volltext

Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ von Liu, Kevin G, Smith, Jennifer S, Ayscue, Andrea H, Henke, Brad R, Lambert, Millard H, Leesnitzer, Lisa M, Plunket, Kelli D, Willson, Timothy M, Sternbach, Daniel D

Volltext

A novel deprotection/functionalisation sequence using 2,4-dinitrobenzenesulfonamide: Part 2 von Messeri, Tommaso, Sternbach, Daniel D., Tomkinson, Nicholas C.O.

Volltext

Synthesis and biological activity of l-tyrosine-based PPARγ agonists with reduced molecular weight von Liu, Kevin G., Lambert, Millard H., Ayscue, Andrea H., Henke, Brad R., Leesnitzer, Lisa M., Oliver, Jr, William R., Plunket, Kelli D., Xu, H.Eric, Sternbach, Daniel D., Willson, Timothy M.

Volltext

A novel deprotection/functionalisation sequence using 2,4-dinitrobenzenesulfonamide: Part 1 von Messeri, Tommaso, Sternbach, Daniel D., Tomkinson, Nicholas C.O.

Volltext

A Novel Method for the Generation of Nitrile Oxides on Solid Phase:  Application to the Synthesis of Substituted Benzopyranoisoxazoles von Chao, Esther Y, Minick, Douglas J, Sternbach, Daniel D, Shearer, Barry G, Collins, Jon L

Volltext

In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues von EMERSON, D. L, BESTERMAN, J. M, BROWN, H. R, EVANS, M. G, LEITNER, P. P, LUZZIO, M. J, SHAFFER, J. E, STERNBACH, D. D, UEHLING, D, VUONG, A

Volltext

Peptide Ligands of pp60c-src SH2 Domains:  A Thermodynamic and Structural Study von Charifson, Paul S, Shewchuk, Lisa M, Rocque, Warren, Hummel, Conrad W, Jordan, Steven R, Mohr, Christopher, Pacofsky, Gregory J, Peel, Michael R, Rodriguez, Marc, Sternbach, Daniel D, Consler, Thomas G

Volltext

Rigid Analogs of Camptothecin as DNA Topoisomerase I Inhibitors von Lackey, Karen, Besterman, Jeffrey M, Fletcher, Wade, Leitner, Peter, Morton, Bradley, Sternbach, Daniel D

Volltext

Water Soluble Inhibitors of Topoisomerase I:  Quaternary Salt Derivatives of Camptothecin von Lackey, Karen, Sternbach, Daniel D, Croom, Dallas K, Emerson, David L, Evans, Michael G, Leitner, Peter L, Luzzio, Michael J, McIntyre, Gordon, Vuong, Alain, Yates, Julie, Besterman, Jeffrey M

Volltext

Synthesis of polyquinanes. 3. The total synthesis of (.+-.)-hirsutene: the intramolecular Diels-Alder approach von Sternbach, Daniel D, Ensinger, Carol L

Volltext