Oncogenic ERBB3 Mutations in Human Cancers von Jaiswal, Bijay S., Kljavin, Noelyn M., Stawiski, Eric W., Chan, Emily, Parikh, Chaitali, Durinck, Steffen, Chaudhuri, Subhra, Pujara, Kanan, Guillory, Joseph, Edgar, Kyle A., Janakiraman, Vasantharajan, Scholz, Rolf-Peter, Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Yuan, Wenlin, Peters, Brock A., Kan, Zhengyan, Stinson, Jeremy, Mak, Michelle, Modrusan, Zora, Eigenbrot, Charles, Firestein, Ron, Stern, Howard M., Rajalingam, Krishnaraj, Schaefer, Gabriele, Merchant, Mark A., Sliwkowski, Mark X., de Sauvage, Frederic J., Seshagiri, Somasekar

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Diverse somatic mutation patterns and pathway alterations in human cancers von Li, Li, Waring, Paul, Stern, Howard M, Stokoe, David, Zheng, Jianbiao, Eberhard, David A, Chaudhuri, Subhra, Moorhead, Martin, Wang, Weiru, Yue, Peng, Modrusan, Zora, Pujara, Kanan, Faham, Malek, Davis, David P, Eigenbrot, Charles, Tomsho, Lynn P, Janakiraman, Vasantharajan, Stinson, Jeremy, Bourgon, Richard, Carlton, Victoria E. H, Jaiswal, Bijay S, Seshagiri, Somasekar, Kaminker, Joshua S, Schuster, Stephan C, Kan, Zhengyan, Peters, Brock A, Cordes, Shaun, Zhang, Zemin, de Sauvage, Frederic J, Bhatt, Deepali, Haverty, Peter M, Yuan, Wenlin

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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy von Lee-Hoeflich, Si Tuen, Crocker, Lisa, Yao, Evelyn, Pham, Thinh, Munroe, Xander, Hoeflich, Klaus P, Sliwkowski, Mark X, Stern, Howard M

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Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events von Liu, Jinfeng, Lee, William, Jiang, Zhaoshi, Chen, Zhongqiang, Jhunjhunwala, Suchit, Haverty, Peter M, Gnad, Florian, Guan, Yinghui, Gilbert, Houston N, Stinson, Jeremy, Klijn, Christiaan, Guillory, Joseph, Bhatt, Deepali, Vartanian, Steffan, Walter, Kimberly, Chan, Jocelyn, Holcomb, Thomas, Dijkgraaf, Peter, Johnson, Stephanie, Koeman, Julie, Minna, John D, Gazdar, Adi F, Stern, Howard M, Hoeflich, Klaus P, Wu, Thomas D, Settleman, Jeff, de Sauvage, Frederic J, Gentleman, Robert C, Neve, Richard M, Stokoe, David, Modrusan, Zora, Seshagiri, Somasekar, Shames, David S, Zhang, Zemin

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TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer von Stinson, Susanna, Lackner, Mark R, Adai, Alex T, Yu, Nancy, Kim, Hyo-Jin, O'Brien, Carol, Spoerke, Jill, Jhunjhunwala, Suchit, Boyd, Zachary, Januario, Thomas, Newman, Robert J, Yue, Peng, Bourgon, Richard, Modrusan, Zora, Stern, Howard M, Warming, Søren, de Sauvage, Frederic J, Amler, Lukas, Yeh, Ru-Fang, Dornan, David

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents von Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B, Tien, Janet Y, Prior, Wei W, van Dijk, Suzanne, Wu, Hong, Gray, Daniel C, Davis, David P, Stern, Howard M, Murray, Lesley J, Hoeflich, Klaus P, Klumperman, Judith, Friedman, Lori S, Lin, Kui

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The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients von Jiang, Zhaoshi, Jhunjhunwala, Suchit, Liu, Jinfeng, Haverty, Peter M, Kennemer, Michael I, Guan, Yinghui, Lee, William, Carnevali, Paolo, Stinson, Jeremy, Johnson, Stephanie, Diao, Jingyu, Yeung, Stacy, Jubb, Adrian, Ye, Weilan, Wu, Thomas D, Kapadia, Sharookh B, de Sauvage, Frederic J, Gentleman, Robert C, Stern, Howard M, Seshagiri, Somasekar, Pant, Krishna P, Modrusan, Zora, Ballinger, Dennis G, Zhang, Zemin

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Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers von Parikh, Chaitali, Janakiraman, Vasantharajan, Wu, Wen-I, Foo, Catherine K, Kljavin, Noelyn M, Chaudhuri, Subhra, Stawiski, Eric, Lee, Brian, Lin, Jie, Li, Hong, Lorenzo, Maria N, Yuan, Wenlin, Guillory, Joseph, Jackson, Marlena, Rondon, Jesus, Franke, Yvonne, Bowman, Krista K, Sagolla, Meredith, Stinson, Jeremy, Wu, Thomas D, Wu, Jiansheng, Stokoe, David, Stern, Howard M, Brandhuber, Barbara J, Lin, Kui, Skelton, Nicholas J, Seshagiri, Somasekar

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Cancer genetics and drug discovery in the zebrafish von Stern, Howard M, Zon, Leonard I

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Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer von Liu, Jinfeng, McCleland, Mark, Stawiski, Eric W., Gnad, Florian, Mayba, Oleg, Haverty, Peter M., Durinck, Steffen, Chen, Ying-Jiun, Klijn, Christiaan, Jhunjhunwala, Suchit, Lawrence, Michael, Liu, Hanbin, Wan, Yinan, Chopra, Vivek, Yaylaoglu, Murat B., Yuan, Wenlin, Ha, Connie, Gilbert, Houston N., Reeder, Jens, Pau, Gregoire, Stinson, Jeremy, Stern, Howard M., Manning, Gerard, Wu, Thomas D., Neve, Richard M., de Sauvage, Frederic J., Modrusan, Zora, Seshagiri, Somasekar, Firestein, Ron, Zhang, Zemin

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient von Lee, William, Jiang, Zhaoshi, Liu, Jinfeng, Haverty, Peter M., Guan, Yinghui, Stinson, Jeremy, Yue, Peng, Zhang, Yan, Pant, Krishna P., Bhatt, Deepali, Ha, Connie, Johnson, Stephanie, Kennemer, Michael I., Mohan, Sankar, Nazarenko, Igor, Watanabe, Colin, Sparks, Andrew B., Shames, David S., Gentleman, Robert, de Sauvage, Frederic J., Stern, Howard, Pandita, Ajay, Ballinger, Dennis G., Drmanac, Radoje, Modrusan, Zora, Seshagiri, Somasekar, Zhang, Zemin

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Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes von LEE, Genee Y, HAVERTY, Peter M, DAVIS, David, STOKOE, David, SETTLEMAN, Jeffrey, DE SAUVAGE, Frederic J, NEVE, Richard M, LI LI, KLJAVIN, Noelyn M, BOURGON, Richard, LEE, James, STERN, Howard, MODRUSAN, Zora, SESHAGIRI, Somasekar, ZEMIN ZHANG

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Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass von Solloway, Mark J., Madjidi, Azadeh, Gu, Chunyan, Eastham-Anderson, Jeff, Clarke, Holly J., Kljavin, Noelyn, Zavala-Solorio, Jose, Kates, Lance, Friedman, Brad, Brauer, Matt, Wang, Jianyong, Fiehn, Oliver, Kolumam, Ganesh, Stern, Howard, Lowe, John B., Peterson, Andrew S., Allan, Bernard B.

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Duvelisib, an oral dual PI3K‐δ,γ inhibitor, shows clinical and pharmacodynamic activity in chronic lymphocytic leukemia and small lymphocytic lymphoma in a phase 1 study von O'Brien, Susan, Patel, Manish, Kahl, Brad S., Horwitz, Steven M., Foss, Francine M., Porcu, Pierluigi, Jones, Jeffrey, Burger, Jan, Jain, Nitin, Allen, Kerstin, Faia, Kerrie, Douglas, Mark, Stern, Howard M., Sweeney, Jennifer, Kelly, Patrick, Kelly, Virginia, Flinn, Ian

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Randomized Phase II Study of Dulanermin in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Advanced Non–Small-Cell Lung Cancer von SORIA, Jean-Charles, MARK, Zsuzsanna, HEI, Yong-Jiang, ASHKENAZI, Avi, STERN, Howard, AMLER, Lukas, YANG PAN, BLACKHALL, Fiona, ZATLOUKAL, Petr, SZIMA, Barna, ALBERT, István, JUHASZ, Erzsébet, PUJOL, Jean-Louis, KOZIELSKI, Jerzy, BAKER, Nigel, SMETHURST, Dominic

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Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes von Hu, Xiaolan, Stern, Howard M, Ge, Lin, O'Brien, Carol, Haydu, Lauren, Honchell, Cynthia D, Haverty, Peter M, Peters, Brock A, Wu, Thomas D, Amler, Lukas C, Chant, John, Stokoe, David, Lackner, Mark R, Cavet, Guy

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Immunohistochemistry and fluorescence in situ hybridization assessment of HER2 in clinical trials of adjuvant therapy for breast cancer (NCCTG N9831, BCIRG 006, and BCIRG 005) von Perez, Edith A., Press, Michael F., Dueck, Amylou C., Jenkins, Robert B., Kim, Chungyeul, Chen, Beiyun, Villalobos, Ivonne, Paik, Soonmyung, Buyse, Marc, Wiktor, Anne E., Meyer, Reid, Finnigan, Melanie, Zujewski, JoAnne, Shing, Mona, Stern, Howard M., Lingle, Wilma L., Reinholz, Monica M., Slamon, Dennis J.

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PTEN Loss Is Associated with Worse Outcome in HER2-Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance von Stern, Howard M, Gardner, Humphrey, Burzykowski, Tomasz, Elatre, Wafaa, O'Brien, Carol, Lackner, Mark R, Pestano, Gary A, Santiago, Angela, Villalobos, Ivonne, Eiermann, Wolfgang, Pienkowski, Tadeusz, Martin, Miguel, Robert, Nicholas, Crown, John, Nuciforo, Paolo, Bee, Valerie, Mackey, John, Slamon, Dennis J, Press, Michael F

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Analysis of Fcγ Receptor IIIa and IIa Polymorphisms: Lack of Correlation with Outcome in Trastuzumab-Treated Breast Cancer Patients von HURVITZ, Sara A, BETTING, David J, DAMARAJU, Sambasivarao, SLIWKOWSKI, Mark X, ROBERT, Nicholas J, VALERO, Vicente, CROWN, John, FALKSON, Carla, BRUFSKY, Adam, PIENKOWSKI, Tadeusz, EIERMANN, Wolfgang, MARTIN, Miguel, STERN, Howard M, BEE, Valerie, MARATHE, Omkar, SLAMON, Dennis J, TIMMERMAN, John M, QUINAUX, Emmanuel, STINSON, Jeremy, SESHAGIRI, Somasekar, YING ZHAO, BUYSE, Marc, MACKEY, John, DRIGA, Adrian

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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer von Rudin, Charles M, Durinck, Steffen, Stawiski, Eric W, Poirier, John T, Modrusan, Zora, Shames, David S, Bergbower, Emily A, Guan, Yinghui, Shin, James, Guillory, Joseph, Rivers, Celina Sanchez, Foo, Catherine K, Bhatt, Deepali, Stinson, Jeremy, Gnad, Florian, Haverty, Peter M, Gentleman, Robert, Chaudhuri, Subhra, Janakiraman, Vasantharajan, Jaiswal, Bijay S, Parikh, Chaitali, Yuan, Wenlin, Zhang, Zemin, Koeppen, Hartmut, Wu, Thomas D, Stern, Howard M, Yauch, Robert L, Huffman, Kenneth E, Paskulin, Diego D, Illei, Peter B, Varella-Garcia, Marileila, Gazdar, Adi F, de Sauvage, Frederic J, Bourgon, Richard, Minna, John D, Brock, Malcolm V, Seshagiri, Somasekar

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