PHTHALAZINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM von BOSS HILDEGARD DR, TIMMERMAN HENDRIK DR, VAN DER MEY MARGARETHA, HATZELMANN ARMIN DR, KLEY HANS-PETER DR, BEUME ROLF DR, HAEFNER DIETRICH DR, STERK GEERT JAN S, VAN DER LAAN IVONNE JOHANNA

Volltext bestellen

Inhibition of autotransporter biogenesis by small molecules von Steenhuis, Maurice, Abdallah, Abdallah M., de Munnik, Sabrina M., Kuhne, Sebastiaan, Sterk, Geert‐Jan, van den Berg van Saparoea, Bart, Westerhausen, Sibel, Wagner, Samuel, van der Wel, Nicole N., Wijtmans, Maikel, van Ulsen, Peter, Jong, Wouter S. P., Luirink, Joen

Volltext

Identification of Phenylphthalazinones as a New Class of Leishmania infantum Inhibitors von Sijm, Maarten, Heuvel, Erik, Matheeussen, An, Caljon, Guy, Maes, Louis, Sterk, Geert‐Jan, Esch, Iwan J. P., Leurs, Rob

Volltext

Integrated Solutions for Combating Gully Erosion in Areas Prone to Soil Piping: Innovations from the Drylands of Northern Ethiopia von Frankl, Amaury, Deckers, Jozef, Moulaert, Lys, Van Damme, Alexander, Haile, Mitiku, Poesen, Jean, Nyssen, Jan

Volltext

Structural Optimization of BIPPO Analogs as Potent Antimalarials von Zheng, Yang, Matheeussen, An, Maes, Louis, Caljon, Guy, Sterk, Geert Jan, Leurs, Rob

Volltext

Surgery for Locally Advanced Pancreatic Cancer Following Induction Chemotherapy: A Single-Center Experience von Theijse, Rutger T., Stoop, Thomas F., Leenart, Philip D., Lutchman, Kishan R. D., Erdmann, Joris I., Daams, Freek, Zonderhuis, Babs M., Festen, Sebastiaan, Swijnenburg, Rutger-Jan, van Gulik, Thomas M., Schoorlemmer, Annuska, Sterk, André L. A., van Dieren, Susan, Fariña, Arantza, Voermans, Rogier P., Wilmink, Johanna W., Kazemier, Geert, Busch, Olivier R., Besselink, Marc G.

Volltext

The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target von Kunz, Stefan, Balmer, Vreni, Sterk, Geert Jan, Pollastri, Michael P, Leurs, Rob, Müller, Norbert, Hemphill, Andrew, Spycher, Cornelia

Volltext

Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor: A medicinal chemistry and QTAIM study von Zidar, Nace, Emanuel Cotman, Andrej, Sinnige, Wessel, Benek, Ondrej, Barančokova, Michaela, Zega, Anamarija, Peterlin Mašič, Lucija, Tomašič, Tihomir, Ilaš, Janez, Henderson, Sara R., Mundy, Julia E.A., Maxwell, Anthony, Stevenson, Clare E.M., Lawson, David M., Jan Sterk, Geert, Tosso, Rodrigo, Gutierrez, Lucas, Enriz, Ricardo D., Kikelj, Danijel

Volltext

Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds von Salado, Irene G, Singh, Abhimanyu K, Moreno-Cinos, Carlos, Sakaine, Guna, Siderius, Marco, Van der Veken, Pieter, Matheeussen, An, van der Meer, Tiffany, Sadek, Payman, Gul, Sheraz, Maes, Louis, Sterk, Geert-Jan, Leurs, Rob, Brown, David, Augustyns, Koen

Volltext

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages von Munday, Jane C, Kunz, Stefan, Kalejaiye, Titilola D, Siderius, Marco, Schroeder, Susanne, Paape, Daniel, Alghamdi, Ali H, Abbasi, Zainab, Huang, Sheng Xiang, Donachie, Anne-Marie, William, Samia, Sabra, Abdel Nasser, Sterk, Geert Jan, Botros, Sanaa S, Brown, David G, Hoffman, Charles S, Leurs, Rob, de Koning, Harry P

Volltext

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors von de Heuvel, Erik, Singh, Abhimanyu K., Edink, Ewald, van der Meer, Tiffany, van der Woude, Melanie, Sadek, Payman, Krell-Jørgensen, Mikkel P., van den Bergh, Toine, Veerman, Johan, Caljon, Guy, Kalejaiye, Titilola D., Wijtmans, Maikel, Maes, Louis, de Koning, Harry P., Jan Sterk, Geert, Siderius, Marco, de Esch, Iwan J.P., Brown, David G., Leurs, Rob

Volltext

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A? von Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K, Botros, Sanaa S, William, Samia, Sabra, Abdel-Nasser A, Maes, Louis, Caljon, Guy, Gil, Carmen, Martinez, Ana, Salado, Irene G, Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J P, van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob

Volltext

Lead Optimization of the 5‑Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy von Zheng, Yang, van den Kerkhof, Magali, Ibrahim, Mohamed, De Esch, Iwan J. P., Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob

Volltext

Evaluating in Situ Water and Soil Conservation Practices with a Fully Coupled, Surface/Subsurface Process-Based Hydrological Model in Tigray, Ethiopia von Opolot, Emmanuel, Araya, Tesfay, Nyssen, Jan, Al-Barri, Bashar, Verbist, Koen, Cornelis, Wim M.

Volltext

3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity von Zheng, Yang, Müller, Joachim, Kunz, Stefan, Siderius, Marco, Maes, Louis, Caljon, Guy, Müller, Norbert, Hemphill, Andrew, Sterk, Geert Jan, Leurs, Rob

Volltext

Discovery of 5‑Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy von Zheng, Yang, van den Kerkhof, Magali, van der Meer, Tiffany, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, de Esch, Iwan J. P., Siderius, Marco, Matheeussen, An, Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob

Volltext

Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets von de Koning, Harry P., Gould, Matthew K., Sterk, Geert Jan, Tenor, Hermann, Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas

Volltext

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa von Cotman, Andrej Emanuel, Durcik, Martina, Benedetto Tiz, Davide, Fulgheri, Federica, Secci, Daniela, Sterle, Maša, Možina, Štefan, Skok, Žiga, Zidar, Nace, Zega, Anamarija, Ilaš, Janez, Peterlin Mašič, Lucija, Tomašič, Tihomir, Hughes, Diarmaid, Huseby, Douglas L., Cao, Sha, Garoff, Linnéa, Berruga Fernández, Talía, Giachou, Paraskevi, Crone, Lisa, Simoff, Ivailo, Svensson, Richard, Birnir, Bryndis, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., de la Cruz, Mercedes, Glinghammar, Björn, Lenhammar, Lena, Henderson, Sara R., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel

Volltext

Structure Activity Relationship of N -Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes von Sijm, Maarten, Maes, Louis, de Esch, Iwan J P, Caljon, Guy, Sterk, Geert Jan, Leurs, Rob

Volltext

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling von Denecke, Shane, Malfara, Madeline F, Hodges, Kelly R, Holmes, Nikki A, Williams, Andre R, Gallagher-Teske, Julia H, Pascarella, Julia M, Daniels, Abigail M, Sterk, Geert Jan, Leurs, Rob, Ruthel, Gordon, Hoang, Rachel, Povelones, Megan L, Povelones, Michael

Volltext