Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers von Goodman, Aaron M, Kato, Shumei, Bazhenova, Lyudmila, Patel, Sandip P, Frampton, Garrett M, Miller, Vincent, Stephens, Philip J, Daniels, Gregory A, Kurzrock, Razelle

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ECD cotton effect approximated by the Gaussian curve and other methods von Stephens, Philip J., Harada, Nobuyuki

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Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study von Sicklick, Jason K., Kato, Shumei, Okamura, Ryosuke, Schwaederle, Maria, Hahn, Michael E., Williams, Casey B., De, Pradip, Krie, Amy, Piccioni, David E., Miller, Vincent A., Ross, Jeffrey S., Benson, Adam, Webster, Jennifer, Stephens, Philip J., Lee, J. Jack, Fanta, Paul T., Lippman, Scott M., Leyland-Jones, Brian, Kurzrock, Razelle

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Biliary cancer: Utility of next‐generation sequencing for clinical management von Javle, Milind, Bekaii‐Saab, Tanios, Jain, Apurva, Wang, Ying, Kelley, Robin Katie, Wang, Kai, Kang, Hyunseon C., Catenacci, Daniel, Ali, Siraj, Krishnan, Sunil, Ahn, Daniel, Bocobo, Andrea Grace, Zuo, Mingxin, Kaseb, Ahmed, Miller, Vincent, Stephens, Philip J., Meric‐Bernstam, Funda, Shroff, Rachna, Ross, Jeffrey

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Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC von Riess, Jonathan W., Gandara, David R., Frampton, Garrett M., Madison, Russell, Peled, Nir, Bufill, Jose A., Dy, Grace K., Ou, Sai-Hong Ignatius, Stephens, Philip J., McPherson, John D., Lara, Primo N., Burich, Rebekah A., Ross, Jeffrey S., Miller, Vincent A., Ali, Siraj M., Mack, Philip C., Schrock, Alexa B.

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Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer von Lin, Jessica J, Zhu, Viola W, Yoda, Satoshi, Yeap, Beow Y, Schrock, Alexa B, Dagogo-Jack, Ibiayi, Jessop, Nicholas A, Jiang, Ginger Y, Le, Long P, Gowen, Kyle, Stephens, Philip J, Ross, Jeffrey S, Ali, Siraj M, Miller, Vincent A, Johnson, Melissa L, Lovly, Christine M, Hata, Aaron N, Gainor, Justin F, Iafrate, Anthony J, Shaw, Alice T, Ou, Sai-Hong Ignatius

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Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion von Albacker, Lee A, Wu, Jeremy, Smith, Peter, Warmuth, Markus, Stephens, Philip J, Zhu, Ping, Yu, Lihua, Chmielecki, Juliann

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The distribution of BRAF gene fusions in solid tumors and response to targeted therapy von Ross, Jeffrey S., Wang, Kai, Chmielecki, Juliann, Gay, Laurie, Johnson, Adrienne, Chudnovsky, Jacob, Yelensky, Roman, Lipson, Doron, Ali, Siraj M, Elvin, Julia A., Vergilio, Jo‐Anne, Roels, Steven, Miller, Vincent A, Nakamura, Brooke N., Gray, Adam, Wong, Michael K, Stephens, Philip J

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Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3 von Ross, Jeffrey S., Fakih, Marwan, Ali, Siraj M., Elvin, Julia A., Schrock, Alexa B., Suh, James, Vergilio, Jo‐Anne, Ramkissoon, Shakti, Severson, Eric, Daniel, Sugganth, Fabrizio, David, Frampton, Garrett, Sun, James, Miller, Vincent A., Stephens, Philip J., Gay, Laurie M.

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Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions von Lovly, Christine M, Gupta, Abha, Lipson, Doron, Otto, Geoff, Brennan, Tina, Chung, Catherine T, Borinstein, Scott C, Ross, Jeffrey S, Stephens, Philip J, Miller, Vincent A, Coffin, Cheryl M

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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies von Lipson, Doron, Capelletti, Marzia, Yelensky, Roman, Otto, Geoff, Parker, Alex, Jarosz, Mirna, Curran, John A, Balasubramanian, Sohail, Bloom, Troy, Brennan, Kristina W, Donahue, Amy, Downing, Sean R, Frampton, Garrett M, Garcia, Lazaro, Juhn, Frank, Mitchell, Kathy C, White, Emily, White, Jared, Zwirko, Zac, Peretz, Tamar, Nechushtan, Hovav, Soussan-Gutman, Lior, Kim, Jhingook, Sasaki, Hidefumi, Kim, Hyeong Ryul, Park, Seung-il, Ercan, Dalia, Sheehan, Christine E, Ross, Jeffrey S, Cronin, Maureen T, Jänne, Pasi A, Stephens, Philip J

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Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High‐Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures von Johnson, Adrienne, Severson, Eric, Gay, Laurie, Vergilio, Jo‐Anne, Elvin, Julia, Suh, James, Daniel, Sugganth, Covert, Mandy, Frampton, Garrett M., Hsu, Sigmund, Lesser, Glenn J., Stogner‐Underwood, Kimberly, Mott, Ryan T., Rush, Sarah Z., Stanke, Jennifer J., Dahiya, Sonika, Sun, James, Reddy, Prasanth, Chalmers, Zachary R., Erlich, Rachel, Chudnovsky, Yakov, Fabrizio, David, Schrock, Alexa B., Ali, Siraj, Miller, Vincent, Stephens, Philip J., Ross, Jeffrey, Crawford, John R., Ramkissoon, Shakti H.

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ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer von Pietrantonio, Filippo, Di Nicolantonio, Federica, Schrock, Alexa B, Lee, Jeeyun, Tejpar, Sabine, Sartore-Bianchi, Andrea, Hechtman, Jaclyn F, Christiansen, Jason, Novara, Luca, Tebbutt, Niall, Fucà, Giovanni, Antoniotti, Carlotta, Kim, Seung Tae, Murphy, Danielle, Berenato, Rosa, Morano, Federica, Sun, James, Min, Bosun, Stephens, Philip J, Chen, Marissa, Lazzari, Luca, Miller, Vincent A, Shoemaker, Robert, Amatu, Alessio, Milione, Massimo, Ross, Jeffrey S, Siena, Salvatore, Bardelli, Alberto, Ali, Siraj M, Falcone, Alfredo, de Braud, Filippo, Cremolini, Chiara

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer von Iacobuzio-Donahue, Christine, Futreal, P. Andrew, Campbell, Peter J, Yachida, Shinichi, Mudie, Laura J, Stephens, Philip J, Pleasance, Erin D, Stebbings, Lucy A, Morsberger, Laura A, Latimer, Calli, McLaren, Stuart, Lin, Meng-Lay, McBride, David J, Varela, Ignacio, Nik-Zainal, Serena A, Leroy, Catherine, Jia, Mingming, Menzies, Andrew, Butler, Adam P, Teague, Jon W, Griffin, Constance A, Burton, John, Swerdlow, Harold, Quail, Michael A, Stratton, Michael R

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Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease von Yaeger, Rona, Shah, Manish A, Miller, Vincent A, Kelsen, Judith R, Wang, Kai, Heins, Zachary J, Ross, Jeffrey S, He, Yuting, Sanford, Eric, Yantiss, Rhonda K, Balasubramanian, Sohail, Stephens, Philip J, Schultz, Nikolaus, Oren, Moshe, Tang, Laura, Kelsen, David

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New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next‐Generation Sequencing von Ross, Jeffrey S., Wang, Kai, Gay, Laurie, Al‐Rohil, Rami, Rand, Janne V., Jones, David M., Lee, Hwa J., Sheehan, Christine E., Otto, Geoff A., Palmer, Gary, Yelensky, Roman, Lipson, Doron, Morosini, Deborah, Hawryluk, Matthew, Catenacci, Daniel V. T., Miller, Vincent A., Churi, Chaitanya, Ali, Siraj, Stephens, Philip J.

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Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors von Frampton, Garrett M, Ali, Siraj M, Rosenzweig, Mark, Chmielecki, Juliann, Lu, Xinyuan, Bauer, Todd M, Akimov, Mikhail, Bufill, Jose A, Lee, Carrie, Jentz, David, Hoover, Rick, Ou, Sai-Hong Ignatius, Salgia, Ravi, Brennan, Tim, Chalmers, Zachary R, Jaeger, Savina, Huang, Alan, Elvin, Julia A, Erlich, Rachel, Fichtenholtz, Alex, Gowen, Kyle A, Greenbowe, Joel, Johnson, Adrienne, Khaira, Depinder, McMahon, Caitlin, Sanford, Eric M, Roels, Steven, White, Jared, Greshock, Joel, Schlegel, Robert, Lipson, Doron, Yelensky, Roman, Morosini, Deborah, Ross, Jeffrey S, Collisson, Eric, Peters, Malte, Stephens, Philip J, Miller, Vincent A

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2 von Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva

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Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity von Beltran, Himisha, Yelensky, Roman, Frampton, Garrett M, Park, Kyung, Downing, Sean R, MacDonald, Theresa Y, Jarosz, Mirna, Lipson, Doron, Tagawa, Scott T, Nanus, David M, Stephens, Philip J, Mosquera, Juan Miguel, Cronin, Maureen T, Rubin, Mark A

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Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade von Johnson, Douglas B, Frampton, Garrett M, Rioth, Matthew J, Yusko, Erik, Xu, Yaomin, Guo, Xingyi, Ennis, Riley C, Fabrizio, David, Chalmers, Zachary R, Greenbowe, Joel, Ali, Siraj M, Balasubramanian, Sohail, Sun, James X, He, Yuting, Frederick, Dennie T, Puzanov, Igor, Balko, Justin M, Cates, Justin M, Ross, Jeffrey S, Sanders, Catherine, Robins, Harlan, Shyr, Yu, Miller, Vincent A, Stephens, Philip J, Sullivan, Ryan J, Sosman, Jeffrey A, Lovly, Christine M

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