Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket von Maryanoff, Bruce E., O’Neill, John C., McComsey, David F., Yabut, Stephen C., Luci, Diane K., Gibbs, Alan C., Connelly, Margery A.

Volltext

Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site von Maryanoff, Bruce E, O'Neill, John C, McComsey, David F, Yabut, Stephen C, Luci, Diane K, Jordan, Alfonzo D, Masucci, John A, Jones, William J, Abad, Marta C, Gibbs, Alan C, Petrounia, Ioanna

Volltext

Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone von Costanzo, Michael J, Yabut, Stephen C, Almond, Harold R, Andrade-Gordon, Patricia, Corcoran, Thomas W, de Garavilla, Lawrence, Kauffman, Jack A, Abraham, William M, Recacha, Rosario, Chattopadhyay, Debashish, Maryanoff, Bruce E

Volltext

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives von Costanzo, Michael J., Yabut, Stephen C., Zhang, Han-Cheng, White, Kimberley B., de Garavilla, Lawrence, Wang, Yuanping, Minor, Lisa K., Tounge, Brett A., Barnakov, Alexander N., Lewandowski, Frank, Milligan, Cynthia, Spurlino, John C., Abraham, William M., Boswell-Smith, Victoria, Page, Clive P., Maryanoff, Bruce E.

Volltext

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design von Costanzo, Michael J, Almond, Harold R, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W, Giardino, Edward C, Kauffman, Jack A, Lewis, Joan M, de Garavilla, Lawrence, Haertlein, Barbara J, Maryanoff, Bruce E

Volltext

Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308 von Hoekstra, William J, Maryanoff, Bruce E, Damiano, Bruce P, Andrade-Gordon, Patricia, Cohen, Judith H, Costanzo, Michael J, Haertlein, Barbara J, Hecker, Leonard R, Hulshizer, Becky L, Kauffman, Jack A, Keane, Patricia, McComsey, David F, Mitchell, John A, Scott, Lorraine, Shah, Rekha D, Yabut, Stephen C

Volltext

Correction to Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site von Maryanoff, Bruce E, O'Neill, John C, McComsey, David F, Yabut, Stephen C, Luci, Diane K, Jordan, Alfonzo D, Masucci, John A, Jones, William J, Abad, Marta C, Gibbs, Alan C, Petrounia, Ioanna

Volltext

Exploration of Potential Prodrugs of RWJ-445167, an Oxyguanidine-based Dual Inhibitor of Thrombin and Factor Xa von Maryanoff, Bruce E., McComsey, David F., Costanzo, Michael J., Yabut, Stephen C., Lu, Tianbao, Player, Mark R., Giardino, Edward C., Damiano, Bruce P.

Volltext

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design von Costanzo, Michael J, Almond, Harold R, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W, Giardino, Edward C, Kauffman, Jack A, Lewis, Joan M, de Garavilla, Lawrence, Haertlein, Barbara J, Maryanoff, Bruce E

Volltext

Potent Thrombin Inhibitors That Probe the S1‘ Subsite:  Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group von Costanzo, Michael J, Maryanoff, Bruce E, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A, Lewis, Joan M, Krishnan, Raman, Tulinsky, Alexander

Volltext

The Heck reaction with unprotected allylic amidines and guanidines von Lawson, Edward C, Kinney, William A, Luci, Diane K, Yabut, Stephen C, Wisnoski, David, Maryanoff, Bruce E

Volltext

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design von Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A., Lewis, Joan M., de Garavilla, Lawrence, Haertlein, Barbara J., Maryanoff, Bruce E.

Volltext

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design von Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A., Lewis, Joan M., de Garavilla, Lawrence, Haertlein, Barbara J., Maryanoff, Bruce E.

Volltext

Potent Thrombin Inhibitors That Probe the S 1 ‘ Subsite:  Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group von Costanzo, Michael J., Maryanoff, Bruce E., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A., Lewis, Joan M., Krishnan, Raman, Tulinsky, Alexander

Volltext

Research Article: Exploration of Potential Prodrugs of RWJ-445167, an Oxyguanidine-based Dual Inhibitor of Thrombin and Factor Xa von Maryanoff, Bruce E, McComsey, David F, Costanzo, Michael J, Yabut, Stephen C, Lu, Tianbao, Player, Mark R, Giardino, Edward C, Damiano, Bruce P

Volltext

Solid-phase synthesis via N-terminal attachment to the 2-chlorotrityl resin von Hoekstra, William J., Greco, Michael N., Yabut, Stephen C., Hulshizer, Becky L., Maryanoff, Bruce E.

Volltext

In-depth study of tripeptide-based α-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug designs von COSTANZO, Michael J, ALMOND, Harold R, LEWIS, Joan M, DE GARAVILLA, Lawrence, HAERTLEIN, Barbara J, MARYANOFF, Bruce E, HECKER, Leonard R, SCHOTT, Mary R, YABUT, Stephen C, ZHANG, Han-Cheng, ANDRADE-GORDON, Patricia, CORCORAN, Thomas W, GIARDINO, Edward C, KAUFFMAN, Jack A

Volltext

Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042 von Hoekstra, William J., Maryanoff, Bruce E., Andrade-Gordon, Patricia, Cohen, Judith H., Costanzo, Michael J., Damiano, Bruce P., Haertlein, Barbara J., Harris, Bruce D., Kauffman, Jack A., Keane, Patricia M., McComsey, David F., Villani, Frank J., Yabut, Stephen C.

Volltext

SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS von YABUT, STEPHEN, C, MARYANOFF, BRUCE, E, TOUNGE, BRETT, COSTANZO, MICHAEL, J, ZHANG, HANNG

Volltext bestellen

2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist von ZHANG HANNG, YE HONG, CHEN CAILIN, YABUT STEPHEN C, WHITE KIMBERLY, MARYANOFF BRUCE

Volltext bestellen