Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 von Ismail, Hanafy M., Barton, Victoria, Phanchana, Matthew, Charoensutthivarakul, Sitthivut, Wong, Michael H. L., Hemingway, Janet, Biagini, Giancarlo A., O’Neill, Paul M., Ward, Stephen A.

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The molecular mechanism of action of artemisinin--the debate continues von O'Neill, Paul M, Barton, Victoria E, Ward, Stephen A

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Antimalarial activity of primaquine operates via a two-step biochemical relay von Camarda, Grazia, Jirawatcharadech, Piyaporn, Priestley, Richard S., Saif, Ahmed, March, Sandra, Wong, Michael H. L., Leung, Suet, Miller, Alex B., Baker, David A., Alano, Pietro, Paine, Mark J. I., Bhatia, Sangeeta N., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

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Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis von TAYLOR, MARK J., HOERAUF, ACHIM, TOWNSON, SIMON, SLATKO, BARTON E., WARD, STEPHEN A.

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Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential von Antoine, Thomas, Fisher, Nicholas, Amewu, Richard, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

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Handbook of Global Media Ethics von Ward, Stephen J. A

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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 von Capper, Michael J, O'Neill, Paul M, Fisher, Nicholas, Strange, Richard W, Moss, Darren, Ward, Stephen A, Berry, Neil G, Lawrenson, Alexandre S, Hasnain, S Samar, Biagini, Giancarlo A, Antonyuk, Svetlana V

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M1 macrophage features in severe Plasmodium falciparum malaria patients with pulmonary oedema von Klinkhamhom, Aekkarin, Glaharn, Supattra, Srisook, Charit, Ampawong, Sumate, Krudsood, Srivicha, Ward, Stephen A., Viriyavejakul, Parnpen

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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides von Clare, Rachel H., Bardelle, Catherine, Harper, Paul, Hong, W. David, Börjesson, Ulf, Johnston, Kelly L., Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A. N., Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L., Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G., O’Neill, Paul M., Taylor, Mark J., Ward, Stephen A.

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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria von Biagini, Giancarlo A, Fisher, Nicholas, Shone, Alison E, Mubaraki, Murad A, Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A, Nixon, Gemma L, Chadwick, James, Hemingway, Janet, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H. M, Berry, Neil G, O’Neill, Paul M, Ward, Stephen A

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Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis von Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.

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Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration von Aljayyoussi, Ghaith, Jenkins, Victoria A., Sharma, Raman, Ardrey, Alison, Donnellan, Samantha, Ward, Stephen A., Biagini, Giancarlo A.

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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae von Hübner, Marc P, Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J, Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W, Marsh, Kennan, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A, Pfarr, Kenneth, Kempf, Dale J, Hoerauf, Achim

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Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins von O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A

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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity von von Geldern, Thomas W, Morton, Howard E, Clark, Rick F, Brown, Brian S, Johnston, Kelly L, Ford, Louise, Specht, Sabine, Carr, Robert A, Stolarik, Deanne F, Ma, Junli, Rieser, Matthew J, Struever, Dominique, Frohberger, Stefan J, Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D, Hübner, Marc P, Hoerauf, Achim, Taylor, Mark J, Ward, Stephen A, Marsh, Kennan, Kempf, Dale J

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Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc1 Catalytic Turnover and Protein Expression von Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley J., Johnson, David J., Lawrenson, Alexandre S., Ranson, Hilary, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

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Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) von Pidathala, Chandrakala, Amewu, Richard, Pacorel, Bénédicte, Nixon, Gemma L, Gibbons, Peter, Hong, W. David, Leung, Suet C, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M

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Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models von Sjoberg, Hanna T, Pionnier, Nicolas, Aljayyoussi, Ghaith, Metuge, Haelly M, Njouendou, Abdel J, Chunda, Valerine C, Fombad, Fanny F, Tayong, Dizzle B, Gandjui, Narcisse V T, Akumtoh, Desmond N, Chounna, Patrick W N, Ndzeshang, Bertrand L, Lachaud, Sophie, Tekle, Fetene, Quirynen, Ludo, Engelen, Marc, Baeten, Benny, Steven, Andrew, Ward, Stephen A, Taylor, Mark J, Wanji, Samuel, Turner, Joseph D

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In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis von Ehrens, Alexandra, Lunde, Christopher S, Jacobs, Robert T, Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J, Lenz, Franziska, Fendler, Martina, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J, Freund, Yvonne R, Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J, Hoerauf, Achim, Hübner, Marc P

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Recent highlights in antimalarial drug resistance and chemotherapy research von Fidock, David A, Eastman, Richard T, Ward, Stephen A, Meshnick, Steven R

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