An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer von Soucy, Teresa A., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Gavin, James M., Adhikari, Sharmila, Brownell, James E., Burke, Kristine E., Cardin, David P., Critchley, Stephen, Cullis, Courtney A., Doucette, Amanda, Garnsey, James J., Gaulin, Jeffrey L., Gershman, Rachel E., Lublinsky, Anna R., McDonald, Alice, Mizutani, Hirotake, Narayanan, Usha, Olhava, Edward J., Peluso, Stephane, Rezaei, Mansoureh, Sintchak, Michael D., Talreja, Tina, Thomas, Michael P., Traore, Tary, Vyskocil, Stepan, Weatherhead, Gabriel S., Yu, Jie, Zhang, Julie, Dick, Lawrence R., Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Langston, Steven P.

Volltext

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ von Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.

Volltext

Structural Revision and Total Synthesis of Azaspiracid-1, Part 2: Definition of the ABCD Domain and Total Synthesis von Nicolaou, K. C., Koftis, Theocharis V., Vyskocil, Stepan, Petrovic, Goran, Ling, Taotao, Yamada, Yoichi M. A., Tang, Wenjun, Frederick, Michael O.

Volltext

Total Synthesis and Structural Elucidation of Azaspiracid-1. Final Assignment and Total Synthesis of the Correct Structure of Azaspiracid-1 von Nicolaou, K. C, Koftis, Theocharis V, Vyskocil, Stepan, Petrovic, Goran, Tang, Wenjun, Frederick, Michael O, Chen, David Y.-K, Li, Yiwei, Ling, Taotao, Yamada, Yoichi M. A

Volltext

Structural Revision and Total Synthesis of Azaspiracid-1, Part 1: Intelligence Gathering and Tentative Proposal von Nicolaou, K. C., Vyskocil, Stepan, Koftis, Theocharis V., Yamada, Yoichi M. A., Ling, Taotao, Chen, David Y.-K., Tang, Wenjun, Petrovic, Goran, Frederick, Michael O., Li, Yiwei, Satake, Masayuki

Volltext

Total Synthesis of the Proposed Azaspiracid-1 Structure, Part 1: Construction of the Enantiomerically Pure C1-C20, C21-C27, and C28-C40 Fragments von Nicolaou, K. C., Li, Yiwei, Uesaka, Noriaki, Koftis, Theocharis V., Vyskocil, Stepan, Ling, Taotao, Govindasamy, Mugesh, Qian, Wenyuan, Bernal, Federico, Chen, David Y.-K.

Volltext

Synthesis of enantiomerically pure binaphthyl derivatives. Mechanism of the enantioselective, oxidative coupling of naphthols and designing a catalytic cycle von Smrcina, Martin, Polakova, Jana, Vyskocil, Stepan, Kocovsky, Pavel

Volltext

Non-Symmetrically Substituted 1,1‘-Binaphthyls in Enantioselective Catalysis von Kocovsky, Pavel, Vyskocil, Stepan, Smrcina, Martin

Volltext

Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route von Vyskocil, Stepan, Cardin, David, Ciavarri, Jeffrey, Conlon, Joe, Cullis, Courtney, England, Dylan, Gershman, Rachel, Gigstad, Kenneth, Gipson, Krista, Gould, Alexandra, Greenspan, Paul, Griffin, Robert, Gulavita, Nanda, Harrison, Sean, Hu, Zhigen, Hu, Yongbo, Hata, Akito, Huang, Jian, Huang, Shih-Chung, Janowick, Dave, Jones, Matthew, Kolev, Vihren, Langston, Steven P, Lee, Hong Myung, Li, Gang, Lok, David, Ma, Liting, Mai, Doanh, Malley, Jenna, Matsuda, Atsushi, Mizutani, Hirotake, Mizutani, Miho, Molchanova, Nina, Nunes, Elise, Pusalkar, Sandeep, Renou, Christelle, Rowland, Scott, Sato, Yosuke, Shaw, Michael, Shen, Luhua, Shi, Zhan, Skene, Robert, Soucy, Francois, Stroud, Steve, Xu, He, Xu, Tianlin, Abu-Yousif, Adnan O, Zhang, Ji

Volltext

Selective Cross-Coupling of 2-Naphthol and 2-Naphthylamine Derivatives. A Facile Synthesis of 2,2',3-Trisubstituted and 2,2',3,3'-Tetrasubstituted 1,1'-Binaphthyls von Smrcina, Martin, Vyskocil, Stepan, Maca, Bohumil, Polasek, Miroslav, Claxton, Thomas A, Abbott, Andrew P, Kocovsky, Pavel

Volltext

Synthesis of 3-Hexahelicenol and Its Transformation to 3-Hexahelicenylamines, Diphenylphosphine, Methyl Carboxylate, and Dimethylthiocarbamate von Teplý, Filip, Stará, Irena G, Starý, Ivo, Kollárovič, Adrian, Šaman, David, Vyskočil, Štěpán, Fiedler, Pavel

Volltext

2,8′-Disubstituted-1,1′-Binaphthyls: A New Pattern in Chiral Ligands von Vyskočil, Štěpán, Meca, Luděk, Tišlerová, Iva, Císařová, Ivana, Polášek, Miroslav, Harutyunyan, Syuzanna R., Belokon, Yuri N., Stead, Russel M. J., Farrugia, Louis, Lockhart, Stephen C., Mitchell, William L., Kočovský, Pavel

Volltext

Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors von Gould, Alexandra E, Adams, Ruth, Adhikari, Sharmila, Aertgeerts, Kathleen, Afroze, Roushan, Blackburn, Christopher, Calderwood, Emily F, Chau, Ryan, Chouitar, Jouhara, Duffey, Matthew O, England, Dylan B, Farrer, Cheryl, Forsyth, Nancy, Garcia, Khristofer, Gaulin, Jeffery, Greenspan, Paul D, Guo, Ribo, Harrison, Sean J, Huang, Shih-Chung, Iartchouk, Natalia, Janowick, Dave, Kim, Mi-Sook, Kulkarni, Bheemashankar, Langston, Steven P, Liu, Jane X, Ma, Li-Ting, Menon, Saurabh, Mizutani, Hirotake, Paske, Erin, Renou, Christelle C, Rezaei, Mansoureh, Rowland, R. Scott, Sintchak, Michael D, Smith, Michael D, Stroud, Stephen G, Tregay, Ming, Tian, Yuan, Veiby, Ole P, Vos, Tricia J, Vyskocil, Stepan, Williams, Juliet, Xu, Tianlin, Yang, Johnny J, Yano, Jason, Zeng, Hongbo, Zhang, Dong Mei, Zhang, Qin, Galvin, Katherine M

Volltext

Total Synthesis of the Proposed Azaspiracid-1 Structure, Part 2: Coupling of the C1-C20, C21-C27, and C28-C40 Fragments and Completion of the Synthesis von Nicolaou, K. C., Chen, David Y.-K., Li, Yiwei, Qian, Wenyuan, Ling, Taotao, Vyskocil, Stepan, Koftis, Theocharis V., Govindasamy, Mugesh, Uesaka, Noriaki

Volltext

Total Synthesis and Structural Elucidation of Azaspiracid-1. Synthesis-Based Analysis of Originally Proposed Structures and Indication of Their Non-Identity to the Natural Product von Nicolaou, K. C, Chen, David Y.-K, Li, Yiwei, Uesaka, Noriaki, Petrovic, Goran, Koftis, Theocharis V, Bernal, Federico, Frederick, Michael O, Govindasamy, Mugesh, Ling, Taotao, Pihko, Petri M, Tang, Wenjun, Vyskocil, Stepan

Volltext

Weak intra- and intermolecular interactions in a binaphthol imine: an experimental charge-density study on (±)-8′-benzhydrylideneamino-1,1′-binaphthyl-2-ol von Farrugia, Louis J., Kočovský, Pavel, Senn, Hans Martin, Vyskočil, Štěpán

Volltext

Synthesis of α-Amino Acids via Asymmetric Phase Transfer-Catalyzed Alkylation of Achiral Nickel(II) Complexes of Glycine-Derived Schiff Bases von Belokon, Yuri N, Bespalova, Natalia B, Churkina, Tatiana D, Císařová, Ivana, Ezernitskaya, Marina G, Harutyunyan, Syuzanna R, Hrdina, Radim, Kagan, Henri B, Kočovský, Pavel, Kochetkov, Konstantin A, Larionov, Oleg V, Lyssenko, Konstantin A, North, Michael, Polášek, Miroslav, Peregudov, Alexander S, Prisyazhnyuk, Vladimir V, Vyskočil, Štěpán

Volltext

Structural Revision and Total Synthesis of Azaspiracid-1, Part 1: Intelligence Gathering and Tentative Proposal von Nicolaou, K. C., Vyskocil, Stepan, Koftis, Theocharis V., Yamada, Yoichi M. A., Ling, Taotao, Chen, David Y.-K., Tang, Wenjun, Petrovic, Goran, Frederick, Michael O., Li, Yiwei, Satake, Masayuki

Volltext

Structural Revision and Total Synthesis of Azaspiracid-1, Part 2: Definition of the ABCD Domain and Total Synthesis von Nicolaou, K. C., Koftis, Theocharis V., Vyskocil, Stepan, Petrovic, Goran, Ling, Taotao, Yamada, Yoichi M. A., Tang, Wenjun, Frederick, Michael O.

Volltext

Derivatives of 2-Amino-2‘-diphenylphosphino-1,1‘-binaphthyl (MAP) and Their Application in Asymmetric Palladium(0)-Catalyzed Allylic Substitution von Vyskočil, Štěpán, Smrčina, Martin, Hanuš, Vladimír, Polášek, Miroslav, Kočovský, Pavel

Volltext