Quantitative Proteomics of the Cancer Cell Line Encyclopedia von Nusinow, David P., Szpyt, John, Ghandi, Mahmoud, Rose, Christopher M., McDonald, E. Robert, Kalocsay, Marian, Jané-Valbuena, Judit, Gelfand, Ellen, Schweppe, Devin K., Jedrychowski, Mark, Golji, Javad, Porter, Dale A., Rejtar, Tomas, Wang, Y. Karen, Kryukov, Gregory V., Stegmeier, Frank, Erickson, Brian K., Garraway, Levi A., Sellers, William R., Gygi, Steven P.

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Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition von Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Krishnamurthy Radhakrishna, Viveksagar, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A

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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation von Stegmeier, Frank, Amon, Angelika

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding von Bhang, Hyo-eun C, Ruddy, David A, Krishnamurthy Radhakrishna, Viveksagar, Caushi, Justina X, Zhao, Rui, Hims, Matthew M, Singh, Angad P, Kao, Iris, Rakiec, Daniel, Shaw, Pamela, Balak, Marissa, Raza, Alina, Ackley, Elizabeth, Keen, Nicholas, Schlabach, Michael R, Palmer, Michael, Leary, Rebecca J, Chiang, Derek Y, Sellers, William R, Michor, Franziska, Cooke, Vesselina G, Korn, Joshua M, Stegmeier, Frank

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KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer von Krall, Elsa B, Wang, Belinda, Munoz, Diana M, Ilic, Nina, Raghavan, Srivatsan, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Aguirre, Andrew J, Kim, Jong Wook, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Doench, John G, Janne, Pasi A, Shaw, Alice T, McDonald Iii, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Hahn, William C

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers von Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

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An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide) von Korpal, Manav, Korn, Joshua M, Gao, Xueliang, Rakiec, Daniel P, Ruddy, David A, Doshi, Shivang, Yuan, Jing, Kovats, Steve G, Kim, Sunkyu, Cooke, Vesselina G, Monahan, John E, Stegmeier, Frank, Roberts, Thomas M, Sellers, William R, Zhou, Wenlai, Zhu, Ping

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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions von Munoz, Diana M, Cassiani, Pamela J, Li, Li, Billy, Eric, Korn, Joshua M, Jones, Michael D, Golji, Javad, Ruddy, David A, Yu, Kristine, McAllister, Gregory, DeWeck, Antoine, Abramowski, Dorothee, Wan, Jessica, Shirley, Matthew D, Neshat, Sarah Y, Rakiec, Daniel, de Beaumont, Rosalie, Weber, Odile, Kauffmann, Audrey, McDonald, 3rd, E Robert, Keen, Nicholas, Hofmann, Francesco, Sellers, William R, Schmelzle, Tobias, Stegmeier, Frank, Schlabach, Michael R

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PTEN-deficient cancers depend on PIK3CB von Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, deBeaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae, Lengauer, Christoph

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers von Wee, Susan, Jagani, Zainab, Xiang, Kay Xiaoqin, Loo, Alice, Dorsch, Marion, Yao, Yung-Mae, Sellers, William R, Lengauer, Christoph, Stegmeier, Frank

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Cdc14 and Condensin Control the Dissolution of Cohesin-Independent Chromosome Linkages at Repeated DNA von D'Amours, Damien, Stegmeier, Frank, Amon, Angelika

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MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells von Wang, Yubao, Lee, Young-Mi, Baitsch, Lukas, Huang, Alan, Xiang, Yi, Tong, Haoxuan, Lako, Ana, Von, Thanh, Choi, Christine, Lim, Elgene, Min, Junxia, Li, Li, Stegmeier, Frank, Schlegel, Robert, Eck, Michael J, Gray, Nathanael S, Mitchison, Timothy J, Zhao, Jean J

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A Lentiviral MicroRNA-Based System for Single-Copy Polymerase II-Regulated RNA Interference in Mammalian Cells von Stegmeier, Frank, Hu, Guang, Rickles, Richard J., Hannon, Gregory J., Elledge, Stephen J.

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia von Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

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Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer von Lantermann, Alexandra B, Chen, Dongshu, McCutcheon, Kaitlin, Hoffman, Greg, Frias, Elizabeth, Ruddy, David, Rakiec, Daniel, Korn, Joshua, McAllister, Gregory, Stegmeier, Frank, Meyer, Matthew J, Sharma, Sreenath V

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Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts von Kuiken, Hendrik J., Dhakal, Sabin, Selfors, Laura M., Friend, Chandler M., Zhang, Tian, Callari, Maurizio, Schackmann, Ron C. J., Gray, G. Kenneth, Crowdis, Jett, Bhang, Hyo-eun C., Baslan, Timour, Stegmeier, Frank, Gygi, Steven P., Caldas, Carlos, Brugge, Joan S.

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Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas von NAYLOR, Tara L, HUAPING TANG, YAO, Yung-Mae, WARMUTH, Markus, LENZ, Georg, STEGMEIER, Frank, RATSCH, Boris A, ENNS, Andreas, LOO, Alice, LIQING CHEN, LENZ, Peter, WATERS, Nigel J, SCHULER, Walter, DÖRKEN, Bernd

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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling von Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E

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Abstract B21: CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions von Munoz, Diana, Stegmeier, Frank P., Schlabach, Michael

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tumor suppressor CYLD regulates entry into mitosis von Stegmeier, Frank, Sowa, Mathew E, Nalepa, Grzegorz, Gygi, Steven P, Harper, J. Wade, Elledge, Stephen J

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