Targeting bromodomains: epigenetic readers of lysine acetylation von Filippakopoulos, Panagis, Knapp, Stefan

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The bromodomain interaction module von Filippakopoulos, Panagis, Knapp, Stefan

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The ins and outs of selective kinase inhibitor development von Müller, Susanne, Chaikuad, Apirat, Gray, Nathanael S, Knapp, Stefan

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Bromodomains as therapeutic targets von Muller, Susanne, Filippakopoulos, Panagis, Knapp, Stefan

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Accurate calculation of the absolute free energy of binding for drug molecules von Aldeghi, Matteo, Heifetz, Alexander, Bodkin, Michael J, Knapp, Stefan, Biggin, Philip C

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Statistical Analysis on the Performance of Molecular Mechanics Poisson–Boltzmann Surface Area versus Absolute Binding Free Energy Calculations: Bromodomains as a Case Study von Aldeghi, Matteo, Bodkin, Michael J, Knapp, Stefan, Biggin, Philip C

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Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites von Vidler, Lewis R, Brown, Nathan, Knapp, Stefan, Hoelder, Swen

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Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery? von Zhao, Zheng, Wu, Hong, Wang, Li, Liu, Yi, Knapp, Stefan, Liu, Qingsong, Gray, Nathanael S

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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family von Filippakopoulos, Panagis, Picaud, Sarah, Mangos, Maria, Keates, Tracy, Lambert, Jean-Philippe, Barsyte-Lovejoy, Dalia, Felletar, Ildiko, Volkmer, Rudolf, Müller, Susanne, Pawson, Tony, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Knapp, Stefan

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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain von Picaud, Sarah, Wells, Christopher, Felletar, Ildiko, Brotherton, Deborah, Martin, Sarah, Savitsky, Pavel, Diez-Dacal, Beatriz, Philpott, Martin, Bountra, Chas, Lingard, Hannah, Fedorov, Oleg, Müller, Susanne, Brennan, Paul E., Knapp, Stefan, Filippakopoulos, Panagis

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The Structural Basis of PI3K Cancer Mutations: From Mechanism to Therapy von SHUJUAN LIU, KNAPP, Stefan, AHMED ASHOUR AHMED

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Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours von Krämer, Andreas, Knapp, Stefan

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Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma von ZHIXIANG CHENG, YUANYING GONG, YUFANG MA, KAIHUA LU, XIANG LU, PIERCE, Larry A, THOMPSON, Reid C, MULLER, Susanne, KNAPP, Stefan, JIALIANG WANG

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Development of a potent and selective chemical probe for the pleiotropic kinase CK2 von Wells, Carrow I., Drewry, David H., Pickett, Julie E., Tjaden, Amelie, Krämer, Andreas, Müller, Susanne, Gyenis, Laszlo, Menyhart, Daniel, Litchfield, David W., Knapp, Stefan, Axtman, Alison D.

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Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor von Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers von BRAULT, Laurent, GASSER, Christelle, BRACHER, Franz, HUBER, Kilian, KNAPP, Stefan, SCHWALLER, Jürg

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Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry von Fedorov, Oleg, Niesen, Frank H., Knapp, Stefan

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Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement von Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Hartnett, James R., Ingold, Morgan R., Zimmerman, Kristopher, Machleidt, Thomas, Kirkland, Thomas A., Huwiler, Kristin G., Ohana, Rachel Friedman, Slater, Michael, Otto, Paul, Cong, Mei, Wells, Carrow I., Berger, Benedict-Tilman, Hanke, Thomas, Glas, Carina, Ding, Ke, Drewry, David H., Huber, Kilian V.M., Willson, Timothy M., Knapp, Stefan, Müller, Susanne, Meisenheimer, Poncho L., Fan, Frank, Wood, Keith V., Robers, Matthew B.

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CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses von Hammitzsch, Ariane, Tallant, Cynthia, Fedorov, Oleg, O’Mahony, Alison, Brennan, Paul E., Hay, Duncan A., Martinez, Fernando O., Al-Mossawi, M. Hussein, de Wit, Jelle, Vecellio, Matteo, Wells, Christopher, Wordsworth, Paul, Müller, Susanne, Knapp, Stefan, Bowness, Paul

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A chemical toolbox for the study of bromodomains and epigenetic signaling von Wu, Qin, Heidenreich, David, Zhou, Stanley, Ackloo, Suzanne, Krämer, Andreas, Nakka, Kiran, Lima-Fernandes, Evelyne, Deblois, Genevieve, Duan, Shili, Vellanki, Ravi N., Li, Fengling, Vedadi, Masoud, Dilworth, Jeffrey, Lupien, Mathieu, Brennan, Paul E., Arrowsmith, Cheryl H., Müller, Susanne, Fedorov, Oleg, Filippakopoulos, Panagis, Knapp, Stefan

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